United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Alabama : Alaska : Florida : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Washington : Washington DC : Wisconsin : Wyoming

15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...

American Cruise Lines, American Splendor

8 Night - Tennessee Rivers Cruise
Starting in Chattanooga, TN, Cruising the Tennessee River, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, 2027: Aug 3, Aug 17, Aug 31, Sep 14, 2028: Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...

Viking River, Viking Mississippi

7 Night - Heartland of America
Starting in St Paul, Minnesota, Red Wing, Minnesota, La Crosse, Wisconsin, Dubuque, Iowa, Quad Cities, Iowa, Burlington, Iowa, Hannibal, Missouri, St Louis, Missouri (Alton)
2026 Sails: Aug 8, Aug 22, 2027: Aug 31, Sep 14, More...

American Lines Tours, American Splendor Tours

11 Night - Smoky Mountains National Park
Starting in Nashville, TN, Afternoon of Cruising, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL, Chattanooga, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Knoxville, TN
2026 Sails: Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, More...

American Cruise Lines, American Melody

8 Night - Upper Mississippi River Cruise
Starting in St Louis, MO / Alton, IL, Cruising the Mississippi River, Hannibal, MO, Day of Cruising, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, 2027: Jul 30, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, 2028: Jul 1, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, More...

American Lines Tours, American Splendor Tours

11 Night - Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...

Viking River, Viking Mississippi

7 Night - Heartland of America
Starting in St Louis, Missouri (Alton), Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Aug 15, Aug 29, 2027: Jul 20, Aug 24, Sep 7, Sep 21, More...

American Cruise Lines, American Heritage

American Cruise Lines, American Maverick

11 Night - New England Explorer Cruise
Starting in Boston, Ma, Day of Cruising, Portland ME, Rockland, ME, Bar Harbor, Me, Boothbay Harbor, ME, Bath, ME, Gloucester, MA, Newport, Ri, Day of Cruising, Marthas Vineyard, MA, Boston, Ma
2026 Sails: Aug 29, Sep 8, Sep 18, Sep 28, 2027: Jun 8, More...

American Cruise Lines, American Heritage

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United States River Cruise Departures