Panama Cruise Departures
Cruises that depart from Central America: Panama
Cruises that visit Panama
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Colon / Embark Ship, Portobelo / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Pearl Islands, Playa Muerto, Darien National Park, Punta Patino Nature Reserve, Balboa / Disembark Ship / Panama City, Panama
2026 Sails: Dec 6, 2028: Mar 9, More...
10 Night - Classic Panama Canal Passage
Starting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
7 Night - Southern Caribbean Holiday Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Dec 19, More...
7 Night - Panama to Costa Rica Christmas Cruise
Starting in Balboa (Isla Flamenco), Panama, San Jose Island / Pearl Islands, Panama, Isla Iguana, Panama, Coiba National Park, Panama, Golfito, Costa Rica, Quepos, Costa Rica, Islas Tortugas, Costa Rica, Puerto Caldera, Costa Rica
2026 Sails: Dec 19, More...
8 Night - Naturally Costa Rica
Starting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2027 Sails: Jan 5, Jan 19, Feb 2, More...7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
Cruises that depart from Central America: Panama
Cruises that visit Panama
Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
7 Night - The Panama Canal, Pearl Islands and Darien JungleStarting in Panama City, Panama / Colon / Embark Ship, Portobelo / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Pearl Islands, Playa Muerto, Darien National Park, Punta Patino Nature Reserve, Balboa / Disembark Ship / Panama City, Panama
2026 Sails: Dec 6, 2028: Mar 9, More...
10 Night - Classic Panama Canal PassageStarting in Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Roatan, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, West Palm Beach, Florida
2026 Sails: Dec 17, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 18, More...
10 Night - Secrets of Central AmericaStarting in Colon, Fort San Lorenzo (Colon), San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Dec 19, More...
7 Night - Southern Caribbean Holiday CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Dec 19, More...
7 Night - Panama to Costa Rica Christmas CruiseStarting in Balboa (Isla Flamenco), Panama, San Jose Island / Pearl Islands, Panama, Isla Iguana, Panama, Coiba National Park, Panama, Golfito, Costa Rica, Quepos, Costa Rica, Islas Tortugas, Costa Rica, Puerto Caldera, Costa Rica
2026 Sails: Dec 19, More...
8 Night - Naturally Costa RicaStarting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...
10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise TourStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2027 Sails: Jan 5, Jan 19, Feb 2, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
