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Mississippi River Cruises

River Cruises sailing on the Mississippi River

Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Mississippi River also sail: Amstel River : Corrib River : Cumberland River : Danube River : Illinois River : Ireland Coast : Lake Barkley : Licking River : Liffey River : Loch Lomond : Lough Leane : Main River : Ness River : Ohio River : Olentangy River : Ouse River : Rhine River : Salzach River : Tennessee River : Water of Leith River


American Jazz Cruises7 Night - Music Cities Cruise from Memphis, TN to Nashville, TN
Starting in Memphis TN; Cruising the Mississippi and Ohio River; with stops in Paducah, KY; Cruising Lake Barkley and the Cumberland River; Dover, TN; Clarksville, TN; Nashville, TN
2021 Sails: Aug 1, Aug 15, Aug 29, Sep 12, 2022: Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, 2023: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, More...
American Duchess Cruises15 Night - Minneapolis (Red Wing) to New Orleans
Starting in Minneapolis, MN; with stops in Red Wing, MN; Winona, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Nottoway; New Orleans, LA
2021 Sails: Aug 1, 2022: Sep 24, 2023: Sep 16, More...
Queen of the Mississippi Cruises7 Night - Upper Mississippi River Cruise from St. Paul, MN to St. Louis, MO
Starting in St. Paul, MN; with stops in Red Wing, MN; Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO
2021 Sails: Aug 3, More...
America Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Aug 4, Sep 4, Sep 18, Oct 2, Oct 16, 2022: Jul 20, Aug 3, Sep 3, Sep 17, Oct 1, Oct 15, 2023: Jul 19, Aug 2, Sep 2, Sep 16, Sep 30, Oct 14, More...
American Countess Cruises8 Night - New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: Aug 7, Sep 11, Oct 23, Dec 4, Dec 18, 2022: Mar 14, Mar 28, Apr 11, Oct 10, Nov 14, 2023: Mar 6, Mar 20, Apr 3, Apr 17, Sep 18, Nov 6, Nov 20, Dec 4, More...
American Jazz Cruises7 Night - Music Cities Cruise from Nashville, TN to Memphis, TN
Starting in Nashville, TN; with stops in Clarksville, TN; Dover, TN; Cruising Lake Barkley and the Cumberland River; Paducah, KY; Cruising the Mississippi and Ohio River; Memphis TN
2021 Sails: Aug 8, Aug 22, Sep 5, Sep 19, 2022: Jul 10, Jul 24, Aug 7, Aug 21, Sep 4, Sep 18, 2023: Jul 9, Jul 23, Aug 6, Aug 20, Sep 3, Sep 17, More...
American Queen Cruises8 Night - New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: Aug 8, Sep 5, Sep 19, Oct 3, Oct 17, Nov 14, 2022: Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Sep 25, Nov 27, 2023: Feb 12, Feb 26, Mar 5, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, More...
Queen of the Mississippi Cruises10 Night - Ohio River Cruise from St. Louis to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2021 Sails: Aug 10, Aug 30, Sep 19, 2022: Aug 6, Aug 26, Sep 15, 2023: Aug 5, Aug 25, More...
America Cruises14 Night - Grand Heartland Cruise from St. Paul, MN to New Orleans, LA
Starting in St. Paul, MN; with stops in Red Wing, MN;Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; New Orleans, LA
2021 Sails: Aug 11, Oct 23, 2022: Aug 10, Oct 22, 2023: Aug 9, Oct 21, More...
American Countess Cruises8 Night - American Culinary Experience River Cruise from Memphis to St. Louis (Alton)
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO (Alton)
2021 Sails: Aug 14, More...


Mississippi River Cruises

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