St Louis River Cruises
River Cruises that visit North America: United States: Missouri: St Louis
River Cruises that depart from St Louis
See all Cruises that visit St Louis
Mississippi River Cruises
River cruises by river name
8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, 2027: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 30, Jul 14, Jul 28, Aug 11, More...
15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...8 Night - Upper Mississippi River Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 25, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, 2028: Jun 23, Jul 8, Jul 21, Aug 4, Aug 19, Sep 1, Sep 15, More...15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Oct 16, 2027: Oct 15, 2028: Sep 29, More...22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2027 Sails: Jun 4, 2028: Jun 2, More...22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2027 Sails: Jun 11, 2028: Jun 9, More...
21 Night - Mississippi River Odyssey
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, St Louis, Missouri (Alton), Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2027 Sails: Jul 6, More...
River Cruises that visit North America: United States: Missouri: St Louis
River Cruises that depart from St Louis
See all Cruises that visit St Louis
Mississippi River Cruises
Click on a cruise ship itinerary that visits St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
8 Night - Upper Mississippi River CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, 2027: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, 2028: Jun 30, Jul 14, Jul 28, Aug 11, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...
15 Night - Grand Ohio River CruiseStarting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, More...
8 Night - Upper Mississippi River CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Day of River Cruising, Dubuque, IA, Davenport, IA, Hannibal, MO, St Louis, MO / Alton, IL, Alton, IL / St Louis, MO
2026 Sails: Aug 21, Sep 4, Sep 18, Oct 2, 2027: Jun 25, Aug 6, Aug 20, Sep 3, Sep 17, Oct 1, 2028: Jun 23, Jul 8, Jul 21, Aug 4, Aug 19, Sep 1, Sep 15, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 11, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Sep 25, 2027: Sep 24, 2028: Aug 25, More...
15 Night - Grand Heartland CruiseStarting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
2026 Sails: Oct 16, 2027: Oct 15, 2028: Sep 29, More...
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2027 Sails: Jun 4, 2028: Jun 2, More...
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Day of Cruising, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2027 Sails: Jun 11, 2028: Jun 9, More...
21 Night - Mississippi River OdysseyStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, St Louis, Missouri (Alton), Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2027 Sails: Jul 6, More...
