Louisiana Cruise Departures
Cruises that depart from North America: United States: Louisiana
Cruises that visit Louisiana
See all River Cruises that depart from Louisiana
Related areas: New Orleans
8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Oct 15, 2027: Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Nov 9, Nov 23, Dec 7, 2028: Feb 19, Mar 4, Mar 18, Apr 1, More...
7 Night - Mississippi Delta Explorer
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Feb 21, Mar 7, Mar 21, Apr 4, Apr 18, May 2, May 16, May 30, Sep 19, Oct 3, Dec 1, 2027: Feb 9, Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 18, Jun 1, Oct 12, Nov 23, Dec 7, More...
14 Night - Caribbean
Starting in New Orleans, La, Costa Maya, Mexico, Harvest Caye, Belize, Roatan Bay Islands, Honduras, Puerto Limon, Costa Rica, Colon, Panama, Cartagena CO, Montego Bay, Jamaica, George Town, Cayman Islands, Cozumel, Mexico, New Orleans, La
2026 Sails: Feb 22, More...
8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 24, Mar 10, Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, Jul 14, Nov 3, 2027: Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 4, May 18, Jun 1, Jun 15, Jun 29, Jul 13, Nov 2, 2028: Feb 23, Mar 8, More...
7 Night - Gulf Coast Cruise
Starting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, More...
7 Night - Western Caribbean
Starting in New Orleans, La, Mahogany Bay, Roatan, Belize, Cozumel, Mexico, New Orleans, La
2026 Sails: Mar 8, Apr 5, More...7 Night - Western Caribbean - New Orleans
Starting in New Orleans, La, Cozumel, Mexico, Harvest Caye, Belize, Roatan Bay Islands, Honduras, Costa Maya, Mexico, New Orleans, La
2026 Sails: Mar 8, More...
11 Night - Mississippi Explorer Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Day of River Cruising, Cleveland, MS, Tunica, MS, Memphis, TN
2026 Sails: Mar 18, Apr 7, More...7 Night - Western Caribbean
Starting in New Orleans, La, Cozumel, Mexico, Belize, Mahogany Bay, Roatan, New Orleans, La
2026 Sails: Mar 22, May 3, More...7 Night - Western Caribbean - New Orleans
Starting in New Orleans, La, Costa Maya, Mexico, Harvest Caye, Belize, Roatan Bay Islands, Honduras, Cozumel, Mexico, New Orleans, La
2026 Sails: Mar 22, More...
Cruises that depart from North America: United States: Louisiana
Cruises that visit Louisiana
See all River Cruises that depart from Louisiana
Click on a cruise ship itinerary sailing from Louisiana (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Louisiana), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: New Orleans
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Oct 15, 2027: Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Nov 9, Nov 23, Dec 7, 2028: Feb 19, Mar 4, Mar 18, Apr 1, More...
7 Night - Mississippi Delta ExplorerStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Feb 21, Mar 7, Mar 21, Apr 4, Apr 18, May 2, May 16, May 30, Sep 19, Oct 3, Dec 1, 2027: Feb 9, Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 18, Jun 1, Oct 12, Nov 23, Dec 7, More...
14 Night - CaribbeanStarting in New Orleans, La, Costa Maya, Mexico, Harvest Caye, Belize, Roatan Bay Islands, Honduras, Puerto Limon, Costa Rica, Colon, Panama, Cartagena CO, Montego Bay, Jamaica, George Town, Cayman Islands, Cozumel, Mexico, New Orleans, La
2026 Sails: Feb 22, More...
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 24, Mar 10, Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, Jul 14, Nov 3, 2027: Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 4, May 18, Jun 1, Jun 15, Jun 29, Jul 13, Nov 2, 2028: Feb 23, Mar 8, More...
7 Night - Gulf Coast CruiseStarting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, More...
7 Night - Western CaribbeanStarting in New Orleans, La, Mahogany Bay, Roatan, Belize, Cozumel, Mexico, New Orleans, La
2026 Sails: Mar 8, Apr 5, More...
7 Night - Western Caribbean - New OrleansStarting in New Orleans, La, Cozumel, Mexico, Harvest Caye, Belize, Roatan Bay Islands, Honduras, Costa Maya, Mexico, New Orleans, La
2026 Sails: Mar 8, More...
11 Night - Mississippi Explorer CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Day of River Cruising, Cleveland, MS, Tunica, MS, Memphis, TN
2026 Sails: Mar 18, Apr 7, More...
7 Night - Western CaribbeanStarting in New Orleans, La, Cozumel, Mexico, Belize, Mahogany Bay, Roatan, New Orleans, La
2026 Sails: Mar 22, May 3, More...
7 Night - Western Caribbean - New OrleansStarting in New Orleans, La, Costa Maya, Mexico, Harvest Caye, Belize, Roatan Bay Islands, Honduras, Cozumel, Mexico, New Orleans, La
2026 Sails: Mar 22, More...
