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Mississippi River Cruises

Cruises sailing on the Mississippi River


Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Cruises on the Mississippi River also sail: Amstel River : Corrib River : Cumberland River : Danube River : Ireland Coast : Lake Barkley : Licking River : Liffey River : Loch Lomond : Lough Leane : Main River : Ness River : Ohio River : Ouse River : Rhine River : Salzach River : Tennessee River : Water of Leith River




American Duchess Cruises8 Night - Music of America Cruise from Clarksville to St. Louis
Starting in Clarksville; with stops in Dover, TN; Paducah, KY; Cape Girardeau, MO; Chester, IL; Alton, IL; St. Louis, MO
2020 Sails: Apr 12, More...
American Countess Cruises7 Night - Antebellum South from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway Plantation; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2020 Sails: Apr 19, May 3, May 17, Jul 19, Aug 2, Aug 16, Oct 4, Oct 18, Nov 15, More...
American Duchess Cruises8 Night - American Culinary Experience from St. Louis to Cincinnati
Starting in St Louis; with stops in Cape Girardeau; Paducah; Bradenburg; Louisville; Madison
2020 Sails: Apr 19, More...
American Queen Cruises8 Night - Antebellum South Cruise from New Orleans to Memphis
Starting in New Orleans; with stops in Nottoway Plantation; St. Francisville; Natchez; Vicksburg; Tunica, MS; Memphis, TN
2020 Sails: Apr 19, May 3, May 17, May 31, Jun 14, Jun 28, Jul 12, Aug 30, Sep 13, Sep 27, Oct 11, Oct 25, Nov 8, Nov 22, Dec 6, More...
America Cruises7 Night - Mississippi River from Memphis, TN to New Orleans, LA
Starting in Memphis, Tennessee; with stops in Vicksburg, Mississippi; Natchez, Mississippi; St. Francisville, Louisiana; Baton Rouge, Louisiana; Oak Alley, Louisiana; New Orleans, Louisiana
2020 Sails: Apr 25, May 16, May 30, Jun 13, Jun 27, 2021: Jun 20, More...
American Harmony Cruises7 Night - Lower Mississippi River Cruise from Memphis, Tennessee New Orleans, Louisiana
Starting in Memphis, with stops in Cruising the Mississippi River, Vicksburg, Natchez, St Francisville, Baton Rouge, Oak Alley, New Orleans
2020 Sails: Apr 26, May 17, May 31, Jun 14, Oct 15, Oct 29, More...
American Countess Cruises7 Night - Antebellum South from Memphis to New Orleans
Starting in Memphis, TN; with stops in Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; St. Francisville, LA; Nottoway Plantation; New Orleans, LA
2020 Sails: Apr 26, May 10, Jul 12, Jul 26, Aug 9, Oct 11, Nov 8, Nov 22, More...
American Duchess Cruises8 Night - Kentucky Derby Cruise from Cincinnati to Louisville
Starting in Cincinnati; with stops in Madison, IN; Louisville, KY; Bradenburg, KY; Owensboro, KY; Louisville, KY
2020 Sails: Apr 26, More...
American Queen Cruises8 Night - Antebellum South Cruise from Memphis to New Orleans
Starting in Memphis; with stops in Vicksburg, MS; Natchez, MS; Baton Rouge, LA; St. Francisville, LA; Nottoway Plantation, LA; New Orleans, LA
2020 Sails: Apr 26, May 10, May 24, Jun 7, Jun 21, Jul 5, Sep 6, Sep 20, Oct 4, Oct 18, Nov 1, Nov 29, Dec 13, More...
Queen of the Mississippi Cruises7 Night - Mississippi River from New Orleans, LA to Memphis, TN
Starting in New Orleans, Louisiana; with stops in Oak Alley, Louisiana; Baton Rouge, Louisiana; St. Francisville, Louisiana; Natchez, Mississippi; Vicksburg, Mississippi; Memphis, Tennessee
2020 Sails: May 2, May 16, May 30, Oct 31, Nov 14, 2021: Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Jul 17, Nov 13, Nov 27, More...


Mississippi River Cruises
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