CruiseCompete: Easily Compare Multiple Offers from Cruise Experts
Compare offers from multiple travel agencies
1
Find your cruise
& request quotes
2
Compare members only prices,
upgrades, cabin credits & more!
3
Contact your preferred agent
for questions or to book your cruise
Over 1 million members
Panama City Cruise Departures

Cruises that depart from Central America: Panama: Panama City

Cruises that visit Panama City

Click on a cruise ship itinerary sailing from Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.


MS Roald Amundsen Cruises15 Night - Andean Coast - Expedition from Jungle to Desert (Itinerary 1) from Panama City to Valparaiso
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao / Lima, Peru; Paracas, Peru; Matarani, Peru; Arica, Chile; Valparaíso, Chile
2021 Sails: Oct 8, More...
MS Roald Amundsen Cruises11 Night - Panama, Ecuador and Peru - Incan Mysteries and Machu Picchu from Panama City to Lima
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao/Lima/Cusco/Sacred Valley; Sacred Valley/Machu Picchu/Sacred Valley; Sacred Valley/Cusco/Lima; Lima
2021 Sails: Oct 8, More...
MS Roald Amundsen Cruises13 Night - Panama, Ecuador and Peru - Incan Mysteries and Galapagos Islands from Panama City to Guayaquil
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao / Lima, Peru / Quito, Ecuador; Quito/Baltra Island/Santa Cruz Island; Santa Cruz Island/Baltra Island/Guayaquil
2021 Sails: Oct 8, More...
MS Fridtjof Nansen Cruises15 Night - Andean Coast - Expedition from Jungle to Desert (Itinerary 2) from Panama City to Valparaiso
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao / Lima, Peru; Paracas, Peru; Matarani, Peru; Arica, Chile; Valparaíso, Chile
2021 Sails: Oct 18, More...
MS Fridtjof Nansen Cruises11 Night - Panama, Ecuador and Peru - Incan Mysteries and Machu Picchu from Panama City to Lima
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao/Lima/Cusco/Sacred Valley; Sacred Valley/Machu Picchu/Sacred Valley; Sacred Valley/Cusco/Lima; Lima
2021 Sails: Oct 18, More...
MS Fridtjof Nansen Cruises13 Night - Panama, Ecuador and Peru - Incan Mysteries and Galapagos Islands from Panama City to Guayaquil
Starting in Panama City with stops in Manta, Ecuador; Puerto Bolivar (Machala), Ecuador; Guayaquil, Ecuador; Salaverry, Peru; Callao / Lima, Peru / Quito, Ecuador; Quito/Baltra Island/Santa Cruz Island; Santa Cruz Island/Baltra Island/Guayaquil
2021 Sails: Oct 18, More...
National Geographic Quest Cruises7 Night - Panama and Colombia: Exploring the Caribbean Coast Cruise from Panama City to Cartagena
Starting in Panama City, Panama/EMBARK; with stops in Gatún Lake; Portobelo; Guna Yala; Necoclí, Colombia; Santa Cruz del Islote; San Bernardo Archipelago; San Antero; Tuchín; Santa Cruz de Lorica; Cispatá Bay; Cartagena, Colombia/DISEMBARK
2021 Sails: Oct 30, Nov 13, 2022: Oct 22, Oct 29, Nov 5, Nov 12, More...
Viking Star Cruises10 Night - Classic Panama Canal Passage - Panama City (Fuerte Amador) to Ft. Lauderdale
Starting in Panama City (Fuerte Amador) with stops in Scenic Cruising: Panama Canal, Colon, Puerto Limon, Cruise the Caribbean Sea, Roatan, Belize City, Cozumel, Scenic Cruising: Gulf of Mexico, Key West, Ft. Lauderdale
2021 Sails: Nov 16, 2022: Nov 7, Dec 11, 2023: Feb 11, More...
Safari Voyager Cruises7 Night - Unveiled Wonders - Costa Rica & Panama Cruise from Panama City to San Jose
Starting in Panama City, Panama; with stops in Gulf of Panama | Marine Life Search; Granito de Oro, Coiba National Park; Golfo Dulce, Costa Rica; Osa Conservation Area; Curú National Wildlife Refuge; San José, Costa Rica
2021 Sails: Dec 3, Dec 17, Dec 31, 2022: Dec 3, Dec 17, Dec 31, More...
National Geographic Quest Cruises7 Night - Costa Rica and the Panama Canal Cruise from Panama City to San José
Starting in Panama City, Panama; with stops Colón/EMBARK; Gatun Lake; Panama Canal Transit; Gulf of Panama Islets; Isla Coiba National Park; Golfo Dulce; Osa Peninsula; Corcovado National Park; Puerto Caldera/DISEMBARK; San José, Costa Rica
2021 Sails: Dec 26, 2022: Jan 9, Jan 23, Feb 6, Feb 20, Dec 20, More...


Panama City Cruise Departures

Connecting cruisers with the best cruise prices on discount cruises since 2003. Privacy Policy

Cruise news from Cruise Compete, where you compare cruise prices to get the best cruise discounts and deals
Let our Virtual Cruise Advisor(TM) recommend the best cruises for you.