CruiseCompete: Easily Compare Multiple Offers from Cruise Experts
Compare offers from multiple travel agencies
1
Find your cruise
& request quotes
2
Compare members only prices,
upgrades, cabin credits & more!
3
Contact your preferred agent
for questions or to book your cruise
Over 1 million members
St Louis Cruise Departures

Cruises that depart from North America: United States: Missouri: St Louis

Cruises that visit St Louis

See all River Cruises that depart from St Louis

Click on a cruise ship itinerary sailing from St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.


American Melody Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2021 Sails: Oct 29, 2022: Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Sep 30, Oct 14, Oct 28, More...
American Duchess Cruises8 Night - Quilting the Fabric of America River Cruise from St. Louis to Memphis
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Columbus, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2022 Sails: Jun 11, More...
American Duchess Cruises8 Night - St. Louis to Memphis
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2022 Sails: Jun 11, More...
American Countess Cruises8 Night - St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2022 Sails: Jul 11, Jul 25, Sep 19, 2023: Jul 17, Aug 28, More...
American Duchess Cruises8 Night - St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2022 Sails: Jul 23, Sep 3, Sep 17, 2023: Aug 12, Aug 26, Sep 9, More...
American Queen Cruises8 Night - American Culinary Experience Cruise from St. Louis to Louisville
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2022 Sails: Jul 24, More...
Queen of the Mississippi Cruises10 Night - Ohio River Cruise from St. Louis to Pittsburgh, PA
Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2022 Sails: Aug 6, Aug 26, Sep 15, 2023: Aug 5, Aug 25, Sep 14, More...
American Duchess Cruises8 Night - An American Music Festival River Cruise from St. Louis (Alton) to Nashville (Clarksville)
Starting in St. Louis, MO; with stops in Alton, IL; St. Louis, MO; Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Aug 6, More...
American Countess Cruises8 Night - St. Louis (Alton) to Chicago (Ottawa)
Starting in St. Louis (Alton); with stops in Alton, IL; Hannibal, MO; Grafton, IL; Havana, IL; Peoria, IL; Ottawa, IL
2022 Sails: Aug 8, More...
American Queen Cruises8 Night - St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2022 Sails: Aug 21, Sep 4, Oct 9, 2023: Jul 16, Jul 30, Sep 24, More...


St Louis Cruise Departures

Connecting cruisers with the best cruise prices on discount cruises since 2003. Privacy Policy

Cruise news from Cruise Compete, where you compare cruise prices to get the best cruise discounts and deals
Let our Virtual Cruise Advisor(TM) recommend the best cruises for you.