Panama Cruise Departures
Cruises that depart from Central America: Panama
Cruises that visit Panama
Related areas: Balboa : Colon : Fuerte Amador : Panama City
10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Nov 13, More...
10 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...
14 Night - Panama to Antigua
Starting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, San Blas Archipelago, Panama, Cartagena De Indias, Colombia, Santa Marta, Colombia, Oranjestad, Aruba, Kralendijk, Bonaire, Willemstad AN, Curacao, St Georges, Grenada, Soufriere Bay, St Lucia, Deshaies, Guadeloupe, St Johns AG
2026 Sails: Nov 14, More...
10 Night - Secrets of Central America
Starting in Colon, Fuerte San Lorenzo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, Dec 18, 2027: Jan 14, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
10 Night - Secrets of Central America
Starting in Colon, Fuerte San Lorenzo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...7 Night - Southern Caribbean Holiday Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Dec 19, More...
8 Night - Naturally Costa Rica
Starting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
Cruises that depart from Central America: Panama
Cruises that visit Panama
Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Balboa : Colon : Fuerte Amador : Panama City
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Nov 13, More...
10 Night - Southern Caribbean CruiseStarting in Colon, Panama, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Port of Spain, Trinidad, Scarborough, Tobago, Colon, Panama
2026 Sails: Nov 14, More...
14 Night - Panama to AntiguaStarting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, San Blas Archipelago, Panama, Cartagena De Indias, Colombia, Santa Marta, Colombia, Oranjestad, Aruba, Kralendijk, Bonaire, Willemstad AN, Curacao, St Georges, Grenada, Soufriere Bay, St Lucia, Deshaies, Guadeloupe, St Johns AG
2026 Sails: Nov 14, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fuerte San Lorenzo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Nov 21, Dec 18, 2027: Jan 14, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fuerte San Lorenzo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
7 Night - Southern Caribbean Holiday CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Dec 19, More...
8 Night - Naturally Costa RicaStarting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
