Panama Cruise Departures
Cruises that depart from Central America: Panama
Cruises that visit Panama
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - Costa Rica and the Panama Canal
Starting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2026 Sails: Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, More...
8 Night - Naturally Costa Rica
Starting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise Tour
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2027 Sails: Jan 5, Jan 19, Feb 2, More...
10 Night - Panama to Caribbean Joy
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Kralendijk, Falmouth, George Town, Miami
2027 Sails: Jan 15, More...
7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Portobelo, Crossing the Panama Canal, Playa Muerto, Darien National Park, Golfito, Puntarenas
2027 Sails: Jan 15, More...
7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Jan 16, More...
11 Night - Panama to Aruba
Starting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, Portobelo, Panama, San Blas Archipelago, Panama, Cartagena De Indias, Colombia, Santa Marta, Colombia, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba
2027 Sails: Jan 16, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Jan 23, More...
28 Night - Canal to Coral Reefs
Starting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Kahului, Honolulu, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
Cruises that depart from Central America: Panama
Cruises that visit Panama
Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - Costa Rica and the Panama CanalStarting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2026 Sails: Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, More...
8 Night - Naturally Costa RicaStarting in Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 20, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera
2027 Sails: Jan 5, Jan 19, Feb 2, More...
10 Night - Monteverde Cloud Forest & Arenal Volcano Cruise TourStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Puerto Caldera, Santa Elena (Monteverde), La Fortuna (Arenal), Costa Rica, Puerto Caldera, San Jose, Costa Rica
2027 Sails: Jan 5, Jan 19, Feb 2, More...
10 Night - Panama to Caribbean JoyStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Kralendijk, Falmouth, George Town, Miami
2027 Sails: Jan 15, More...
7 Night - Central America Jewels & Panama CanalStarting in Colon, San Blas Islands, Portobelo, Crossing the Panama Canal, Playa Muerto, Darien National Park, Golfito, Puntarenas
2027 Sails: Jan 15, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Jan 16, More...
11 Night - Panama to ArubaStarting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, Portobelo, Panama, San Blas Archipelago, Panama, Cartagena De Indias, Colombia, Santa Marta, Colombia, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba
2027 Sails: Jan 16, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2027 Sails: Jan 23, More...
28 Night - Canal to Coral ReefsStarting in Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Kahului, Honolulu, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti)
2027 Sails: Jan 26, More...
