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New Orleans River Cruise Departures

River Cruises that depart from North America: United States: Louisiana: New Orleans

River Cruises that visit New Orleans

See all Cruises that depart from New Orleans

Mississippi River Cruises

Click on a cruise ship itinerary sailing from New Orleans (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just New Orleans), please visit: Cruise Search or try our Virtual Cruise Advisor™.

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America Cruises7 Night - Mississippi River Cruise Roundtrip from New Orleans, LA
Starting in New Orleans, LA; with stops in Oak Alley, LA; Natchez, MS; Vicksburg, MS; St. Francisville, LA; Baton Rouge, LA; Houmas House, LA; New Orleans, LA
2021 Sails: Apr 20, Apr 27, May 4, May 11, May 18, May 25, Jun 1, Jun 8, Jun 15, Jun 22, Nov 6, Nov 21, 2022: Feb 20, Feb 27, Mar 6, Mar 13, Apr 5, Apr 12, Apr 19, Apr 26, May 3, May 10, May 17, May 24, More...
Queen of the Mississippi Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Valley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis TN
2021 Sails: Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Nov 13, Nov 27, 2022: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, Jun 4, Jun 18, Jul 2, Oct 15, Oct 29, Nov 12, Nov 26, 2023: Feb 11, Feb 25, More...
American Countess Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: May 1, May 15, Jun 26, Jul 10, Jul 24, Aug 7, Sep 11, Oct 23, 2022: Mar 14, Mar 28, Apr 11, Oct 10, Nov 14, 2023: Mar 20, Apr 3, Apr 17, Sep 18, Nov 6, More...
American Jazz Cruises7 Night - Lower Mississippi River Cruise from New Orleans, LA to Memphis, TN
Starting in New Orleans, LA; with stops in Oak Alley, LA; Baton Rouge, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Memphis, TN
2021 Sails: May 2, May 16, May 30, Jun 13, Jun 27, Oct 10, Oct 24, Nov 7, Nov 21, Dec 5, Dec 20, 2022: Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Jun 12, Jun 26, Oct 9, Oct 23, 2023: Feb 19, More...
American Queen Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: May 16, May 30, Jun 13, Aug 8, Sep 5, Sep 19, Oct 3, Oct 17, Nov 14, 2022: Mar 20, Apr 3, Apr 17, May 1, May 15, May 29, Sep 25, 2023: Feb 12, Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, May 21, More...
American Duchess Cruises8 Night - Lower Mississippi River - Charms of the South Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: May 23, Aug 15, Sep 12, Oct 31, Nov 28, 2022: Mar 19, Apr 2, Apr 16, Apr 30, Jun 25, Oct 8, Dec 31, 2023: Mar 11, Mar 25, Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Sep 30, Nov 11, Nov 25, Dec 9, More...
American Countess Cruises8 Night - Special Edition Voyages - Holidays - Salute to Veterans Cruise from New Orleans to Memphis
Starting in New Orleans, LA; with stops in Nottoway; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Port of the Mississippi Delta; Memphis, TN
2021 Sails: May 29, More...
America Cruises4 Night - Highlights of the Mississippi River Cruise Roundtrip from New Orleans, LA
Starting in New Orleans, LA; with stops in Houmas House, LA; Baton Rouge, LA; Oak Alley, LA; New Orleans, LA
2021 Sails: Jun 29, Jul 3, Jul 7, Nov 13, Nov 17, 2022: Mar 20, Mar 24, Mar 28, Apr 1, Jun 28, Jul 2, Jul 6, Nov 12, Nov 16, 2023: Mar 19, Mar 23, Mar 27, Mar 31, Jun 27, Jul 1, Jul 5, More...
America Cruises10 Night - Mississippi River Gateway Cruise from New Orleans, LA to St. Louis, MO
Starting in New Orleans, LA; with stops in Baton Rouge, LA; Natchez, MS; Vicksburg, MS; Memphis, TN; New Madrid, MO; Paducah, KY; St. Louis, MO
2021 Sails: Jul 11, Aug 25, 2022: Jul 10, Aug 24, 2023: Jul 9, Aug 23, More...
Queen of the Mississippi Cruises10 Night - Mississippi River Gateway Cruise from New Orleans, LA to St. Louis, MO
Starting in New Orleans, LA; with stops in Baton Rouge, LA; Natchez, MS; Vicksburg, MS; Memphis, TN; New Madrid, MO; Paducah, KY; St. Louis, MO
2021 Sails: Jul 17, 2022: Jul 27, 2023: Jul 26, More...


New Orleans River Cruise Departures

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