Mississippi River Cruises
River Cruises sailing on the Mississippi River
River cruises by river name
Cruises on the Mississippi River also sail:
Arkansas River : Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : Tennessee River : US South Coast
15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
7 Night - Heartland of America
Starting in Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Aug 1, 2028: Jul 25, More...7 Night - Heartland of America
Starting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri (Alton)
2026 Sails: Aug 8, Aug 22, 2027: Aug 31, Sep 14, 2028: Sep 5, Sep 19, More...8 Night - Upper Mississippi River Cruise
Starting in St Louis, MO / Alton, IL, Cruising the Mississippi River, Hannibal, MO, Day of Cruising, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, 2027: Jul 30, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, 2028: Jul 1, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, More...7 Night - Heartland of America
Starting in St Louis, Missouri (Alton), Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Aug 15, Aug 29, 2027: Jul 20, Aug 24, Sep 7, Sep 21, 2028: Aug 29, Sep 12, Sep 26, More...
15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...8 Night - Upper Mississippi River Cruise
Starting in St Louis, MO / Alton, IL, Cruising the Mississippi River, Hannibal, MO, Day of Cruising, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Sep 4, More...14 Night - America's Great River
Starting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Sep 5, 2027: Jul 27, Sep 28, 2028: Aug 1, Oct 3, More...15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...
15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...
River Cruises sailing on the Mississippi River
Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Mississippi River also sail:
Arkansas River : Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : Tennessee River : US South Coast
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
7 Night - Heartland of AmericaStarting in Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Aug 1, 2028: Jul 25, More...
7 Night - Heartland of AmericaStarting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri (Alton)
2026 Sails: Aug 8, Aug 22, 2027: Aug 31, Sep 14, 2028: Sep 5, Sep 19, More...
8 Night - Upper Mississippi River CruiseStarting in St Louis, MO / Alton, IL, Cruising the Mississippi River, Hannibal, MO, Day of Cruising, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, 2027: Jul 30, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, 2028: Jul 1, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, More...
7 Night - Heartland of AmericaStarting in St Louis, Missouri (Alton), Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Aug 15, Aug 29, 2027: Jul 20, Aug 24, Sep 7, Sep 21, 2028: Aug 29, Sep 12, Sep 26, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...
8 Night - Upper Mississippi River CruiseStarting in St Louis, MO / Alton, IL, Cruising the Mississippi River, Hannibal, MO, Day of Cruising, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Sep 4, More...
14 Night - America's Great RiverStarting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Sep 5, 2027: Jul 27, Sep 28, 2028: Aug 1, Oct 3, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...
