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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Norwegian Cruise Line, Norwegian Epic
Norwegian Epic14 Night - Repo - Transatlantic
Starting in Barcelona, Spain, Cadiz / Seville, Spain, Santa Cruz de Tenerife, St Thomas, Vi, Great Stirrup Cay, Bahamas, Orlando Beaches / Port Canaveral, Fl
2026 Sails: Nov 1, More...
PONANT, Le Laperouse
Le Laperouse10 Night - Volcanic Landscapes from Canary Islands to Cape Verde
Starting in Las Palmas de Gran Canaria, Canary Islands, Puerto del Rosario, Canary Islands, Arrecife de Lanzarote, Canary Islands, Santa Cruz de Tenerife, San Sebastian de la Gomera, Canary Islands, Mindelo, Praia, Dakar
2026 Sails: Nov 1, More...
SeaDream Yacht Club, SeaDream I
SeaDream I13 Night - Cruise from Malaga to St Maarten (Philipsburg)
Starting in Malaga, Funchal, Madeira, Philipsburg
2026 Sails: Nov 1, More...
Silversea, Silver Dawn
Silver Dawn7 Night - Barcelona to Civitavecchia
Starting in Barcelona, Palma De Mallorca, Cagliari (Sardinia), Tunis (La Goulette), Trapani, Sicily, Naples, Civitavecchia (Rome)
2026 Sails: Nov 1, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Nov 2, More...
MSC Cruises, MSC Divina
MSC Divina14 Night - Msc Grand Voyages
Starting in Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 2, More...
MSC Cruises, MSC Divina
MSC Divina13 Night - Msc Grand Voyages
Starting in Tarragona, Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 2, More...
MSC Cruises, MSC Opera
MSC Opera17 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Tangier (Tetouan), Morocco, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, La Romana, Dominican Republic, Catalina Island, Dominican Republic, Bridgetown, Barbados
2026 Sails: Nov 2, More...
MSC Cruises, MSC Opera
MSC Opera14 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Tangier (Tetouan), Morocco, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, St Kitts and Nevis, La Romana, Dominican Republic
2026 Sails: Nov 2, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia47 Night - Footsteps of Columbus
Starting in Barcelona, Palma De Mallorca, Alicante, Cartagena ES, Malaga, Seville (Cadiz), Portimao, Lisbon, Arrecife (Lanzarote), Las Palmas De Gran Canaria, Santa Cruz de La Palma, San Juan, Nassau, Miami, Tortola, St Johns AG, Castries, Scarborough, Cruising the Amazon River, Santarem (Amazon River), Boca Da Valeria (Amazon River), Manaus (Amazon River), Parintins (Amazon River), Alter Do Chao (Amazon River), Cruising the Amazon River, Bridgetown, Roseau, Philipsburg, San Juan, Nassau, Miami
2026 Sails: Nov 2, More...

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Spain Cruise Departures