Panama City Cruise Departures
Cruises that depart from Central America: Panama: Panama City
Cruises that visit Panama City
10 Night - Canal & Coral Isles
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Puerto Limon, Roatan, Costa Maya, Mexico, Cozumel, Mexico, Miami
2026 Sails: Apr 24, More...
9 Night - Wellness Retreat - Panama City to Valparaiso
Starting in Panama City, Panama, Valparaiso, Chile
2026 Sails: Oct 26, More...
7 Night - Panama and Colombia : Exploring the Caribbean Coast
Starting in Panama City, Panama / Balboa / Embark Ship, Gatun Lake / Barro Colorado / Panama Canal Crossing, Portobelo, Guna Yala Archipelago, Capurgana and Sapzurro, Colombia, Santa Cruz de Lorica / San Antero / Tuchin, Cispata Bay / Sanguare Natural Reserve, Cartagena CO, Colombia / Disembark Ship
2026 Sails: Oct 31, More...
10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Nov 13, More...7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Colon / Embark Ship, Portobelo / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Pearl Islands, Playa Muerto, Darien National Park, Punta Patino Nature Reserve, Balboa / Disembark Ship / Panama City, Panama
2026 Sails: Dec 6, 2028: Mar 9, More...7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Balboa / Embark Ship, Punta Patino Nature Reserve, Playa Muerto, Darien National Park, Pearl Islands / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Portobelo, Colon / Disembark Ship / Panama City, Panama
2026 Sails: Dec 13, 2027: Jan 29, Nov 5, 2028: Jan 29, Mar 16, More...10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...7 Night - Costa Rica and the Panama Canal
Starting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2026 Sails: Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, More...
10 Night - Panama to Caribbean Joy
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Falmouth, George Town, Miami
2027 Sails: Jan 15, More...
28 Night - Canal to Coral Reefs
Starting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
Cruises that depart from Central America: Panama: Panama City
Cruises that visit Panama City
Click on a cruise ship itinerary sailing from Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
10 Night - Canal & Coral IslesStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Puerto Limon, Roatan, Costa Maya, Mexico, Cozumel, Mexico, Miami
2026 Sails: Apr 24, More...
9 Night - Wellness Retreat - Panama City to ValparaisoStarting in Panama City, Panama, Valparaiso, Chile
2026 Sails: Oct 26, More...
7 Night - Panama and Colombia : Exploring the Caribbean CoastStarting in Panama City, Panama / Balboa / Embark Ship, Gatun Lake / Barro Colorado / Panama Canal Crossing, Portobelo, Guna Yala Archipelago, Capurgana and Sapzurro, Colombia, Santa Cruz de Lorica / San Antero / Tuchin, Cispata Bay / Sanguare Natural Reserve, Cartagena CO, Colombia / Disembark Ship
2026 Sails: Oct 31, More...
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Nov 13, More...
7 Night - The Panama Canal, Pearl Islands and Darien JungleStarting in Panama City, Panama / Colon / Embark Ship, Portobelo / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Pearl Islands, Playa Muerto, Darien National Park, Punta Patino Nature Reserve, Balboa / Disembark Ship / Panama City, Panama
2026 Sails: Dec 6, 2028: Mar 9, More...
7 Night - The Panama Canal, Pearl Islands and Darien JungleStarting in Panama City, Panama / Balboa / Embark Ship, Punta Patino Nature Reserve, Playa Muerto, Darien National Park, Pearl Islands / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Portobelo, Colon / Disembark Ship / Panama City, Panama
2026 Sails: Dec 13, 2027: Jan 29, Nov 5, 2028: Jan 29, Mar 16, More...
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
7 Night - Costa Rica and the Panama CanalStarting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2026 Sails: Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, More...
10 Night - Panama to Caribbean JoyStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Falmouth, George Town, Miami
2027 Sails: Jan 15, More...
28 Night - Canal to Coral ReefsStarting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
