Madrid Cruise Departures
Cruises that depart from Europe: Spain: Madrid
Cruises that visit Madrid
See all River Cruises that depart from Madrid
13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Pinhao, El Dorado, Porto, Lisbon
2026 Sails: Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, Oct 7, More...
13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Jun 21, Aug 23, More...27 Night - Highlights of Spain - Tour 2C
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Jun 21, More...20 Night - Highlights of Spain - Tour 2B
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jun 21, More...
12 Night - Yachtsman's Mediterranean Rivieras & Madrid Cruise Tour
Starting in Madrid, Spain, Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome
2026 Sails: Sep 7, More...13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Sep 13, More...
10 Night - Madrid & Secrets of the Douro
Starting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto
2026 Sails: Sep 23, More...13 Night - Madrid to Lisbon & Secrets of the Douro
Starting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto, Porto / Lisbon, Lisbon
2026 Sails: Sep 23, More...13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Ibiza, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Oct 4, More...
14 Night - Taste of Bordeaux (Wine Cruise) with Madrid, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Madrid, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cussac-Fort-Medoc, Cadillac, Bordeaux, Paris
2026 Sails: Oct 25, Nov 1, More...
Cruises that depart from Europe: Spain: Madrid
Cruises that visit Madrid
See all River Cruises that depart from Madrid
Click on a cruise ship itinerary sailing from Madrid (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Madrid), please visit: Cruise Search or try our Virtual Cruise Advisor™.
13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-CruiseStarting in Madrid, Salamanca, Vega de Terron, Pinhao, El Dorado, Porto, Lisbon
2026 Sails: Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, Oct 7, More...
13 Night - Highlights of Spain - Tour 2AStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Jun 21, Aug 23, More...
27 Night - Highlights of Spain - Tour 2CStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Jun 21, More...
20 Night - Highlights of Spain - Tour 2BStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jun 21, More...
12 Night - Yachtsman's Mediterranean Rivieras & Madrid Cruise TourStarting in Madrid, Spain, Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Porto Ercole, Rome
2026 Sails: Sep 7, More...
13 Night - Highlights of Spain - Tour 2AStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Sep 13, More...
10 Night - Madrid & Secrets of the DouroStarting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto
2026 Sails: Sep 23, More...
13 Night - Madrid to Lisbon & Secrets of the DouroStarting in Madrid, Madrid / Porto, Porto / Pinhao, Pinhao / Vega de Terron, Vega de Terron / Salamanca, Pocinho / Regua, Regua, Porto, Porto / Lisbon, Lisbon
2026 Sails: Sep 23, More...
13 Night - Highlights of Spain - Tour 2AStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Ibiza, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Oct 4, More...
14 Night - Taste of Bordeaux (Wine Cruise) with Madrid, San Sebastian Pre-Cruise and Paris Post CruiseStarting in Madrid, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cussac-Fort-Medoc, Cadillac, Bordeaux, Paris
2026 Sails: Oct 25, Nov 1, More...
