Pittsburgh River Cruises

River Cruises that visit North America: United States: Pennsylvania: Pittsburgh

River Cruises that depart from Pittsburgh

See all Cruises that visit Pittsburgh

Ohio River Cruises

Click on a cruise ship itinerary that visits Pittsburgh (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Pittsburgh), please visit: Cruise Search or try our Virtual Cruise Advisor™.

15 Night - Grand Ohio River Cruise
Starting in St Louis, MO, Cruising the Mississippi River, Paducah, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Louisville, KY, Madison, IN, Cincinnati, OH, Day of Cruising, Maysville, KY, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jun 19, 2027: Jul 2, More...

American Cruise Lines, American Heritage

8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2026 Sails: Jul 2, Jul 17, Jul 31, Aug 14, More...

American Cruise Lines, American Melody

15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
2026 Sails: Jul 31, 2027: Jul 16, More...

American Cruise Lines, American Heritage

American Cruise Lines, American Symphony

8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
2027 Sails: Jul 18, Aug 3, Aug 19, 2028: Jul 16, Aug 2, Aug 18, Sep 3, Sep 19, More...

American Cruise Lines, American Symphony