US South Coast Cruises

River Cruises sailing on the US South Coast

Click on a cruise ship itinerary sailing on the US South Coast (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just US South Coast), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the US South Coast also sail:
Mississippi River : St Johns River : Tolomato River : US East Coast

American Cruise Lines, American Maverick

15 Night - Grand Florida Coast & Keys Cruise
Starting in Amelia Island, FL, Day of Cruising, Green Cove Springs, FL, St Augustine, FL, Cruising the Tolomato River, Cape Canaveral, FL, Day of Cruising, West Palm Beach, FL, Key Biscayne, FL, Key West, FL, Day of Cruising, Marco Island, FL, Punta Gorda, FL, St Petersburg FL
2026 Sails: Oct 20, 2027: Nov 7, 2028: Nov 20, More...

American Cruise Lines, American Maverick

8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2026 Sails: Nov 3, Nov 10, Nov 17, Nov 24, Dec 1, Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Jan 19, Jan 26, Feb 2, Feb 9, Feb 16, Feb 23, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, Apr 13, More...

American Cruise Lines, American Symphony

7 Night - Gulf Coast Cruise
Starting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Nov 10, Dec 8, Dec 20, 2027: Feb 12, Feb 24, Mar 8, Mar 20, Apr 1, Dec 10, Dec 22, 2028: Feb 20, Mar 3, Mar 15, Mar 27, More...

American Cruise Lines, American Symphony

7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Nov 16, Dec 14, Dec 26, 2027: Feb 18, Mar 2, Mar 14, Mar 26, Apr 7, Dec 16, Dec 28, 2028: Feb 26, Mar 9, Mar 21, Apr 2, More...

American Cruise Lines, American Maverick

15 Night - Grand Florida Coast & Keys Cruise
Starting in Tampa, FL / St Petersburg FL, Day of Cruising, Punta Gorda, FL, Marco Island, FL, Day of Cruising, Key West, FL, Key Biscayne, FL, West Palm Beach, FL, Cape Canaveral, FL, Day of Cruising, Green Cove Springs, FL, St Augustine, FL, Cruising the Tolomato River, Amelia Island, FL
2027 Sails: Apr 20, 2028: Apr 30, More...

American Cruise Lines, American Navigator

8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2027 Sails: Nov 26, Dec 3, Dec 10, Dec 17, Dec 24, Dec 31, 2028: Jan 7, Jan 14, Jan 21, Jan 28, Feb 4, Feb 11, Feb 18, Feb 25, Mar 3, Mar 10, Mar 17, Mar 24, Mar 31, Nov 18, Nov 25, Dec 2, Dec 9, Dec 16, More...

American Cruise Lines, American Navigator