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United States Cruise Departures

Cruises that depart from North America: United States

Cruises that visit United States

See all River Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alabama : Alaska : California : Florida : Hawaii : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Michigan : Minnesota : Missouri : New Jersey : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Texas : Virginia : Washington : Washington DC : Wisconsin : Wyoming

Departing from
United States
Cruise Specials

EXPLORA I8 Night - A Journey Through Mayan Marvels, Rich Reefs & Ocean Serenity
Starting in Miami, Merida (Progreso), Roatan Island, Belize City, Ocean Cay, Miami
2026 Sails: Nov 17, More...
Explora Journeys, EXPLORA I
EXPLORA I18 Night - An Extended Journey Through Caribbean Beauty & Ocean Stillness
Starting in Miami, Merida (Progreso), Roatan Island, Belize City, Ocean Cay, Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami
2026 Sails: Nov 17, More...
Viking River, Viking Mississippi
Viking Mississippi7 Night - Nashville, Memphis & the Cumberland
Starting in Nashville, Tennessee, Clarksville, Tennessee, Paducah, Kentucky, Cape Girardeau, Missouri, Scenic Sailing Upper Mississippi, Memphis, Tennessee
2026 Sails: Nov 17, More...
Celebrity Cruises, Celebrity Beyond
Celebrity Beyond4 Night - Western Caribbean Cruise
Starting in Fort Lauderdale, Florida, Cozumel, Mexico, Fort Lauderdale, Florida
2026 Sails: Nov 18, More...
Holland America, Oosterdam
Oosterdam31 Night - Panama Canal, Inca & South America : Chilean Fjords
Starting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, Valparaiso (Santiago), Chile, Puerto Montt, Chile, Puerto Chacabuco, Chile, Cruising Chilean Fjords, Pio XI Glacier (Bruggen Glacier), Chile, Scenic cruising Sarmiento Channel, Strait of Magellan, Punta Arenas, Chile, Cockburn Channel, Beagle Channel, Daylight cruising Glacier Alley, Ushuaia, Argentina, Scenic Cruising Cape Horn, Port Stanley, Falkland Islands, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 18, More...
Holland America, Oosterdam
Oosterdam16 Night - Inca & Panama Canal Discovery : Lima Overnight
Starting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, Valparaiso (Santiago), Chile
2026 Sails: Nov 18, More...
Norwegian Cruise Line, Norwegian Sun
Norwegian Sun11 Night - Panama Canal - Miami
Starting in Miami, Fl, Great Stirrup Cay, Bahamas, Cartagena CO, Panama Canal Gatun Lake, Panama, Colon, Panama, Puerto Limon, Costa Rica, Falmouth, Jamaica, George Town, Cayman Islands, Miami, Fl
2026 Sails: Nov 18, Nov 29, More...
Princess Cruises, Coral Princess
Coral Princess10 Night - Eastern Caribbean with St. Kitts
Starting in Fort Lauderdale, Florida, St Thomas, US Virgin Islands, St Kitts, Dominica, Antigua, St Maarten, Fort Lauderdale, Florida
2026 Sails: Nov 18, More...
Royal Caribbean, Explorer of the Seas
Explorer of the Seas9 Night - Southern Caribbean Cruise
Starting in Orlando (Port Canaveral), Fl, St Johns AG, Antigua, Bridgetown, Barbados, Roseau, Dominica, Basseterre, St Kitts and Nevis, Orlando (Port Canaveral), Fl
2026 Sails: Nov 18, More...
Silversea, Silver Shadow
Silver Shadow12 Night - Miami to Miami
Starting in Miami, Fl, San Juan, St John VI, Gustavia, St Barthelemy, St Johns, Little Bay, Montserrat, St Kitts (Basseterre), Jost Van Dyke, British Virgin Islands, Miami, Fl
2026 Sails: Nov 18, More...

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United States Cruise Departures