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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just United States), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Related areas: Alabama : Florida : Illinois : Kentucky : Louisiana : Maine : Maryland : Massachusetts : Minnesota : Missouri : New York : Oklahoma : Oregon : Pennsylvania : Rhode Island : South Carolina : Tennessee : Washington : Washington DC : Wyoming


American Cruise Lines, American Heritage
American Heritage15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...
American Cruise Lines, American Eagle
American Eagle8 Night - Hudson River Fall Foliage Cruise
Starting in New York, NY, Day of Cruising the Hudson River, Sleepy Hollow, NY, West Point, NY, Kingston, NY / Hyde Park, NY, Catskill, NY, Day of Cruising, Albany NY
2026 Sails: Sep 21, Oct 5, Oct 19, 2027: Oct 4, Oct 18, 2028: Oct 2, Oct 16, More...
American Cruise Lines, American Legend
American Legend8 Night - Northeast Harbors Cruise
Starting in Boston, Ma, Day of Cruising, Plymouth, MA, Newport, Ri, New London / Mystic, CT, Sag Harbor, NY, Old Saybrook, CT, New York, NY
2026 Sails: Sep 24, 2027: Jun 5, Jul 18, 2028: Jun 16, Jul 21, More...
American Cruise Lines, American Serenade
American Serenade15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...
American Cruise Lines, American Liberty
American Liberty8 Night - Hudson River Fall Foliage Cruise
Starting in New York, NY, Day of Cruising the Hudson River, Sleepy Hollow, NY, West Point, NY, Kingston, NY / Hyde Park, NY, Catskill, NY, Day of Cruising, Albany NY
2026 Sails: Sep 26, Oct 10, More...
American Cruise Lines, American Legend
American Legend8 Night - Hudson River Fall Foliage Cruise
Starting in New York, NY, Day of Cruising the Hudson River, Sleepy Hollow, NY, West Point, NY, Kingston, NY / Hyde Park, NY, Catskill, NY, Day of Cruising, Albany NY
2026 Sails: Oct 1, Oct 15, 2027: Sep 25, Oct 9, Oct 23, 2028: Sep 29, Oct 13, More...
American Cruise Lines, American Heritage
American Heritage11 Night - Mississippi Explorer Cruise
Starting in Memphis, TN, Cruising the Mississippi River, Tunica, MS, Day of River Cruising, Cleveland, MS, Vicksburg, MS, Day of River Cruising, Natchez, MS, St Francisville, LA, Oak Alley, LA, New Orleans, La
2026 Sails: Oct 2, More...
American Cruise Lines, American Liberty
American Liberty8 Night - Hudson River Fall Foliage Cruise
Starting in Albany NY, Cruising the Hudson River, Catskill, NY, Kingston, NY / Hyde Park, NY, Day of Cruising, West Point, NY, Sleepy Hollow, NY, New York, NY
2026 Sails: Oct 3, Oct 17, More...
American Cruise Lines, American Legend
American Legend8 Night - Hudson River Fall Foliage Cruise
Starting in Albany NY, Cruising the Hudson River, Catskill, NY, Kingston, NY / Hyde Park, NY, Day of Cruising, West Point, NY, Sleepy Hollow, NY, New York, NY
2026 Sails: Oct 8, Oct 22, 2027: Oct 2, Oct 16, Oct 30, 2028: Oct 6, Oct 20, More...
American Cruise Lines, American Maverick
American Maverick8 Night - Northeast Harbors Cruise
Starting in Boston, Ma, Day of Cruising, Plymouth, MA, Newport, Ri, New London / Mystic, CT, Sag Harbor, NY, Old Saybrook, CT, New York, NY
2026 Sails: Oct 8, 2027: Oct 25, More...

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United States River Cruise Departures