Colon Cruise Departures
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Sep 26, Oct 10, Nov 7, 2027: Jan 2, Jan 9, Feb 6, Feb 20, Feb 27, Mar 6, Mar 20, Apr 3, Apr 17, More...
10 Night - From Panama's Wild Beauty to Peruvian Shores
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Salaverry, Callao
2026 Sails: Oct 20, More...
7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Nov 7, More...10 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, 2027: Jan 14, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...10 Night - Secrets of Central America
Starting in Colon, Portobelo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Puerto Jimenez, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Santa Marta, Colombia, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Dec 19, 2027: Jan 30, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2027 Sails: Jan 5, Jan 19, Feb 2, More...
Cruises that depart from Central America: Panama: Colon
Cruises that visit Colon
Click on a cruise ship itinerary sailing from Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Sep 26, Oct 10, Nov 7, 2027: Jan 2, Jan 9, Feb 6, Feb 20, Feb 27, Mar 6, Mar 20, Apr 3, Apr 17, More...
10 Night - From Panama's Wild Beauty to Peruvian ShoresStarting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Salaverry, Callao
2026 Sails: Oct 20, More...
7 Night - Central America Jewels & Panama CanalStarting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Nov 7, More...
10 Night - Southern Caribbean CruiseStarting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, 2027: Jan 14, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
10 Night - Secrets of Central AmericaStarting in Colon, Portobelo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Puerto Jimenez, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Santa Marta, Colombia, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Dec 19, 2027: Jan 30, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2027 Sails: Jan 5, Jan 19, Feb 2, More...
