Mississippi River Cruises
River Cruises sailing on the Mississippi River
River cruises by river name
Cruises on the Mississippi River also sail: Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : US South Coast
8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2025 Sails: Dec 19, 2026: Jan 3, Apr 7, Jun 30, Aug 25, Nov 3, Nov 17, Dec 1, Dec 15, Dec 29, 2027: Feb 17, Mar 3, Apr 6, Jun 29, Nov 12, 2028: Jun 28, Nov 11, Nov 25, Dec 9, More...8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2025 Sails: Dec 26, 2026: Mar 31, Apr 14, Jul 7, Sep 1, Nov 10, Nov 24, Dec 8, Dec 22, Dec 24, 2027: Feb 10, Feb 24, Mar 30, Apr 13, Sep 24, 2028: Sep 23, Nov 18, Dec 2, More...
7 Night - New Orleans & Southern Charms
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Jan 3, Jan 10, Jan 17, Jan 24, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Dec 28, More...7 Night - New Orleans & Southern Charms
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Jan 31, 2027: Jan 19, More...7 Night - Mississippi Delta Explorer
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Feb 7, 2027: Jan 26, More...
8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Feb 13, Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Oct 22, 2027: Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Nov 16, Nov 30, Dec 14, 2028: Feb 12, Feb 26, More...7 Night - Mississippi Delta Explorer
Starting in Memphis, Tennessee, Scenic Sailing Lower Mississippi, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, St Francisville, Louisiana, Baton Rouge, Louisiana, Darrow, Louisiana, New Orleans, Louisiana
2026 Sails: Feb 14, Feb 28, Mar 14, Mar 28, Apr 11, Apr 25, May 9, May 23, Jun 6, Sep 26, Oct 10, Nov 24, Dec 8, 2027: Feb 2, Feb 16, Mar 2, Mar 16, Mar 30, Apr 13, May 11, May 25, Jun 22, Nov 16, Nov 30, More...
7 Night - Historic Mississippi River Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Feb 16, Feb 22, Feb 28, Mar 6, Mar 12, 2027: Feb 18, Feb 24, Mar 2, Mar 8, Mar 14, Mar 20, Nov 26, Dec 2, Dec 8, Dec 14, 2028: Feb 20, Feb 26, Mar 15, Mar 21, Dec 9, Dec 15, More...8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Oct 15, 2027: Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Nov 9, Nov 23, Dec 7, 2028: Feb 19, Mar 4, Mar 18, Apr 1, More...7 Night - Mississippi Delta Explorer
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Feb 21, Mar 7, Mar 21, Apr 4, Apr 18, May 2, May 16, May 30, Sep 19, Oct 3, Dec 1, 2027: Feb 9, Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 18, Jun 1, Oct 12, Nov 23, Dec 7, More...
River Cruises sailing on the Mississippi River
Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
Cruises on the Mississippi River also sail: Cumberland River : Lake Barkley : Lake Erie : Licking River : Ohio River : US South Coast
8 Night - Lower Mississippi River CruiseStarting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2025 Sails: Dec 19, 2026: Jan 3, Apr 7, Jun 30, Aug 25, Nov 3, Nov 17, Dec 1, Dec 15, Dec 29, 2027: Feb 17, Mar 3, Apr 6, Jun 29, Nov 12, 2028: Jun 28, Nov 11, Nov 25, Dec 9, More...
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2025 Sails: Dec 26, 2026: Mar 31, Apr 14, Jul 7, Sep 1, Nov 10, Nov 24, Dec 8, Dec 22, Dec 24, 2027: Feb 10, Feb 24, Mar 30, Apr 13, Sep 24, 2028: Sep 23, Nov 18, Dec 2, More...
7 Night - New Orleans & Southern CharmsStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Jan 3, Jan 10, Jan 17, Jan 24, Dec 22, Dec 29, 2027: Jan 5, Jan 12, Dec 28, More...
7 Night - New Orleans & Southern CharmsStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Baton Rouge, Louisiana, New Orleans, Louisiana
2026 Sails: Jan 31, 2027: Jan 19, More...
7 Night - Mississippi Delta ExplorerStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Feb 7, 2027: Jan 26, More...
8 Night - Lower Mississippi River CruiseStarting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA / Houmas House, LA, New Orleans, La
2026 Sails: Feb 13, Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Oct 22, 2027: Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Nov 16, Nov 30, Dec 14, 2028: Feb 12, Feb 26, More...
7 Night - Mississippi Delta ExplorerStarting in Memphis, Tennessee, Scenic Sailing Lower Mississippi, Greenville, Mississippi, Vicksburg, Mississippi, Natchez, Mississippi, St Francisville, Louisiana, Baton Rouge, Louisiana, Darrow, Louisiana, New Orleans, Louisiana
2026 Sails: Feb 14, Feb 28, Mar 14, Mar 28, Apr 11, Apr 25, May 9, May 23, Jun 6, Sep 26, Oct 10, Nov 24, Dec 8, 2027: Feb 2, Feb 16, Mar 2, Mar 16, Mar 30, Apr 13, May 11, May 25, Jun 22, Nov 16, Nov 30, More...
7 Night - Historic Mississippi River CruiseStarting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Feb 16, Feb 22, Feb 28, Mar 6, Mar 12, 2027: Feb 18, Feb 24, Mar 2, Mar 8, Mar 14, Mar 20, Nov 26, Dec 2, Dec 8, Dec 14, 2028: Feb 20, Feb 26, Mar 15, Mar 21, Dec 9, Dec 15, More...
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Oct 15, 2027: Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, May 14, May 28, Nov 9, Nov 23, Dec 7, 2028: Feb 19, Mar 4, Mar 18, Apr 1, More...
7 Night - Mississippi Delta ExplorerStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee
2026 Sails: Feb 21, Mar 7, Mar 21, Apr 4, Apr 18, May 2, May 16, May 30, Sep 19, Oct 3, Dec 1, 2027: Feb 9, Feb 23, Mar 9, Mar 23, Apr 6, Apr 20, May 18, Jun 1, Oct 12, Nov 23, Dec 7, More...
