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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Windstar, Wind Star
Wind Star29 Night - Star Collector : Panama Canal Ocean Crossing to Tahitian Dreams
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera, Papeete
2027 Sails: Jan 31, More...
Windstar, Wind Star
Wind Star8 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera
2027 Sails: Jan 31, More...
Windstar, Wind Star
Wind Star36 Night - Star Collector : Pacific Horizons from Panama to Tahiti
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera, Papeete, Morning Sailing, Raiatea, Motu Mahaea, Near Tahaa, Bora Bora, Huahine, Moorea, Papeete
2027 Sails: Jan 31, More...
Windstar Tours, Wind Star Tours
Wind Star Tours12 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Puerto Caldera
2027 Sails: Jan 31, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2027 Sails: Feb 13, More...
Windstar, Star Legend
Star Legend6 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Balboa / Fuerte Amador, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2027 Sails: Feb 16, More...
Windstar, Star Legend
Star Legend14 Night - Star Collector : Windward Islands & Spanish New World
Starting in Balboa / Fuerte Amador, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad, Willemstad AN, Kralendijk, St Georges, Rodney Bay, The Pitons, Mayreau, Bequia, Bridgetown
2027 Sails: Feb 16, More...
Sea Cloud, Sea Cloud Spirit
Sea Cloud Spirit12 Night - Cruise from Colon to Puntarenas
Starting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2027 Sails: Feb 17, More...
Regent Seven Seas, Seven Seas Prestige
Seven Seas Prestige11 Night - Crescent Beaches & Colorful Towns
Starting in Panama City, Panama Canal Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Cozumel, Mexico, George Town, Montego Bay, Cruising the Straits of Florida, Miami
2027 Sails: Feb 22, More...
PONANT, Le Laperouse
Le Laperouse7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2027 Sails: Feb 26, More...

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Panama Cruise Departures