Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Windstar, Wind Spirit

7 Night - Masterpieces at Sea : Mediterranean Island Mosaic
Starting in Barcelona, Palma De Mallorca, Mahon, Calvi, Bastia, Portoferraio, Rome
2026 Sails: Aug 13, More...

Windstar, Wind Spirit

14 Night - Star Collector : Captivating Corsica & Sardinia
Starting in Barcelona, Palma De Mallorca, Mahon, Calvi, Bastia, Portoferraio, Rome, Bastia, Ajaccio, France, Bonifacio, France, Alghero, Italy, Golfo Aranci, Italy, Rome
2026 Sails: Aug 13, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Menorca, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Aug 14, More...

Ritz-Carlton, Ilma

7 Night - Barcelona / Monte Carlo
Starting in Barcelona, Ibiza, Balearic Islands, Palma de Mallorca, Mallorca, Balearic Islands, Mahon, Menorca, Balearic Islands, Alghero, Sardinia, Saint-Tropez, Cannes, Monte Carlo
2026 Sails: Aug 14, More...

Celebrity Cruises, Celebrity Equinox

10 Night - Greek Isles & Turkey Cruise
Starting in Barcelona, Spain, Sicily (Messina), Italy, Athens (Piraeus), Greece, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Olympia (Katakolon), Greece, Rome (Civitavecchia), Italy
2026 Sails: Aug 15, More...

Cunard Line, Queen Victoria

7 Night - Italy and Spain
Starting in Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Aug 17, More...

Cunard Line, Queen Victoria

21 Night - Italy, Spain and Adriatic
Starting in Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Palma De Mallorca, Spain, Barcelona, Spain
2026 Sails: Aug 17, More...

Cunard Line, Queen Victoria

14 Night - Italy, Spain and Adriatic
Starting in Barcelona, Spain, Ibiza, Spain, Cagliari, Sardinia, Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Aug 17, More...

Oceania Cruises, Oceania Sirena

Deal link -> Special

10 Night - Visions of Byzantium
Starting in Barcelona, Palermo (Sicily), Syracuse (Sicily), Argostoli (Cephalonia), Gythion, Paros, Athens (Piraeus), Ephesus (Kusadasi), Bozcaada (Troy), Istanbul
2026 Sails: Aug 17, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Alicante, Olbia, Civitavecchia, Savona, Toulon / La Seyne-sur-Mer, Palma De Mallorca
2026 Sails: Aug 18, More...

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