Panama Cruise Departures
Cruises that depart from Central America: Panama
Cruises that visit Panama
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Apr 10, More...
11 Night - A Journey of Mayan Discovery & Mexican Exploration
Starting in Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles
2027 Sails: Apr 22, More...18 Night - An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders
Starting in Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles, San Diego, San Francisco, Victoria CA, Vancouver
2027 Sails: Apr 22, More...7 Night - Colon to San Juan Cruise
Starting in Colon, Panama, Kingstown, St Vincent, Castries, St Lucia, St Johns AG, Antigua, Tortola, San Juan, Puerto Rico
2027 Sails: Apr 24, More...
14 Night - The Americas & Caribbean
Starting in Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 20, More...
13 Night - Ancient Kingdoms and Natural Treasures : Panama to Chile
Starting in Panama City, Panama, Darien National Park / Playa del Muerto, Panama, Utria National Park / Ensenada de Utria, Colombia, Manta, Ecuador, Salaverry, Peru, Paracas, Peru, Pinguino de Humboldt National Reserve, Valparaiso, Chile
2027 Sails: Oct 31, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2027 Sails: Nov 28, More...
10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Belize City, Cozumel, Mexico, Merida (Progreso), Sail the Caribbean Sea, Fort Lauderdale, Florida
2027 Sails: Nov 29, 2028: Jan 16, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2027 Sails: Dec 2, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Dec 4, Dec 11, Dec 25, 2028: Jan 29, Feb 5, Feb 12, Mar 11, Mar 25, Apr 22, More...
Cruises that depart from Central America: Panama
Cruises that visit Panama
Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Apr 10, More...
11 Night - A Journey of Mayan Discovery & Mexican ExplorationStarting in Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles
2027 Sails: Apr 22, More...
18 Night - An Extended Journey of Ancient Mysteries & Pacific Coastal WondersStarting in Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles, San Diego, San Francisco, Victoria CA, Vancouver
2027 Sails: Apr 22, More...
7 Night - Colon to San Juan CruiseStarting in Colon, Panama, Kingstown, St Vincent, Castries, St Lucia, St Johns AG, Antigua, Tortola, San Juan, Puerto Rico
2027 Sails: Apr 24, More...
14 Night - The Americas & CaribbeanStarting in Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 20, More...
13 Night - Ancient Kingdoms and Natural Treasures : Panama to ChileStarting in Panama City, Panama, Darien National Park / Playa del Muerto, Panama, Utria National Park / Ensenada de Utria, Colombia, Manta, Ecuador, Salaverry, Peru, Paracas, Peru, Pinguino de Humboldt National Reserve, Valparaiso, Chile
2027 Sails: Oct 31, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2027 Sails: Nov 28, More...
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Belize City, Cozumel, Mexico, Merida (Progreso), Sail the Caribbean Sea, Fort Lauderdale, Florida
2027 Sails: Nov 29, 2028: Jan 16, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2027 Sails: Dec 2, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2027 Sails: Dec 4, Dec 11, Dec 25, 2028: Jan 29, Feb 5, Feb 12, Mar 11, Mar 25, Apr 22, More...
