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Mississippi River Cruises

Cruises sailing on the Mississippi River


Click on a cruise ship itinerary sailing on the Mississippi River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mississippi River), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Cruises on the Mississippi River also sail: Amstel River : Corrib River : Cumberland River : Danube River : Illinois River : Ireland Coast : Lake Barkley : Licking River : Liffey River : Loch Lomond : Lough Leane : Main River : Ness River : Ohio River : Olentangy River : Ouse River : Rhine River : Salzach River : Tennessee River : Water of Leith River




American Harmony Cruises10 Night - Mississippi River Gateway Cruise New Orleans, Louisiana to St Louis, Missouri
Starting in New Orleans, with stops in Baton Rouge, Natchez, Vicksburg, Cruising the Mississippi River, Memphis, New Madrid, Paducah, Cruising the Ohio River, St Louis
2020 Sails: Sep 18, Nov 12, More...
Queen of the Mississippi Cruises7 Night - Cumberland River Cruise from St. Louis to Nashville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN; Nashville, TN
2020 Sails: Sep 19, More...
America Cruises7 Night - Mississippi River from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Davenport, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN; St. Paul, MN
2020 Sails: Sep 20, Oct 4, Oct 18, 2021: Jul 21, Aug 4, Sep 4, Sep 18, Oct 2, Oct 16, More...
American Countess Cruises14 Night - The Mighty Mississippi Cruise from Red Wing to New Orleans
Starting in Red Wing, MN; with stops in Winona, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Nottoway Plantation; New Orleans, LA
2020 Sails: Sep 20, More...
American Duchess Cruises8 Night - American Music Cruise from Clarksville to Memphis
Starting in Clarksville; with stops in Dover, TN; Paducah, KY; Cape Girardeau, MO; New Madrid, MO; Memphis
2020 Sails: Sep 20, More...
American Queen Cruises8 Night - Antebellum South Cruise from Memphis to New Orleans
Starting in Memphis; with stops in Vicksburg, MS; Natchez, MS; Baton Rouge, LA; St. Francisville, LA; Nottoway Plantation, LA; New Orleans, LA
2020 Sails: Sep 20, Oct 4, Oct 18, Nov 1, Nov 29, Dec 13, More...
Queen of the Mississippi Cruises7 Night - Cumberland River and Mississippi River from Nashville, Tennessee to St. Louis, Missouri
Starting in Nashville, TN; with stops in Clarksville, TN; Dover; TN; Paducah, Kentucky; Cape Girardeau, MO; Chester, IL; St. Louis, Missouri
2020 Sails: Sep 26, More...
America Cruises7 Night - Upper Mississippi River from St. Paul, MN to St. Louis, MO
Starting in St. Paul, MN; with stops in Red Wing, MN; La Crosse, WI; Dubuque, IA; Davenport, IA; Hannibal, MO; St. Louis, MO
2020 Sails: Sep 27, Oct 11, 2021: Jul 28, Sep 11, Sep 25, Oct 9, More...
American Duchess Cruises8 Night - American River BBQ Challenge Cruise from Memphis to Alton
Starting in Memphis; with stops in New Madrid, MO; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO; Alton, IL
2020 Sails: Sep 27, More...
American Queen Cruises8 Night - Antebellum South Cruise from New Orleans to Memphis
Starting in New Orleans; with stops in Nottoway Plantation; St. Francisville; Natchez; Vicksburg; Tunica, MS; Memphis, TN
2020 Sails: Sep 27, Oct 11, Oct 25, Nov 8, Nov 22, Dec 6, More...


Mississippi River Cruises
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