Panama Cruises

Cruises that visit Central America: Panama

Cruises that depart from Panama

Click on a cruise ship itinerary that visits Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Viking Ocean, Viking Mars

10 Night - Classic Panama Canal Passage
Starting in Fort Lauderdale, Florida, Sail the Caribbean Sea, Cozumel, Mexico, Belize City, Roatan, Sail the Caribbean Sea, Puerto Limon, Colon, Scenic Sailing Panama Canal, Panama City (Fuerte Amador)
2026 Sails: Nov 3, Dec 7, More...

Disney Cruise Line, Disney Magic

14 Night - Eastbound Panama Canal Cruise from San Diego Ending in Galveston
Starting in San Diego, Cabo San Lucas, Puerto Vallarta, Panama Canal, Cartagena ES, George Town, Grand Cayman, Galveston
2026 Sails: Nov 6, More...

Norwegian Cruise Line, Norwegian Sun

12 Night - Panama Canal - Miami
Starting in Miami, Fl, Great Stirrup Cay, Bahamas, Cabo Rojo, Dominican Republic, Oranjestad, Aruba, Willemstad AN, Netherlands Antilles, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, George Town, Cayman Islands, Miami, Fl
2026 Sails: Nov 6, More...

Princess Cruises, Sapphire Princess

16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Nov 6, More...

Viking Ocean, Viking Octantis

17 Night - Panama & Scenic South America
Starting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Nov 6, More...

Lindblad Expeditions, National Geographic Quest

7 Night - Panama and Colombia : Exploring the Caribbean Coast
Starting in Cartagena CO, Colombia / Embark Ship, Sanguare Natural Reserve / Cispata Bay, San Antero / Santa Cruz de Lorica / Tuchin, Capurgana and Sapzurro, Colombia, Guna Yala Archipelago, Portobelo, Gatun Lake, Panama City, Panama / Disembark Ship
2026 Sails: Nov 7, More...

PONANT, Le Bellot

7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Nov 7, More...

Holland America, Nieuw Amsterdam

21 Night - Panama Canal & Southern Caribbean Discovery
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Ocho Rios, Jamaica, Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Nov 8, More...

Holland America, Nieuw Amsterdam

12 Night - Panama Canal Discovery : Costa Rica & Greater Antilles
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Ocho Rios, Jamaica, Fort Lauderdale, Florida
2026 Sails: Nov 8, More...

Princess Cruises, Caribbean Princess

12 Night - Caribbean with Costa Rica & Panama Canal
Starting in Fort Lauderdale, Florida, Aruba, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Grand Cayman, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Nov 11, Dec 17, Dec 29, 2027: Feb 3, Feb 15, More...

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