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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Windstar, Star Pride
Star Pride7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Dec 6, Dec 20, 2028: Jan 3, Jan 17, Jan 31, Feb 14, More...
Windstar Tours, Star Pride Tours
Star Pride Tours10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2027 Sails: Dec 6, 2028: Jan 3, Jan 17, Jan 31, Feb 14, More...
Crystal Cruises, Crystal Serenity
Crystal Serenity11 Night - The Americas & Caribbean
Starting in Fuerte Amador (Panama City), Panama Canal Transit, Puerto Limon, Roatan Island, Santo Tomas, Belize City, Cozumel, Quintana Roo, Progreso (Merida), Fort Lauderdale
2027 Sails: Dec 11, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Dec 18, 2028: Jan 15, Feb 19, Apr 15, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit9 Night - Cruise from Balboa to Puntarenas
Starting in Balboa (Panama City), Pearl Islands, Golfito, Puerto Jimenez, Quepos, Playa Panama, Puntarenas
2027 Sails: Dec 27, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2028 Sails: Jan 1, Jan 22, Feb 26, Mar 4, Apr 8, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2028 Sails: Jan 8, More...
Azamara Cruises, Azamara Quest
Azamara Quest10 Night - Panama, Ecuadaor & Peru Cruise : Panama City, Manta & Lima (Callao)
Starting in Panama City (Fuerte Amador), Manta, Callao (Lima), Pisco, Coquimbo, Valparaiso
2028 Sails: Jan 14, More...
Oceania Marina10 Night - Classic Canal & Tropics
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2028 Sails: Jan 16, More...
Emerald Cruises, Emerald Azzurra
Emerald Azzurra7 Night - Coastal Adventures : Panama & Costa Rica
Starting in Panama City, Panama, Pearl Islands, Panama, Playa del Muerto / Darien National Park, Panama, Isla Cebaco, Panama, Golfito, Costa Rica, Quepos, Costa Rica, Curu and Isla Tortuga, Costa Rica, Puerto Caldera, Costa Rica
2028 Sails: Jan 24, More...

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Panama Cruise Departures