Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
16 Night - Machu Picchu & Mayan Ruins
Starting in Lima (Callao), Salaverry, Cruising the Pacific Ocean, Guayaquil, Manta, Cruising the Pacific Ocean, Golfito, Panama City, Panama Canal Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Harvest Caye, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2027 Sails: Mar 10, More...
10 Night - Panama & Pristine Isles
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Port Antonio, Great Stirrup Cay, Miami
2027 Sails: Mar 15, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Ensenada, Mexico, Los Angeles, California
2027 Sails: Mar 18, More...
17 Night - Panama & Scenic South America
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Cozumel, Mexico, Scenic Sailing Gulf of Mexico, Fort Lauderdale, Florida
2027 Sails: Mar 22, More...
14 Night - Carnival of Caribbean Colors
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Bonaire (Kralendijk), Cruising the Caribbean Sea, St Georges, Castries, Gustavia, Tortola, Cruising the Atlantic Ocean, Cruising the Bahamian Waters, Miami
2027 Sails: Mar 31, More...
19 Night - Panama Canal & the Americas
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2027 Sails: Apr 1, 2028: Apr 8, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Mazatlan, Mexico, Cabo San Lucas, Mexico, Los Angeles, California
2027 Sails: Apr 3, More...
11 Night - Pristine Islands of the Caribbean & the Panama Canal
Starting in Panama City, Panama, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Apr 3, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2027 Sails: Apr 4, More...
17 Night - A Grand Journey Through Balmy Shores & Enchanting Nature to Panama's Wonders
Starting in San Juan, Gustavia, Little Bay, Basseterre, Key West, Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador)
2027 Sails: Apr 5, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
16 Night - Machu Picchu & Mayan RuinsStarting in Lima (Callao), Salaverry, Cruising the Pacific Ocean, Guayaquil, Manta, Cruising the Pacific Ocean, Golfito, Panama City, Panama Canal Transit, Puerto Limon, Cruising the Caribbean Sea, Roatan, Harvest Caye, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2027 Sails: Mar 10, More...
Deal link -> Special
10 Night - Panama & Pristine IslesStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Port Antonio, Great Stirrup Cay, Miami
2027 Sails: Mar 15, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Ensenada, Mexico, Los Angeles, California
2027 Sails: Mar 18, More...
17 Night - Panama & Scenic South AmericaStarting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Cozumel, Mexico, Scenic Sailing Gulf of Mexico, Fort Lauderdale, Florida
2027 Sails: Mar 22, More...
14 Night - Carnival of Caribbean ColorsStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Bonaire (Kralendijk), Cruising the Caribbean Sea, St Georges, Castries, Gustavia, Tortola, Cruising the Atlantic Ocean, Cruising the Bahamian Waters, Miami
2027 Sails: Mar 31, More...
19 Night - Panama Canal & the AmericasStarting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2027 Sails: Apr 1, 2028: Apr 8, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Mazatlan, Mexico, Cabo San Lucas, Mexico, Los Angeles, California
2027 Sails: Apr 3, More...
11 Night - Pristine Islands of the Caribbean & the Panama CanalStarting in Panama City, Panama, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Apr 3, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2027 Sails: Apr 4, More...
17 Night - A Grand Journey Through Balmy Shores & Enchanting Nature to Panama's WondersStarting in San Juan, Gustavia, Little Bay, Basseterre, Key West, Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador)
2027 Sails: Apr 5, More...
