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Mississippi River Cruises

River Cruises sailing on the Mississippi River

Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Mississippi River also sail: Amstel River : Corrib River : Cumberland River : Danube River : Illinois River : Ireland Coast : Lake Barkley : Licking River : Liffey River : Loch Lomond : Lough Leane : Main River : Ness River : Ohio River : Olentangy River : Ouse River : Rhine River : Salzach River : Tennessee River : Water of Leith River


American Jazz Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Alley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis, TN
2021 Sails: Nov 7, Nov 21, Dec 5, Dec 20, 2022: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Oct 9, Oct 23, Nov 6, Nov 20, 2023: Feb 19, Mar 5, Mar 19, Apr 2, Apr 16, Apr 30, More...
American Duchess Cruises8 Night - Memphis to New Orleans
Starting in Memphis, TN; with stops in Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Nottoway; New Orleans, LA
2021 Sails: Nov 7, Dec 19, 2022: Mar 12, Mar 26, Apr 9, Apr 23, Jun 18, Nov 12, 2023: Mar 18, Apr 1, Apr 15, Apr 29, May 13, May 27, Jun 10, Nov 18, Dec 2, Dec 16, More...
American Queen Cruises8 Night - Autumn on the River Cruise from Memphis to Chattanooga
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Savannah, TN; Decatur, AL; Chattanooga, TN
More...
American Queen Cruises8 Night - Memphis to Chattanooga
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Savannah, TN; Decatur, AL; Chattanooga, TN
More...
American Melody Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Oct 29, 2022: Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, Oct 28, More...
Queen of the Mississippi Cruises7 Night - New Orleans Roundtrip Cruise from New Orleans, LA
Starting in New Orleans, LA; with stops in Oak Alley, LA; Natchez, MS; Vicksburg, MS; St. Francisville, LA; Baton Rouge, LA; Houmas House, LA; New Orleans, LA
2021 Sails: Oct 30, Nov 6, Dec 20, Dec 28, 2022: Jul 16, Dec 21, Dec 29, 2023: Jul 15, More...
American Countess Cruises8 Night - Civil War: A Historical Perspective River Cruise from Memphis to Chattanooga
Starting in Memphis, TN; with stops in New Madrid, MO; Paducah, KY; Savannah, TN; Decatur, AL; Chattanooga, TN
2021 Sails: Oct 30, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from Memphis, TN to New Orleans, LA
Starting in Memphis TN; with stops in Vicksburg, MS; Natchez, MS; St. Francisville, LA; Baton Rouge, LA; Oak Valley, LA; New Orleans, LA
2021 Sails: Oct 31, Nov 14, Nov 28, Dec 12, Dec 28, 2022: Feb 27, Mar 13, Mar 27, Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Sep 25, Oct 16, Oct 30, Nov 13, Nov 27, 2023: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, More...
American Duchess Cruises8 Night - New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: Oct 31, Nov 28, 2022: Mar 19, Apr 2, Apr 16, Apr 30, Jun 25, Oct 8, Dec 31, 2023: Mar 11, Mar 25, Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Sep 30, Nov 11, Nov 25, Dec 9, Dec 23, More...
American Queen Cruises8 Night - Civil War: A Historical Perspective River Cruise from Chattanooga to Memphis
Starting in Chattanooga; with stops in Decatur, AL; Florence, AL; Savannah, TN; Paducah, KY; New Madrid, MO; Memphis, TN
2021 Sails: Oct 31, More...


Mississippi River Cruises

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