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St Louis River Cruises

River Cruises that visit North America: United States: Missouri: St Louis

River Cruises that depart from St Louis

See all Cruises that visit St Louis

Mississippi River Cruises

Click on a cruise ship itinerary that visits St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Duchess Cruises8 Night - Special Edition Voyages - Special Events - Founders Cruise from Louisville to St. Louis, MO (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: May 2, More...
American Duchess Cruises8 Night - Upper Mississippi River - Midwestern Passage Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: May 2, Jul 4, Sep 26, More...
American Duchess Cruises8 Night - Special Edition Voyages - Culinary & Cocktails - American Culinary Experience Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 4, More...
America Cruises10 Night - Mississippi River Gateway Cruise from New Orleans, LA to St. Louis, MO
Starting in New Orleans, LA; with stops in Baton Rouge, LA; Natchez, MS; Vicksburg, MS; Memphis, TN; New Madrid, MO; Paducah, KY; St. Louis, MO
2021 Sails: Jul 11, Aug 25, 2022: Jul 10, Aug 24, 2023: Jul 9, Aug 23, More...
American Queen Cruises8 Night - Special Edition Voyages - Special Events - Founders Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 11, More...
American Queen Cruises8 Night - Upper Mississippi River - Midwestern Passage Cruise from Louisville to St. Louis (Alton)
Starting in Louisville, KY; with stops in Brandenburg, KY; Owensboro, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO (Alton)
2021 Sails: Jul 11, More...
Queen of the Mississippi Cruises10 Night - Mississippi River Gateway Cruise from New Orleans, LA to St. Louis, MO
Starting in New Orleans, LA; with stops in Baton Rouge, LA; Natchez, MS; Vicksburg, MS; Memphis, TN; New Madrid, MO; Paducah, KY; St. Louis, MO
2021 Sails: Jul 17, 2022: Jul 27, 2023: Jul 26, More...
American Queen Cruises15 Night - Mississippi River - The Mighty Mississippi Cruise from Minneapolis (Red Wing) to New Orleans
Starting in Minneapolis, MN; with stops in Red Wing, MN; Winona, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Nottoway; New Orleans, LA
2021 Sails: Jul 25, 2022: Sep 11, 2023: Oct 1, More...
America Cruises7 Night - Upper Mississippi River Cruise from St. Paul, MN to St. Louis, MO
Starting in St. Paul, MN; with stops in Red Wing, MN; Winona, MN; Dubuque, IA; Davenport, IA; Fort Madison, IA; Hannibal, MO; St. Louis, MO
2021 Sails: Jul 28, Sep 11, Sep 25, Oct 9, 2022: Jul 27, Sep 10, Sep 24, Oct 8, 2023: Jul 26, More...
American Duchess Cruises15 Night - Mississippi River - The Mighty Mississippi Cruise from Minneapolis (Red Wing) to New Orleans
Starting in Minneapolis, MN; with stops in Red Wing, MN; Winona, MN; La Crosse, WI; Dubuque, IA; Bettendorf, IA; Burlington, IA; Hannibal, MO; St. Louis, MO; Memphis, TN; Port of the Mississippi Delta; Vicksburg, MS; Natchez, MS; Nottoway; New Orleans, LA
2021 Sails: Aug 1, 2022: Sep 24, 2023: Sep 16, More...


St Louis River Cruises

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