New Orleans River Cruise Departures
River Cruises that depart from North America: United States: Louisiana: New Orleans
River Cruises that visit New Orleans
See all Cruises that depart from New Orleans
Mississippi River Cruises
River cruises by river name
7 Night - Historic Mississippi River Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 25, More...
7 Night - Historic Mississippi River Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 28, Apr 3, Apr 9, Apr 15, Apr 21, Apr 27, May 3, May 9, May 15, May 21, May 27, Jun 16, Oct 12, Oct 18, Oct 24, Oct 30, Nov 5, Nov 11, Nov 17, Nov 23, Nov 29, 2027: Mar 27, Apr 2, Apr 8, More...
8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Apr 24, May 8, Oct 30, Nov 13, Nov 28, 2027: Mar 26, Apr 9, Apr 23, May 7, Oct 29, Nov 12, Dec 21, 2028: Apr 8, Apr 22, May 6, May 20, Oct 28, Nov 11, Nov 25, More...22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: May 22, 2027: May 21, 2028: Jun 3, More...8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Jun 2, Sep 25, 2027: Jun 1, Jun 15, Oct 1, 2028: May 31, Jun 14, Sep 30, More...
22 Night - Complete Mississippi River Cruise
Starting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 10, More...
14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, More...11 Night - Mississippi River Gateway Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA / Houmas House, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, 2027: Jun 29, 2028: Jun 28, More...21 Night - Mississippi River Odyssey
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Jul 18, More...14 Night - The Big Easy to the Gateway City
Starting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jul 18, More...
River Cruises that depart from North America: United States: Louisiana: New Orleans
River Cruises that visit New Orleans
See all Cruises that depart from New Orleans
Mississippi River Cruises
Click on a cruise ship itinerary sailing from New Orleans (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just New Orleans), please visit: Cruise Search or try our Virtual Cruise Advisor™.
River cruises by river name
7 Night - Historic Mississippi River CruiseStarting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 25, More...
7 Night - Historic Mississippi River CruiseStarting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA / Houmas House, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
2026 Sails: Mar 28, Apr 3, Apr 9, Apr 15, Apr 21, Apr 27, May 3, May 9, May 15, May 21, May 27, Jun 16, Oct 12, Oct 18, Oct 24, Oct 30, Nov 5, Nov 11, Nov 17, Nov 23, Nov 29, 2027: Mar 27, Apr 2, Apr 8, More...
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Apr 24, May 8, Oct 30, Nov 13, Nov 28, 2027: Mar 26, Apr 9, Apr 23, May 7, Oct 29, Nov 12, Dec 21, 2028: Apr 8, Apr 22, May 6, May 20, Oct 28, Nov 11, Nov 25, More...
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: May 22, 2027: May 21, 2028: Jun 3, More...
8 Night - Lower Mississippi River CruiseStarting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA / Houmas House, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
2026 Sails: Jun 2, Sep 25, 2027: Jun 1, Jun 15, Oct 1, 2028: May 31, Jun 14, Sep 30, More...
22 Night - Complete Mississippi River CruiseStarting in New Orleans, La, Day of River Cruising, Oak Alley, LA, Houmas House, LA, Baton Rouge, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Greenville, MS, Tunica, MS, Memphis, TN, Cape Girardeau, MO, Day of River Cruising, St Louis, MO, Day of River Cruising, Hannibal, MO, Day of River Cruising, Muscatine, IA, Dubuque, IA, Day of River Cruising, Winona, MN, Red Wing, MN, St Paul, MN
2026 Sails: Jun 12, 2027: Jun 11, 2028: Jun 10, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jun 13, More...
11 Night - Mississippi River Gateway CruiseStarting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA / Houmas House, LA, Day of River Cruising, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of River Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
2026 Sails: Jun 22, 2027: Jun 29, 2028: Jun 28, More...
21 Night - Mississippi River OdysseyStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois, Hannibal, Missouri, Burlington, Iowa, Quad Cities, Iowa, Dubuque, Iowa, La Crosse, Wisconsin, Red Wing, Minnesota, St Paul, Minnesota
2026 Sails: Jul 18, More...
14 Night - The Big Easy to the Gateway CityStarting in New Orleans, Louisiana, Darrow, Louisiana, St Francisville, Louisiana, Natchez, Mississippi, Vicksburg, Mississippi, Greenville, Mississippi, Scenic Sailing Lower Mississippi, Memphis, Tennessee, Scenic Sailing Upper Mississippi, Paducah, Kentucky, Cape Girardeau, Missouri, St Louis, Missouri, Alton, Illinois
2026 Sails: Jul 18, More...
