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Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

See all River Cruises that visit Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Azuero Peninsula : Balboa : Barro Colorado Island : Bocas del Toro : Cebaco Island : Chiriqui Lagoon : Coiba Island : Colon : Cristobal : Darien : Flamenco Island : Fort San Lorenzo : Fuerte Amador : Gatun : Gulf of Panama : Guna Yala : Isla Iguana : Lemon Cay : Pacheca Island : Panama Canal : Panama City : Parida Island : Pearl Islands : Playa Muerto : Portobelo : Punta Patino : San Blas Islands : San Jose Island

Panama
Cruise Specials

Oceania Cruises, Oceania Marina
Oceania Marina10 Night - Panama & Pristine Isles
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Falmouth, George Town, Miami
2027 Sails: Mar 15, More...
MSC Cruises, MSC Magnifica
MSC Magnifica53 Night - Msc World Cruise
Starting in Sydney AU, Australia, Noumea, New Caledonia, Luganville, Vanuatu, Apia, Western Samoa, Pago Pago, American Samoa, Honolulu, Hawaii, Hilo, Hawaii, Los Angeles, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Balboa, Panama, Cruising Panama Canal, La Romana, Dominican Republic, Road Town (Tortola), British Virgin Islands, Philipsburg, St Maarten, Las Palmas de Gran Canaria (Canary Islands), Spain, Ibiza (Balearic Islands), Spain, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2027 Sails: Mar 16, More...
MSC Cruises, MSC Magnifica
MSC Magnifica50 Night - Msc World Cruise
Starting in Sydney AU, Australia, Noumea, New Caledonia, Luganville, Vanuatu, Apia, Western Samoa, Pago Pago, American Samoa, Honolulu, Hawaii, Hilo, Hawaii, Los Angeles, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Balboa, Panama, Cruising Panama Canal, La Romana, Dominican Republic, Road Town (Tortola), British Virgin Islands, Philipsburg, St Maarten, Las Palmas de Gran Canaria (Canary Islands), Spain, Ibiza (Balearic Islands), Spain, Naples (Pompeii), Italy, Civitavecchia (Rome), Italy
2027 Sails: Mar 16, More...
Azamara Cruises, Azamara Journey
Azamara Journey11 Night - Peru & Central America : Lima, Panama City & Puerto Limon
Starting in Callao (Lima), Panama City (Fuerte Amador), Panama Canal (Cruising), Puerto Limon, Isla San Andres, Cozumel, Mexico, Miami, Florida
2027 Sails: Mar 18, More...
Princess Cruises, Island Princess
Island Princess16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Ensenada, Mexico, Los Angeles, California
2027 Sails: Mar 18, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam21 Night - Panama Canal & Southern Caribbean : Abc Islands
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, Cabo Rojo, Dominican Republic, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2027 Sails: Mar 21, More...
Scenic Luxury, Scenic Eclipse II
Scenic Eclipse II13 Night - Ancient Kingdoms and Natural Treasures : Chile to Panama
Starting in Valparaiso, Chile, Pinguino de Humboldt National Reserve, At Sea / Paracas, Peru, Paracas, Peru, Salaverry, Peru, Manta, Ecuador, Utria National Park / Ensenada de Utria, Colombia, Darien National Park / Playa del Muerto, Panama, Panama City, Panama
2027 Sails: Mar 21, More...
Scenic Luxury, Scenic Eclipse II
Scenic Eclipse II24 Night - Ultimate South America to the Caribbean Through the Panama Canal
Starting in Valparaiso, Chile, Pinguino de Humboldt National Reserve, At Sea / Paracas, Peru, Paracas, Peru, Salaverry, Peru, Manta, Ecuador, Utria National Park / Ensenada de Utria, Colombia, Darien National Park / Playa del Muerto, Panama, Panama City, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Mar 21, More...
Viking Ocean, Viking Polaris
Viking Polaris17 Night - Panama & Scenic South America
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Cozumel, Mexico, Scenic Sailing Gulf of Mexico, Fort Lauderdale, Florida
2027 Sails: Mar 22, More...
Holland America, Oosterdam
Oosterdam16 Night - Inca & Panama Canal Discovery : Lima Overnight
Starting in San Antonio CL (Santiago), Chile, Coquimbo (La Serena), Chile, General San Martin (Pisco), Peru, Callao (Lima), Peru, Salaverry (Trujillo), Peru, Manta, Ecuador, Fuerte Amador, Panama, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2027 Sails: Mar 24, More...

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Panama Cruises