US South Coast Cruises
River Cruises sailing on the US South Coast
River cruises by river name
Cruises on the US South Coast also sail: Mississippi River : US East Coast
8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2025 Sails: Dec 19, Dec 26, 2026: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, More...
8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2025 Sails: Dec 21, Dec 28, 2026: Jan 4, Jan 11, Jan 18, Jan 25, Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, Apr 12, Apr 19, 2027: Jan 3, Jan 10, Jan 17, Jan 24, Jan 31, Feb 7, More...
8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2025 Sails: Dec 23, Dec 30, 2026: Jan 6, Jan 13, Jan 20, Jan 27, Feb 3, Feb 10, Feb 17, Feb 24, Mar 3, Mar 10, Mar 17, More...
7 Night - Gulf Coast Cruise
Starting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, More...7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Mar 7, Mar 19, More...
8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2026 Sails: Nov 3, Nov 10, Nov 17, Nov 24, Dec 1, Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Jan 19, Jan 26, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, Apr 13, Nov 21, Nov 28, Dec 5, Dec 12, More...
8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2026 Sails: Dec 7, Dec 14, Dec 21, Dec 28, More...
7 Night - Gulf Coast Cruise
Starting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Dec 21, 2028: Mar 3, Mar 27, Dec 21, More...7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Dec 28, 2028: Mar 9, Apr 2, Dec 27, More...
8 Night - Florida Gulf Coast & Keys Cruise
Starting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2027 Sails: Nov 26, Dec 3, Dec 10, Dec 17, Dec 24, 2028: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, More...
River Cruises sailing on the US South Coast
Click on a cruise ship itinerary sailing on the US South Coast (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just US South Coast), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the US South Coast also sail: Mississippi River : US East Coast
8 Night - Florida Gulf Coast & Keys CruiseStarting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2025 Sails: Dec 19, Dec 26, 2026: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 6, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, Nov 13, Nov 20, Nov 27, Dec 4, Dec 11, Dec 18, Dec 25, 2027: Jan 1, Jan 8, Jan 15, More...
8 Night - Florida Gulf Coast & Keys CruiseStarting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2025 Sails: Dec 21, Dec 28, 2026: Jan 4, Jan 11, Jan 18, Jan 25, Feb 1, Feb 8, Feb 15, Feb 22, Mar 1, Mar 8, Mar 15, Mar 22, Mar 29, Apr 5, Apr 12, Apr 19, 2027: Jan 3, Jan 10, Jan 17, Jan 24, Jan 31, Feb 7, More...
8 Night - Florida Gulf Coast & Keys CruiseStarting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2025 Sails: Dec 23, Dec 30, 2026: Jan 6, Jan 13, Jan 20, Jan 27, Feb 3, Feb 10, Feb 17, Feb 24, Mar 3, Mar 10, Mar 17, More...
7 Night - Gulf Coast CruiseStarting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, More...
7 Night - Gulf Coast CruiseStarting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Mar 7, Mar 19, More...
8 Night - Florida Gulf Coast & Keys CruiseStarting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2026 Sails: Nov 3, Nov 10, Nov 17, Nov 24, Dec 1, Dec 8, Dec 15, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Jan 19, Jan 26, Mar 2, Mar 9, Mar 16, Mar 23, Mar 30, Apr 6, Apr 13, Nov 21, Nov 28, Dec 5, Dec 12, More...
8 Night - Florida Gulf Coast & Keys CruiseStarting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2026 Sails: Dec 7, Dec 14, Dec 21, Dec 28, More...
7 Night - Gulf Coast CruiseStarting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Dec 21, 2028: Mar 3, Mar 27, Dec 21, More...
7 Night - Gulf Coast CruiseStarting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Dec 28, 2028: Mar 9, Apr 2, Dec 27, More...
8 Night - Florida Gulf Coast & Keys CruiseStarting in Tampa, Fl, Day of Cruising, Marco Island, FL, Key West, FL, Day of Cruising, Punta Gorda, FL, St Petersburg FL
2027 Sails: Nov 26, Dec 3, Dec 10, Dec 17, Dec 24, 2028: Jan 1, Jan 8, Jan 15, Jan 22, Jan 29, Feb 5, Feb 12, Feb 19, Feb 26, Mar 4, Mar 11, Mar 18, Mar 25, Apr 1, More...
