Panama Cruise Departures
Cruises that depart from Central America: Panama
Cruises that visit Panama
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - The Panama Canal, Pearl Islands and Darien Jungle
Starting in Panama City, Panama / Balboa / Embark Ship, Punta Patino Nature Reserve, Playa Muerto, Darien National Park, Pearl Islands / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Portobelo, Colon / Disembark Ship / Panama City, Panama
2025 Sails: Dec 14, 2026: Jan 16, Dec 13, 2027: Jan 29, Nov 5, 2028: Jan 29, Mar 16, More...
7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2025 Sails: Dec 19, More...
7 Night - Southern Caribbean Holiday
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2025 Sails: Dec 20, More...7 Night - Costa Rica and the Panama Canal
Starting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2025 Sails: Dec 21, 2026: Jan 23, Feb 11, Mar 2, Mar 21, Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, Apr 6, More...7 Night - Southern Caribbean Holiday
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2025 Sails: Dec 27, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal, Balboa / Fuerte Amador, Golfo Dulce (Puerto Jimenez), Isla Partida, Quepos, Puerto Caldera
2025 Sails: Dec 27, More...7 Night - Central America Jewels & Panama Canal
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Jan 2, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Colon, Panama
2026 Sails: Jan 3, Feb 21, Feb 28, More...
14 Night - Panama to Jamaica
Starting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, Portobelo, Panama, Bocas Del Toro, Panama, Puerto Limon, Costa Rica, Cove Bay / San Andres, Colombia, Providencia, Colombia, George Town, Grand Cayman, Cayman Brac, Cayman Islands, Montego Bay, Jamaica
2026 Sails: Jan 3, More...7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Jan 10, Mar 7, More...
Cruises that depart from Central America: Panama
Cruises that visit Panama
Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Balboa : Colon : Fuerte Amador : Panama City
7 Night - The Panama Canal, Pearl Islands and Darien JungleStarting in Panama City, Panama / Balboa / Embark Ship, Punta Patino Nature Reserve, Playa Muerto, Darien National Park, Pearl Islands / Panama Canal Transit, Gatun Lake / Panama Canal Transit, Portobelo, Colon / Disembark Ship / Panama City, Panama
2025 Sails: Dec 14, 2026: Jan 16, Dec 13, 2027: Jan 29, Nov 5, 2028: Jan 29, Mar 16, More...
7 Night - Central America Jewels & Panama CanalStarting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2025 Sails: Dec 19, More...
7 Night - Southern Caribbean HolidayStarting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2025 Sails: Dec 20, More...
7 Night - Costa Rica and the Panama CanalStarting in Panama City, Panama / Colon / Embark Ship, Gatun Lake / Panama Canal Transit, Gulf of Panama Islets, Coiba National Park, Panama, Golfo Dulce / Osa Peninsula, Corcovado National Park, Puerto Caldera / Disembark Ship / San Jose
2025 Sails: Dec 21, 2026: Jan 23, Feb 11, Mar 2, Mar 21, Dec 20, 2027: Jan 3, Feb 6, Feb 20, Mar 6, Mar 20, Dec 4, Dec 23, 2028: Jan 6, Feb 5, Feb 19, Mar 23, Apr 6, More...
7 Night - Southern Caribbean HolidayStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Kralendijk, Bonaire, Colon, Panama
2025 Sails: Dec 27, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal, Balboa / Fuerte Amador, Golfo Dulce (Puerto Jimenez), Isla Partida, Quepos, Puerto Caldera
2025 Sails: Dec 27, More...
7 Night - Central America Jewels & Panama CanalStarting in Colon, San Blas Islands, Crossing the Panama Canal, Fuerte Amador, Flamenco Island, Playa Muerto, Darien National Park, Golfito, Puntarenas
2026 Sails: Jan 2, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Colon, Panama
2026 Sails: Jan 3, Feb 21, Feb 28, More...
14 Night - Panama to JamaicaStarting in Balboa (Isla Flamenco), Panama, Panama Canal Transit, Portobelo, Panama, Bocas Del Toro, Panama, Puerto Limon, Costa Rica, Cove Bay / San Andres, Colombia, Providencia, Colombia, George Town, Grand Cayman, Cayman Brac, Cayman Islands, Montego Bay, Jamaica
2026 Sails: Jan 3, More...
7 Night - Southern Caribbean CruiseStarting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Jan 10, Mar 7, More...
