Louisiana Cruise Departures
Cruises that depart from North America: United States: Louisiana
Cruises that visit Louisiana
See all River Cruises that depart from Louisiana
Related areas: New Orleans
22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 9, More...
14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, 2028: Jul 11, More...
11 Night - Mississippi River Gateway Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, More...14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jul 18, More...
7 Night - Western Caribbean
Starting in New Orleans, La, Isla Tropicale, Roatan, Belize, Cozumel, Mexico, New Orleans, La
2026 Sails: Jul 26, Sep 6, Sep 20, Oct 18, Nov 1, Dec 27, 2027: Jan 3, Jan 10, Feb 7, Feb 21, Feb 28, Mar 7, Mar 28, Apr 4, Apr 18, Apr 25, May 2, May 16, May 30, Jun 13, Jun 27, Jul 11, Jul 25, Aug 8, More...7 Night - Highlights of the Mississippi Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Oct 9, 2027: Feb 13, Oct 28, Nov 3, More...10 Night - New Orleans to Memphis
Starting in New Orleans, Louisiana, Darrow, Louisiana, Baton Rouge, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Oct 17, More...11 Night - Mississippi Explorer Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, St Francisville, LA, Natchez, MS, Day of Cruising, Vicksburg, MS, Day of River Cruising, Cleveland, MS, Tunica, MS, Memphis, TN
2026 Sails: Oct 29, 2027: Oct 8, 2028: Sep 22, Oct 10, Oct 27, More...
6 Night - Western Caribbean Cruise
Starting in New Orleans, Louisiana, Puerto Costa Maya, Mexico, Belize City, Belize, Cozumel, Mexico, New Orleans, Louisiana
2026 Sails: Nov 1, More...7 Night - Western Caribbean Cruise
Starting in New Orleans, Louisiana, Cozumel, Mexico, George Town, Grand Cayman, Falmouth, Jamaica, New Orleans, Louisiana
2026 Sails: Nov 7, Nov 14, Nov 21, Nov 28, Dec 12, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Feb 6, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 17, More...
Cruises that depart from North America: United States: Louisiana
Cruises that visit Louisiana
See all River Cruises that depart from Louisiana
Click on a cruise ship itinerary sailing from Louisiana (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisiana), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: New Orleans
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 9, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, 2028: Jul 11, More...
11 Night - Mississippi River Gateway CruiseStarting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jul 18, More...
7 Night - Western CaribbeanStarting in New Orleans, La, Isla Tropicale, Roatan, Belize, Cozumel, Mexico, New Orleans, La
2026 Sails: Jul 26, Sep 6, Sep 20, Oct 18, Nov 1, Dec 27, 2027: Jan 3, Jan 10, Feb 7, Feb 21, Feb 28, Mar 7, Mar 28, Apr 4, Apr 18, Apr 25, May 2, May 16, May 30, Jun 13, Jun 27, Jul 11, Jul 25, Aug 8, More...
7 Night - Highlights of the Mississippi CruiseStarting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Oct 9, 2027: Feb 13, Oct 28, Nov 3, More...
10 Night - New Orleans to MemphisStarting in New Orleans, Louisiana, Darrow, Louisiana, Baton Rouge, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Oct 17, More...
11 Night - Mississippi Explorer CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, St Francisville, LA, Natchez, MS, Day of Cruising, Vicksburg, MS, Day of River Cruising, Cleveland, MS, Tunica, MS, Memphis, TN
2026 Sails: Oct 29, 2027: Oct 8, 2028: Sep 22, Oct 10, Oct 27, More...
6 Night - Western Caribbean CruiseStarting in New Orleans, Louisiana, Puerto Costa Maya, Mexico, Belize City, Belize, Cozumel, Mexico, New Orleans, Louisiana
2026 Sails: Nov 1, More...
7 Night - Western Caribbean CruiseStarting in New Orleans, Louisiana, Cozumel, Mexico, George Town, Grand Cayman, Falmouth, Jamaica, New Orleans, Louisiana
2026 Sails: Nov 7, Nov 14, Nov 21, Nov 28, Dec 12, Dec 26, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Feb 6, Mar 6, Mar 13, Mar 20, Mar 27, Apr 3, Apr 17, More...
