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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

PONANT, Le Champlain
Le Champlain Cruises12 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, Portobelo, San Blas Islands, Cartagena, Santa Marta, Bonaire, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Mar 25, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Mar 28, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia Cruise Ship10 Night - Classic Canal & Tropics
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Apr 4, More...
Scenic Luxury Cruises, Scenic Eclipse II
Scenic Eclipse II Cruises11 Night - Panama Canal & the Alluring Islands of the Caribbean
Starting in Panama City, Panama, Panama Canal Transit, Portobelo, Panama, Cayos Limones, San Blas Islands, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Klein Curacao, Curacao, Tobago Cays, St Vincent and the Grenadines, Bridgetown, Barbados
2026 Sails: Apr 13, More...
Windstar Cruises, Star Seeker
Star Seeker Cruises15 Night - Star Collector : Panama Canal, Costa Rica & Mexican Riviera Discovery
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Curu, Costa Rica, Playas del Coco, Puerto Chiapas, Huatulco, Manzanillo, Puerto Vallarta
2026 Sails: Apr 13, More...
Windstar Cruises, Star Seeker
Star Seeker Cruises7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2026 Sails: Apr 13, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship1 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO
2026 Sails: Apr 18, More...
Oceania Cruises, Oceania Insignia
Oceania Insignia Cruise Ship10 Night - Canal & Coral Isles
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Puerto Limon, Roatan, Costa Maya, Mexico, Cozumel, Mexico, Miami
2026 Sails: Apr 24, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship10 Night - Panama Canal Westward Cruise
Starting in Colon, Panama, Panama Canal (Cruising), Puntarenas, Costa Rica, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 25, More...
Royal Caribbean International, Grandeur of the Seas
Grandeur of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: May 9, May 16, May 23, May 30, Jun 6, Jun 13, Jun 20, Jun 27, Jul 4, Jul 11, Jul 18, Jul 25, Aug 1, Aug 8, Aug 15, Aug 22, Aug 29, Sep 12, Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, Oct 24, More...

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Panama Cruise Departures