Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Ritz-Carlton, Evrima

4 Night - Barcelona / Rome (Civitavecchia)
Starting in Barcelona, Monte Carlo, Portofino, Rome (Civitavecchia)
2026 Sails: Sep 8, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia, Savona, Toulon / La Seyne-sur-Mer, Palma De Mallorca, Alicante
2026 Sails: Sep 9, More...

Emerald Cruises, Emerald Sakara

9 Night - Spanish Shores & Beyond
Starting in Barcelona, Spain, Port-Vendres, France, Saint-Tropez, France, Monte Carlo, Monaco, Calvi, France, Porto Cervo, Italy, Mahon, Menorca, Spain, Ibiza, Spain, Palma De Mallorca, Spain
2026 Sails: Sep 10, More...

MSC Cruises, MSC Musica

4 Night - Mediterranean
Starting in Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy
2026 Sails: Sep 10, More...

Holland America, Oosterdam

11 Night - Around Italy's Boot : Italy, Dalmatia & Venice
Starting in Barcelona, Spain, Marseille (Provence), France, Livorno (Florence / Pisa), Italy, Civitavecchia (Rome), Italy, Naples (Pompeii / Amalfi), Italy, Cruising Strait of Messina, Kerkira, (Corfu), Greece, Dubrovnik, Croatia, Kotor, Montenegro, Scenic cruising Bay of Kotor, Zadar, Croatia, Trieste (Venice), Italy
2026 Sails: Sep 12, More...

Viking Ocean, Viking Star

12 Night - Mediterranean Odyssey
Starting in Barcelona, Tarragona, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sail the Ionian Sea, Corfu (Kerkyra), Dubrovnik, Croatia, Split, Venice (Chioggia)
2026 Sails: Sep 12, More...

Azamara Cruises, Azamara Quest

11 Night - Best of the Mediterranean Cruise : Monte Carlo, Rome & Sorrento
Starting in Barcelona, Provence (Marseille), Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Sorrento, Catania, (Sicily), Crotone, Kotor, Koper, Venice (Fusina)
2026 Sails: Sep 13, More...

Azamara Cruises, Azamara Quest

31 Night - Mediterranean Cruise : Italy, Croatia & Greece
Starting in Barcelona, Provence (Marseille), Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Sorrento, Catania, (Sicily), Crotone, Kotor, Koper, Venice (Fusina), Zadar, Sibenik, Korcula, Dubrovnik, Croatia, Kotor, Corfu, Chania, Crete, Athens (Piraeus), Chios, Istanbul, Canakkale (Kepez), Thessaloniki, Volos, Syros, Patmos, Nafplio, Athens (Piraeus)
2026 Sails: Sep 13, More...

Princess Tours, Sun Princess Tours

27 Night - Highlights of Spain - Tour 2C
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Naples, Italy (for Capri and Pompeii), Barcelona, Spain
2026 Sails: Sep 13, More...

Princess Tours, Sun Princess Tours

20 Night - Highlights of Spain - Tour 2B
Starting in Madrid, Spain, Valencia, Spain, Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 13, More...

<= Back

More =>