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Ohio River Cruises

Cruises sailing on the Ohio River


Click on a cruise ship itinerary sailing on the Ohio River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ohio River), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Cruises on the Ohio River also sail: Cumberland River : Lake Barkley : Licking River : Mississippi River : Olentangy River : Tennessee River


America Cruises10 Night Mississippi River Gateway Cruise from St. Louis to New Orleans
Starting in St. Louis, MO; with stops in Paducah, KY; New Madrid, MO; Memphis, TN; Vicksburg, MS, Natchez, MS; Baton Rouge, LA; New Orleans, LA
2019 Sails: Jul 24, More...
Queen of the Mississippi Cruises10 Night Ohio River Cruise from Pittsburgh, PA to St. Louis
Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2019 Sails: Jul 25, 2020: Jul 3, Jul 23, More...
American Duchess Cruises8 Night Ohio and Tennessee River Lewis and Clark Cruise from Louisville to St. Louis
Starting in Louisville; with stops in Brandenburg, KY; Owensboro, KY; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO
2019 Sails: Jul 28, More...
America Cruises21 Night Complete Mississippi River Cruise from New Orleans, LA to St. Paul, MN
Staring in New Orleans, LA; with stops in Oak Alley, Baton Rouge, St. Francisville, Natchez, Vicksburg, Memphis, Cape Girardeau, St. Louis, Hannibal, La Crosse, Red Wing
2019 Sails: Aug 3, 2020: Aug 6, More...
American Harmony Cruises10 Night Mississippi River Gateway Cruise St Louis, Missouri to New Orleans, Louisiana
Starting in St Louis, with stops in Cruising the Ohio River, Paducah, New Madrid, Memphis, Cruising the Mississippi River, Vicksburg, Natchez, Baton Rouge, New Orleans
2019 Sails: Aug 14, Oct 29, 2020: Jul 1, Jul 21, Sep 28, Nov 11, More...
Queen of the Mississippi Cruises10 Night Mississippi River Gateway Cruise from New Orleans to St. Louis
Starting in New Orleans, LA; with stops in Baton Rouge, LA; Natchez, MS; Vicksburg, MS; Memphis, TN; New Madrid, MO; Paducah, KY; St. Louis, MO
2019 Sails: Aug 14, 2020: Jul 13, Aug 12, More...
American Duchess Cruises22 Night The Mighty Mississippi River Cruise from St. Paul to New Orleans
Starting in St. Paul, MN; with stops in Red Wing, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; Alton, IL; St. Louis, MO; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Memphis, TN; Helena, AR; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; St. Francisville, LA; Nottoway Plantation, LA; New Orleans
2019 Sails: Aug 18, More...
America Cruises10 Night Mississippi River Gateway Cruise from New Orleans to St. Louis
Starting in New Orleans, LA; with stops in Baton Rouge, LA; Natchez, MS; Vicksburg, MS; Memphis, TN; New Madrid, MO; Paducah, KY; St. Louis, MO
2019 Sails: Sep 7, 2020: Sep 10, More...
Queen of the Mississippi Cruises7 Night Cumberland River Cruise from St. Louis to Nashville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN; Nashville, TN
2019 Sails: Sep 7, Sep 21, 2020: Sep 5, Sep 19, More...
Queen of the Mississippi Cruises7 Night Cumberland River and Mississippi River from Nashville, Tennessee to St. Louis, Missouri
Starting in Nashville, TN; with stops in Clarksville, TN; Dover; TN; Paducah, Kentucky; Cape Girardeau, MO; Chester, IL; St. Louis, Missouri
2019 Sails: Sep 14, Sep 28, 2020: Sep 12, Sep 26, More...


Ohio River Cruises
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