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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Regent Seven Seas, Seven Seas Splendor
Seven Seas Splendor28 Night - Canal to Coral Reefs
Starting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2027 Sails: Jan 30, More...
Windstar, Wind Star
Wind Star29 Night - Star Collector : Panama Canal Ocean Crossing to Tahitian Dreams
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera, Papeete
2027 Sails: Jan 31, More...
Windstar, Wind Star
Wind Star8 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera
2027 Sails: Jan 31, More...
Windstar, Wind Star
Wind Star36 Night - Star Collector : Pacific Horizons from Panama to Tahiti
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera, Papeete, Morning Sailing, Raiatea, Motu Mahaea, Near Tahaa, Bora Bora, Huahine, Moorea, Papeete
2027 Sails: Jan 31, More...
Windstar Tours, Wind Star Tours
Wind Star Tours12 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera
2027 Sails: Jan 31, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2027 Sails: Feb 13, More...
Windstar, Star Legend
Star Legend6 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Balboa / Fuerte Amador, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2027 Sails: Feb 16, More...
Windstar, Star Legend
Star Legend14 Night - Star Collector : Windward Islands & Spanish New World
Starting in Balboa / Fuerte Amador, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad, Willemstad AN, Kralendijk, St Georges, Rodney Bay, The Pitons, Mayreau, Bequia, Bridgetown
2027 Sails: Feb 16, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit13 Night - Cruise from Colon to Puntarenas
Starting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2027 Sails: Feb 17, More...

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Panama Cruise Departures