Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Windstar, Star Legend

8 Night - Spanish Mystery Cruise
Starting in Barcelona, Mystery Port, Malaga
2026 Sails: Nov 4, More...

Windstar, Star Legend

23 Night - Star Collector : Spanish Mystery & Atlantic Crossing
Starting in Barcelona, Mystery Port, Malaga, Tangier, Casablanca, Morocco, Funchal, Bridgetown
2026 Sails: Nov 4, More...

MSC Cruises, MSC Magnifica

8 Night - Mediterranean
Starting in Tarragona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Nov 5, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain
2026 Sails: Nov 5, More...

Oceania Cruises, Oceania Marina

10 Night - Radiant Rivieras
Starting in Barcelona, Alicante, Ibiza, Palma De Mallorca, Sete, Toulon, Saint-Tropez, Monte Carlo, Portofino, Florence / Pisa / Tuscany (Livorno), Rome (Civitavecchia)
2026 Sails: Nov 5, More...

Costa Cruise Lines, Costa Fascinosa

10 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Gibraltar, Tangier, Casablanca, Cadice, Malaga, Marseille, Savona, Barcelona
2026 Sails: Nov 6, More...

MSC Cruises, MSC Sinfonia

8 Night - Mediterranean
Starting in Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain
2026 Sails: Nov 6, Nov 20, More...

MSC Cruises, MSC World Europa

6 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain
2026 Sails: Nov 6, More...

Azamara Cruises, Azamara Onward

10 Night - Spain Intensive Cruise : Valencia, Malaga & Seville
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Gibraltar, Seville, Lisbon
2026 Sails: Nov 7, More...

PONANT, Le Dumont-d'Urville

8 Night - Atlantic Odyssey from the Iberian Peninsula to the Canary Islands
Starting in Malaga, Tangier, Casablanca, Funchal, Madeira, Arrecife de Lanzarote, Canary Islands, Santa Cruz de La Palma, Las Palmas de Gran Canaria, Canary Islands
2026 Sails: Nov 7, More...

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