Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Palma De Mallorca, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Nov 8, Nov 15, More...

MSC Cruises, MSC Sinfonia

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain
2026 Sails: Nov 8, Nov 22, More...

Silversea, Silver Ray

10 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Palma De Mallorca, Gibraltar, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: Nov 8, More...

AmaWaterways Tours, AmaKristina Tours

13 Night - Colors of Provence (Wine Cruise) with Barcelona Pre-Cruise and Paris Post-Cruise
Starting in Barcelona, Arles, Avignon, Vivigani, Tournon, Vienne, Paris
2026 Sails: Nov 9, More...

Costa Cruise Lines, Costa Smeralda

5 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Nov 9, More...

Costa Cruise Lines, Costa Smeralda

3 Night - Europe from Barcelona to Savona
Starting in Barcelona, Spain, Civitavecchia / Rome, Savona, Italy
2026 Sails: Nov 9, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean Roundtrip from Palma De Mallorca
Starting in Palma De Mallorca, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona, Palma De Mallorca
2026 Sails: Nov 9, Nov 16, More...

Celebrity Cruises, Celebrity Eclipse

14 Night - Spain & Bermuda Transatlantic
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Cartagena ES, Malaga, Spain, Gibraltar, United Kingdom, Royal Naval Dockyard, Bermuda, Fort Lauderdale, Florida
2026 Sails: Nov 10, More...

Costa Cruise Lines, Costa Diadema

13 Night - Transatlantic from Las Palmas
Starting in Las Palmas, Santa Cruz de Tenerife, St Vincent / Cape Verde / Mindelo, Maceio, Salvador Bahia, Rio De Janeiro, Santos
2026 Sails: Nov 10, More...

Costa Cruise Lines, Costa Diadema

12 Night - Transatlantic from Las Palmas
Starting in Las Palmas, Santa Cruz de Tenerife, St Vincent / Cape Verde / Mindelo, Maceio, Salvador Bahia, Rio De Janeiro
2026 Sails: Nov 10, More...

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