Mississippi River Cruises
River Cruises sailing on the Mississippi River
River cruises by river name
Cruises on the Mississippi River also sail: Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : US South Coast
8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 24, Mar 10, Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, Jul 14, Nov 3, 2027: Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 4, May 18, Jun 1, Jun 15, Jun 29, Jul 13, Nov 2, 2028: Feb 23, Mar 8, More...
7 Night - Gulf Coast Cruise
Starting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, More...8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, May 12, May 26, Jul 7, Oct 27, Nov 10, 2027: Feb 16, Mar 2, Mar 16, Mar 30, Apr 13, Apr 27, May 11, May 25, Jun 8, Jun 22, Jul 6, Oct 26, Nov 9, 2028: Feb 16, More...7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Mar 7, Mar 19, More...
11 Night - Mississippi Explorer Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Day of River Cruising, Cleveland, MS, Tunica, MS, Memphis, TN
2026 Sails: Mar 18, Apr 7, More...7 Night - Historic Mississippi River Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 25, More...
7 Night - Historic Mississippi River Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 28, Apr 3, Apr 9, Apr 15, Apr 21, Apr 27, May 3, May 9, May 15, May 21, May 27, Jun 16, Oct 12, Oct 18, Oct 24, Oct 30, Nov 5, Nov 11, Nov 17, Nov 23, Nov 29, 2027: Mar 27, Apr 2, Apr 8, More...11 Night - Mississippi Explorer Cruise
Starting in Memphis, TN, Cruising the Mississippi River, Tunica, MS, Cleveland, MS, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Natchez, MS, St Francisville, LA, Baton Rouge, LA, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Mar 28, More...8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Apr 17, May 1, May 15, Nov 6, Nov 20, Dec 5, 2027: Apr 2, Apr 16, Apr 30, May 14, Nov 5, Nov 19, Dec 27, 2028: Apr 15, Apr 29, May 13, May 27, Nov 4, Nov 18, Dec 2, More...8 Night - Music Cities Cruise
Starting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Apr 21, Jul 14, Aug 11, Sep 8, 2027: Apr 20, Oct 1, 2028: Apr 19, Sep 30, More...
River Cruises sailing on the Mississippi River
Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Mississippi River also sail: Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : US South Coast
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 24, Mar 10, Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, Jul 14, Nov 3, 2027: Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 4, May 18, Jun 1, Jun 15, Jun 29, Jul 13, Nov 2, 2028: Feb 23, Mar 8, More...
7 Night - Gulf Coast CruiseStarting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, More...
8 Night - Lower Mississippi River CruiseStarting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, May 12, May 26, Jul 7, Oct 27, Nov 10, 2027: Feb 16, Mar 2, Mar 16, Mar 30, Apr 13, Apr 27, May 11, May 25, Jun 8, Jun 22, Jul 6, Oct 26, Nov 9, 2028: Feb 16, More...
7 Night - Gulf Coast CruiseStarting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Mar 7, Mar 19, More...
11 Night - Mississippi Explorer CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Day of River Cruising, Cleveland, MS, Tunica, MS, Memphis, TN
2026 Sails: Mar 18, Apr 7, More...
7 Night - Historic Mississippi River CruiseStarting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 25, More...
7 Night - Historic Mississippi River CruiseStarting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 28, Apr 3, Apr 9, Apr 15, Apr 21, Apr 27, May 3, May 9, May 15, May 21, May 27, Jun 16, Oct 12, Oct 18, Oct 24, Oct 30, Nov 5, Nov 11, Nov 17, Nov 23, Nov 29, 2027: Mar 27, Apr 2, Apr 8, More...
11 Night - Mississippi Explorer CruiseStarting in Memphis, TN, Cruising the Mississippi River, Tunica, MS, Cleveland, MS, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Natchez, MS, St Francisville, LA, Baton Rouge, LA, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Mar 28, More...
8 Night - Lower Mississippi River CruiseStarting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Apr 17, May 1, May 15, Nov 6, Nov 20, Dec 5, 2027: Apr 2, Apr 16, Apr 30, May 14, Nov 5, Nov 19, Dec 27, 2028: Apr 15, Apr 29, May 13, May 27, Nov 4, Nov 18, Dec 2, More...
8 Night - Music Cities CruiseStarting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Apr 21, Jul 14, Aug 11, Sep 8, 2027: Apr 20, Oct 1, 2028: Apr 19, Sep 30, More...
