Pittsburgh Cruise Departures

Cruises that depart from North America: United States: Pennsylvania: Pittsburgh

Cruises that visit Pittsburgh

See all River Cruises that depart from Pittsburgh

Click on a cruise ship itinerary sailing from Pittsburgh (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pittsburgh), please visit: Cruise Search or try our Virtual Cruise Advisor™.

8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 3, Jul 17, 2027: Jul 2, Jul 16, Jul 30, 2028: Jul 15, Jul 29, More...

American Cruise Lines, American Heritage

8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
2026 Sails: Jul 10, Jul 24, Aug 7, 2027: Jul 16, Jul 30, Aug 13, 2028: Jul 15, Jul 29, Aug 12, More...

American Cruise Lines, American Melody

15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Aug 13, 2028: Aug 12, More...

American Cruise Lines, American Heritage

15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Aug 21, 2027: Aug 27, 2028: Aug 26, More...

American Cruise Lines, American Symphony

Pittsburgh Cruise Departures