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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Lindblad Expeditions, National Geographic Quest
National Geographic Quest Cruises7 Night - Panama and Colombia : Exploring the Caribbean Coast
Starting in Panama City, Panama / Colon / Embark Ship, Portobelo, Guna Yala Archipelago, Capurgana and Sapzurro, Colombia, Santa Cruz de Lorica / San Antero / Tuchin, Cispata Bay / Sanguare Natural Reserve, Cartagena CO, Colombia / Disembark Ship
2027 Sails: Nov 12, More...
Viking Ocean, Viking Mars
Viking Mars Cruises10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Belize City, Cozumel, Mexico, Merida (Progreso), Sail the Caribbean Sea, Fort Lauderdale, Florida
2027 Sails: Nov 29, 2028: Jan 16, More...
Royal Caribbean International, Grandeur of the Seas
Grandeur of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Dec 4, Dec 11, Dec 25, 2028: Jan 29, Feb 5, Feb 12, Mar 11, Mar 25, Apr 22, More...
Crystal, Crystal Serenity
Crystal Serenity Cruise Ship11 Night - The Americas & Caribbean
Starting in Fuerte Amador (Panama City), Panama Canal Transit, Puerto Limon, Roatan Island, Santo Tomas, Belize City, Cozumel, Quintana Roo, Progreso (Merida), Fort Lauderdale
2027 Sails: Dec 11, More...
Royal Caribbean International, Grandeur of the Seas
Grandeur of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Dec 18, 2028: Jan 15, Feb 19, Apr 15, More...
Royal Caribbean International, Grandeur of the Seas
Grandeur of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2028 Sails: Jan 1, Jan 22, Feb 26, Mar 4, Apr 8, More...
Royal Caribbean International, Grandeur of the Seas
Grandeur of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2028 Sails: Jan 8, More...
Azamara, Azamara Quest
Azamara Quest Cruise Ship10 Night - Panama, Ecuadaor & Peru Cruise : Panama City, Manta & Lima (Callao)
Starting in Panama City (Fuerte Amador), Manta, Callao (Lima), Pisco, Coquimbo, Valparaiso
2028 Sails: Jan 14, More...
Oceania Cruises, Oceania Marina
Oceania Marina Cruise Ship10 Night - Classic Canal & Tropics
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2028 Sails: Jan 16, More...
Emerald Cruises, Emerald Azzurra
Emerald Azzurra Cruises7 Night - Coastal Adventures : Panama & Costa Rica
Starting in Panama City, Panama, Pearl Islands, Panama, Playa del Muerto / Darien National Park, Panama, Isla Cebaco, Panama, Golfito, Costa Rica, Quepos, Costa Rica, Curu and Isla Tortuga, Costa Rica, Puerto Caldera, Costa Rica
2028 Sails: Jan 24, More...

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Panama Cruise Departures