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Mississippi River Cruises

River Cruises sailing on the Mississippi River

Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Mississippi River also sail: Amstel River : Corrib River : Cumberland River : Danube River : Illinois River : Ireland Coast : Lake Barkley : Licking River : Liffey River : Loch Lomond : Lough Leane : Main River : Ness River : Ohio River : Olentangy River : Ouse River : Rhine River : Salzach River : Tennessee River : Water of Leith River


Queen of the Mississippi Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Valley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis TN
2021 Sails: Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Nov 13, Nov 27, 2022: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Jun 18, Jul 2, Oct 15, Oct 29, Nov 12, Nov 26, 2023: Feb 11, Feb 25, More...
American Countess Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from Memphis to New Orleans
Starting in Memphis, TN; with stops in Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Nottoway; New Orleans, LA
2021 Sails: Apr 24, Jun 19, Jul 31, 2022: Nov 7, 2023: Mar 27, Apr 10, Apr 24, Sep 25, Oct 30, Nov 13, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from Memphis, TN to New Orleans, LA
Starting in Memphis TN; with stops in Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Oak Valley, LA; New Orleans, LA
2021 Sails: Apr 25, May 9, May 23, Jun 6, Jun 20, Sep 26, Oct 17, Oct 31, Nov 14, Nov 28, Dec 12, Dec 28, 2022: Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Sep 25, Oct 16, Oct 30, More...
American Duchess Cruises8 Night - Special Edition Voyages - Special Events - The Kentucky Derby™ Cruise from Cincinnati to Louisville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Owensboro, KY; Louisville, KY
2021 Sails: Apr 25, More...
American Duchess Cruises8 Night - Ohio River - The Beautiful Ohio Cruise from Cincinnati to Louisville
Starting in Cincinnati, OH; with stops in Madison, IN; Louisville, KY; Brandenburg, KY; Owensboro, KY; Louisville, KY
2021 Sails: Apr 25, More...
America Cruises7 Night - Mississippi River Cruise Roundtrip from New Orleans, LA
Starting in New Orleans, LA; with stops in Oak Alley, LA; Natchez, MS; Vicksburg, MS; St. Francisville, LA; Baton Rouge, LA; Houmas House, LA; New Orleans, LA
2021 Sails: Apr 27, May 4, May 11, May 18, May 25, Jun 1, Jun 8, Jun 15, Jun 22, Nov 6, Nov 21, 2022: Feb 20, Feb 27, Mar 6, Mar 13, Apr 5, Apr 12, Apr 19, Apr 26, May 3, May 10, May 17, May 24, May 31, More...
Queen of the Mississippi Cruises7 Night - Lower Mississippi River Cruise from Memphis, TN to New Orleans, LA
Starting in Memphis TN; with stops in Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Oak Valley, LA; New Orleans, LA
2021 Sails: May 1, May 15, May 29, Jun 12, Jun 26, Jul 10, Nov 20, Dec 4, 2022: Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Jun 11, Jun 25, Jul 9, Oct 22, Nov 5, Nov 19, Dec 3, 2023: Mar 4, Mar 18, More...
American Countess Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: May 1, May 15, Jun 26, Jul 10, Jul 24, Aug 7, Sep 11, Oct 23, 2022: Mar 14, Mar 28, Apr 11, Oct 10, Nov 14, 2023: Mar 20, Apr 3, Apr 17, Sep 18, Nov 6, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Alley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis, TN
2021 Sails: May 2, May 16, May 30, Jun 13, Jun 27, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 20, 2022: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Oct 9, Oct 23, 2023: Feb 19, More...
American Duchess Cruises8 Night - Special Edition Voyages - Special Events - Founders Cruise from Louisville to St. Louis, MO (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: May 2, More...


Mississippi River Cruises

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