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Ohio River Cruises

Cruises sailing on the Ohio River


Click on a cruise ship itinerary sailing on the Ohio River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ohio River), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Cruises on the Ohio River also sail: Cumberland River : Lake Barkley : Licking River : Mississippi River : Olentangy River : Tennessee River


Queen of the Mississippi Cruises7 Night Cumberland River and Mississippi River from Nashville, Tennessee to St. Louis, Missouri
Starting in Nashville, TN; with stops in Clarksville, TN; Dover; TN; Paducah, Kentucky; Cape Girardeau, MO; Chester, IL; St. Louis, Missouri
2019 Sails: Sep 28, 2020: Sep 12, Sep 26, More...
American Harmony Cruises10 Night Mississippi River Gateway Cruise New Orleans, Louisiana to St Louis, Missouri
Starting in New Orleans, with stops in Baton Rouge, Natchez, Vicksburg, Cruising the Mississippi River, Memphis, New Madrid, Paducah, Cruising the Ohio River, St Louis
2019 Sails: Oct 19, 2020: Jun 21, Jul 11, Sep 18, Nov 12, More...
American Queen Cruises8 Night Ohio and Tennessee River Civil War Cruise from Memphis to Chattanooga
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Savannah, TN; Florence, AL; Chattanooga, TN
2019 Sails: Oct 27, More...
American Harmony Cruises10 Night Mississippi River Gateway Cruise St Louis, Missouri to New Orleans, Louisiana
Starting in St Louis, with stops in Cruising the Ohio River, Paducah, New Madrid, Memphis, Cruising the Mississippi River, Vicksburg, Natchez, Baton Rouge, New Orleans
2019 Sails: Oct 29, 2020: Jul 1, Jul 21, Sep 28, Nov 11, More...
American Queen Cruises8 Night Ohio and Tennessee River Civil War Cruise from Chattanooga to Memphis
Starting in Chattanooga; with stops in Decatur, AL; Florence, AL; Savannah, TN; Paducah, KY; New Madrid, MO; Memphis, TN
2019 Sails: Nov 3, More...
American Duchess Cruises8 Night Ohio and Tennessee River American Music Holiday from Memphis to Nashville
Starting in Memphis; with stops in Paducah, KY; Grand Rivers, KY; Clarksville, TN; Nashville, TN
2019 Sails: Dec 1, More...
American Duchess Cruises8 Night Ohio and Tennessee River American Music Holiday from Nashville, to Memphis
Starting in Nashville; with stops in Clarksville, TN; Dover, TN; Paducah, KY; New Madrid, MO; Memphis, TN
2019 Sails: Dec 8, More...
American Duchess Cruises8 Night Civil War Cruise from Memphis to Clarksville
Starting in Memphis; with stops in Ashport Landing, TN; New Madrid, MO; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN
2020 Sails: Apr 5, More...
American Duchess Cruises8 Night Music of America Cruise from Clarksville to St. Louis
Starting in Clarksville; with stops in Dover, TN; Paducah, KY; Cape Girardeau, MO; Chester, IL; Alton, IL; St. Louis, MO
2020 Sails: Apr 12, More...
American Duchess Cruises8 Night American Culinary Experience from St. Louis to Cincinnati
Starting in St Louis; with stops in Cape Girardeau; Paducah; Bradenburg; Louisville; Madison
2020 Sails: Apr 19, More...


Ohio River Cruises
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