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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Windstar Tours, Wind Star Tours
Wind Star Tours10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2026 Sails: Dec 19, 2027: Jan 2, More...
Lindblad Expeditions, National Geographic Quest
National Geographic Quest7 Night - Costa Rica and the Panama Canal
Starting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2026 Sails: Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, More...
Windstar, Star Legend
Star Legend8 Night - Naturally Costa Rica
Starting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...
Windstar, Star Legend
Star Legend7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
Windstar Tours, Star Legend Tours
Star Legend Tours10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2027 Sails: Jan 5, Jan 19, Feb 2, More...
Oceania Cruises, Oceania Marina
Oceania Marina10 Night - Panama to Caribbean Joy
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Falmouth, George Town, Miami
2027 Sails: Jan 15, More...
PONANT, Le Laperouse
Le Laperouse7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Portobelo, Crossing the Panama Canal, Playa Muerto, Darien National Park, Golfito, Puntarenas
2027 Sails: Jan 15, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Jan 16, More...
Star Clippers, Star Clipper
Star Clipper11 Night - Panama to Aruba
Starting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, Portobelo, Panama, San Blas Archipelago, Panama, Cartagena De Indias, Colombia, Santa Marta, Colombia, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba
2027 Sails: Jan 16, More...
Royal Caribbean, Grandeur of the Seas
Grandeur of the Seas7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Jan 23, More...

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Panama Cruise Departures