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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Windstar Cruises, Star Pride
Star Pride Cruises6 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Balboa, Panama City, Panama Canal, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Jan 11, More...
Regent Seven Seas Cruises, Seven Seas Grandeur
Seven Seas Grandeur Cruises10 Night - Tropical Tastes of the Riviera
Starting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Ensenada, Los Angeles
2026 Sails: Jan 15, More...
PONANT, Le Dumont-D'Urville
Le Dumont-D'Urville Cruises12 Night - Panama, Colombia & Caribbean Islands
Starting in Colon, Portobelo, San Blas Islands, Cartagena CO, Santa Marta, Willemstad AN, Mayreau Island, Union Island, Pigeon Island Beach, Soufriere, Les Saintes, Fort-de-France
2026 Sails: Jan 16, More...
PONANT, Le Champlain
Le Champlain Cruises10 Night - Secrets of Central America
Starting in Colon, Fuerte San Lorenzo, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Coiba Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Jan 19, Mar 5, More...
Royal Caribbean International (RCL), RCL Serenade of the Seas
RCL Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2026 Sails: Jan 24, Jan 31, Feb 7, More...
Windstar Cruises, Star Pride
Star Pride Cruises8 Night - Mind, Body and Spirit Collection : Naturally Costa Rica
Starting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Jan 25, More...
Oceania Cruises, Oceania Nautica
Oceania Nautica Cruise Ship10 Night - Canal & Caribbean Discovery
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 27, More...
Windstar Cruises, Wind Surf
Wind Surf Cruise Ship19 Night - Star Collector : Caribbean Cultures : Latin America & the Greater Antilles
Starting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico, Grand Cayman, Cayman Brac, Ocho Rios, Jamaica, Santo Domingo, La Romana, Jost Van Dyke, Great Harbour, Virgin Gorda / Prickly Pear, British Virgin Islands, Philipsburg, St Maarten
2026 Sails: Feb 9, More...
Windstar Cruises, Wind Surf
Wind Surf Cruise Ship8 Night - James Beard Foundation : Mayan Legacies
Starting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico
2026 Sails: Feb 9, More...
Royal Caribbean International (RCL), RCL Serenade of the Seas
RCL Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Feb 14, Mar 21, Apr 4, More...

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Panama Cruise Departures