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Panama Cruise Departures

Cruises that depart from Central America: Panama

Cruises that visit Panama

Click on a cruise ship itinerary sailing from Panama (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Balboa : Colon : Fuerte Amador : Panama City

Departing from
Panama
Cruise Specials

Windstar Cruises, Wind Surf
Wind Surf Cruise Ship19 Night - Star Collector : Caribbean Cultures : Latin America & the Greater Antilles
Starting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico, Grand Cayman, Cayman Brac, Ocho Rios, Jamaica, Santo Domingo, La Romana, Jost Van Dyke, Great Harbour, Virgin Gorda / Prickly Pear, British Virgin Islands, Philipsburg, St Maarten
2026 Sails: Feb 9, More...
Windstar Cruises, Wind Surf
Wind Surf Cruise Ship8 Night - James Beard Foundation : Mayan Legacies
Starting in Colon, Bocas del Toro, Isla San Andres, Roatan, Belize City, Costa Maya, Mexico, Cozumel, Mexico
2026 Sails: Feb 9, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Feb 14, Mar 21, Apr 4, More...
Sea Cloud Cruises, Sea Cloud Spirit
Sea Cloud Spirit Cruises13 Night - Cruise from Colon to Puntarenas
Starting in Colon, San Blas Islands, Transit Panama Canal, Pearl Islands, Puerto Jimenez, Playa Mantas / Punta Leona, Quepos, Marina Flamingo / Playa Flamingo, Playa Panama, Puntarenas
2026 Sails: Feb 17, More...
PONANT, Le Champlain
Le Champlain Cruises7 Night - Panama and Costa Rica by Sea : the Natural Wonders of Central America - with Smithsonian Journeys
Starting in Colon, San Blas Islands, Crossing the Panama Canal, Playa Muerto, Darien National Park, Fuerte Amador, Flamenco Island, Quepos, Puntarenas
2026 Sails: Feb 19, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Colon, Panama
2026 Sails: Feb 21, Feb 28, More...
PONANT, Le Champlain
Le Champlain Cruises10 Night - Secrets of Central America
Starting in Colon, Fort San Lorenzo (Colon), Colon, San Blas Islands, Crossing the Panama Canal, Pearls Islands, Pacheca Island, Playa Muerto, Darien National Park, Cebaco Island, Rio Esquinas, Drake Bay, Curu Wildlife Refuge, Puntarenas
2026 Sails: Mar 5, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama
2026 Sails: Mar 7, More...
Windstar Cruises, Star Pride
Star Pride Cruises6 Night - Panama's Pristine Caribbean
Starting in Colon, Bocas del Toro, San Blas, Panama, Cartagena CO, Oranjestad
2026 Sails: Mar 9, More...
Royal Caribbean International, Serenade of the Seas
Serenade of the Seas Cruise Ship7 Night - Southern Caribbean Cruise
Starting in Colon, Panama, Cartagena CO, Willemstad AN, Curacao, Oranjestad, Aruba, Colon, Panama
2026 Sails: Mar 14, Apr 11, More...

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Panama Cruise Departures