Mississippi River Cruises

River Cruises sailing on the Mississippi River

Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Mississippi River also sail:
Arkansas River : Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : Tennessee River : US South Coast

American Cruise Lines, American Heritage

11 Night - Mississippi River Gateway Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, More...

American Cruise Lines, American Splendor

8 Night - Music Cities Cruise
Starting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
2026 Sails: Jun 23, Jul 21, More...

American Cruise Lines, American Symphony

8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
2026 Sails: Jun 23, Aug 4, Oct 27, 2027: Oct 29, More...

Viking River, Viking Mississippi

7 Night - Heartland of America
Starting in Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Jun 27, 2028: Jul 25, More...

American Cruise Lines, American Splendor

American Cruise Lines, American Symphony

8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
2026 Sails: Jun 30, Aug 11, Aug 25, Nov 3, 2027: Nov 19, Dec 3, 2028: Nov 7, More...

American Cruise Lines, American Heritage

8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 2, Jul 17, Jul 31, Aug 14, More...

American Cruise Lines, American Melody

8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, More...

American Cruise Lines, American Serenade

8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, 2027: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 30, Jul 14, Jul 28, Aug 11, More...

American Cruise Lines, American Splendor

8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
2026 Sails: Jul 7, Oct 27, Nov 10, 2027: Feb 16, Mar 2, Mar 16, Mar 30, Apr 13, Apr 27, May 11, May 25, Jun 8, Jun 22, Jul 6, Oct 12, Oct 26, Nov 9, 2028: Feb 15, Feb 29, Mar 14, Mar 28, Apr 11, Apr 25, May 9, More...

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