Madrid Cruise Departures
Cruises that depart from Europe: Spain: Madrid
Cruises that visit Madrid
See all River Cruises that depart from Madrid
13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto, Lisbon
2025 Sails: Dec 17, 2026: Nov 18, Dec 16, 2027: Mar 24, Apr 7, May 5, May 19, Jun 2, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, Nov 17, Dec 1, Dec 15, More...
13 Night - Madrid & Southern Spain Winter Escapes Cruise Tour
Starting in Madrid, Spain, Barcelona, Valencia, Cartagena ES, Gibraltar, Malaga, Palma De Mallorca, Barcelona
2026 Sails: Feb 23, More...
27 Night - Highlights of Spain - Tour 2C
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Apr 19, More...20 Night - Highlights of Spain - Tour 2B
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Apr 19, More...13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Apr 19, More...
12 Night - Yachtsman's Mediterranean Rivieras & Madrid Cruise Tour
Starting in Madrid, Spain, Barcelona, Palamos, Port Vendres, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Apr 22, More...27 Night - Highlights of Spain - Tour 2C
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: May 10, Jul 12, More...20 Night - Highlights of Spain - Tour 2B
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: May 10, Jul 12, More...13 Night - Highlights of Spain - Tour 2A
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: May 10, Jul 12, More...27 Night - Highlights of Spain - Tour 2C
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: May 31, Jun 21, Aug 23, More...
Cruises that depart from Europe: Spain: Madrid
Cruises that visit Madrid
See all River Cruises that depart from Madrid
Click on a cruise ship itinerary sailing from Madrid (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Madrid), please visit: Cruise Search or try our Virtual Cruise Advisor™.
13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-CruiseStarting in Madrid, Salamanca, Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto, Lisbon
2025 Sails: Dec 17, 2026: Nov 18, Dec 16, 2027: Mar 24, Apr 7, May 5, May 19, Jun 2, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, Nov 17, Dec 1, Dec 15, More...
13 Night - Madrid & Southern Spain Winter Escapes Cruise TourStarting in Madrid, Spain, Barcelona, Valencia, Cartagena ES, Gibraltar, Malaga, Palma De Mallorca, Barcelona
2026 Sails: Feb 23, More...
27 Night - Highlights of Spain - Tour 2CStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Apr 19, More...
20 Night - Highlights of Spain - Tour 2BStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Apr 19, More...
13 Night - Highlights of Spain - Tour 2AStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, Santa Margherita, Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Apr 19, More...
12 Night - Yachtsman's Mediterranean Rivieras & Madrid Cruise TourStarting in Madrid, Spain, Barcelona, Palamos, Port Vendres, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Apr 22, More...
27 Night - Highlights of Spain - Tour 2CStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: May 10, Jul 12, More...
20 Night - Highlights of Spain - Tour 2BStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: May 10, Jul 12, More...
13 Night - Highlights of Spain - Tour 2AStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: May 10, Jul 12, More...
27 Night - Highlights of Spain - Tour 2CStarting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: May 31, Jun 21, Aug 23, More...
