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Ohio River Cruises

Cruises sailing on the Ohio River


Click on a cruise ship itinerary sailing on the Ohio River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ohio River), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Cruises on the Ohio River also sail: Cumberland River : Lake Barkley : Licking River : Mississippi River : Olentangy River : Tennessee River




American Countess Cruises7 Night - Civil War Cruise form Chattanooga to Memphis
Starting in Chattanooga; with stops in Decatur, AL; Florence, AL; Savannah, TN; Paducah, KY; New Madrid, MO; Memphis, TN
2020 Sails: Nov 1, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Memphis to Nashville (Clarksville)
Starting in Memphis, TN; with stops in Ashport Landing, TN; New Madrid, MO; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN
2021 Sails: Apr 4, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Nashville (Clarksville) to St. Louis
Starting in Nashville, TN; with stops in Clarksville, TN; Dover, TN; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO
2021 Sails: Apr 11, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from St. Louis to Cincinnati
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Madison, IN; Cincinnati, OH
2021 Sails: Apr 18, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Cincinnati to Louisville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Owensboro, KY; Louisville, KY
2021 Sails: Apr 25, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Louisville to St. Louis
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2021 Sails: May 2, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from St. Louis to Memphis
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2021 Sails: May 9, Oct 3, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Memphis to Louisville
Starting in Memphis, TN; with stops in Columbus, KY; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2021 Sails: May 30, Aug 22, Sep 19, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Louisville to Pittsburgh
Starting in Louisville, KY; with stops in Madison, IN; Cincinnati, OH; Maysville, KY; Point Pleasant, WV; Marietta, OH; Pittsburgh, PA
2021 Sails: Jun 6, More...
American Duchess Cruises8 Night - Ohio River and Tennessee River Cruise from Pittsburgh to Louisville
Starting in Pittsburgh, PA; with stops in Wheeling, WV; Marietta, OH; Huntington, WV; Augusta, KY; Cincinnati, OH; Madison, IN; Louisville, KY
2021 Sails: Jun 13, More...


Ohio River Cruises
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