Mississippi River Cruises
River Cruises sailing on the Mississippi River
River cruises by river name
Cruises on the Mississippi River also sail:
Arkansas River : Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : Tennessee River : US South Coast
8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Jun 2, Sep 25, Oct 18, 2028: May 30, More...8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
2026 Sails: Jun 9, Oct 25, 2028: Jun 6, More...
8 Night - Music Cities Cruise
Starting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Jun 9, Jun 23, Jul 21, More...
8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jun 12, Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 25, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, 2028: Jun 23, Jul 8, Jul 21, Aug 4, Aug 19, Sep 1, Sep 15, More...
22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 9, More...
14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, 2028: Jul 11, More...8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 16, Jun 30, Oct 20, More...15 Night - Grand Ohio River Cruise
Starting in St Louis, MO, Cruising the Mississippi River, Paducah, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Louisville, KY, Madison, IN, Cincinnati, OH, Day of Cruising, Maysville, KY, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jun 19, 2027: Jul 2, More...11 Night - Mississippi River Gateway Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, More...
8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Oct 27, 2027: Oct 29, More...
River Cruises sailing on the Mississippi River
Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Mississippi River also sail:
Arkansas River : Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : Tennessee River : US South Coast
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Jun 2, Sep 25, Oct 18, 2028: May 30, More...
8 Night - Lower Mississippi River CruiseStarting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
2026 Sails: Jun 9, Oct 25, 2028: Jun 6, More...
8 Night - Music Cities CruiseStarting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Jun 9, Jun 23, Jul 21, More...
8 Night - Upper Mississippi River CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jun 12, Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 25, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, 2028: Jun 23, Jul 8, Jul 21, Aug 4, Aug 19, Sep 1, Sep 15, More...
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 9, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, 2028: Jul 11, More...
8 Night - Music Cities CruiseStarting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 16, Jun 30, Oct 20, More...
15 Night - Grand Ohio River CruiseStarting in St Louis, MO, Cruising the Mississippi River, Paducah, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Louisville, KY, Madison, IN, Cincinnati, OH, Day of Cruising, Maysville, KY, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jun 19, 2027: Jul 2, More...
11 Night - Mississippi River Gateway CruiseStarting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, More...
8 Night - Music Cities CruiseStarting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Oct 27, 2027: Oct 29, More...
