Mississippi River Cruises
River Cruises sailing on the Mississippi River
River cruises by river name
Cruises on the Mississippi River also sail:
Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : US South Coast
8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Jun 9, 2027: Jun 8, Jun 22, Oct 8, 2028: Jun 7, Jun 21, Oct 7, More...
8 Night - Music Cities Cruise
Starting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Jun 9, Jun 23, Jul 21, 2027: Jul 20, 2028: Jul 19, More...
8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jun 12, Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 11, Sep 3, Sep 17, Oct 1, 2028: Jun 24, Sep 2, Sep 16, Sep 30, More...
22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 10, More...
14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, More...8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 16, Jun 30, Oct 20, 2027: Oct 19, 2028: Oct 18, More...15 Night - Grand Ohio River Cruise
Starting in St Louis, MO, Cruising the Mississippi River, Paducah, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Louisville, KY, Madison, IN, Cincinnati, OH, Day of Cruising, Maysville, KY, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jun 19, 2027: Jun 18, 2028: Jul 1, More...11 Night - Mississippi River Gateway Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA / Houmas House, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, 2027: Jun 29, 2028: Jun 28, More...
8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Aug 18, Oct 27, 2027: Jun 22, Nov 5, 2028: Jun 21, Nov 4, More...8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, 2027: Jul 9, Jul 23, Aug 6, Aug 20, 2028: Jul 8, Jul 22, Aug 5, Aug 19, More...
River Cruises sailing on the Mississippi River
Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Mississippi River also sail:
Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : US South Coast
8 Night - Lower Mississippi River CruiseStarting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Jun 9, 2027: Jun 8, Jun 22, Oct 8, 2028: Jun 7, Jun 21, Oct 7, More...
8 Night - Music Cities CruiseStarting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Jun 9, Jun 23, Jul 21, 2027: Jul 20, 2028: Jul 19, More...
8 Night - Upper Mississippi River CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jun 12, Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 11, Sep 3, Sep 17, Oct 1, 2028: Jun 24, Sep 2, Sep 16, Sep 30, More...
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 10, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, More...
8 Night - Music Cities CruiseStarting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 16, Jun 30, Oct 20, 2027: Oct 19, 2028: Oct 18, More...
15 Night - Grand Ohio River CruiseStarting in St Louis, MO, Cruising the Mississippi River, Paducah, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Louisville, KY, Madison, IN, Cincinnati, OH, Day of Cruising, Maysville, KY, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jun 19, 2027: Jun 18, 2028: Jul 1, More...
11 Night - Mississippi River Gateway CruiseStarting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA / Houmas House, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, 2027: Jun 29, 2028: Jun 28, More...
8 Night - Music Cities CruiseStarting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Aug 18, Oct 27, 2027: Jun 22, Nov 5, 2028: Jun 21, Nov 4, More...
8 Night - Ohio River CruiseStarting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, 2027: Jul 9, Jul 23, Aug 6, Aug 20, 2028: Jul 8, Jul 22, Aug 5, Aug 19, More...
