Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
11 Night - Pristine Islands of the Caribbean & the Panama Canal
Starting in Panama City, Panama, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Apr 3, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2027 Sails: Apr 4, More...
17 Night - A Grand Journey Through Balmy Shores & Enchanting Nature to Panama's Wonders
Starting in San Juan, Gustavia, Little Bay, Basseterre, Key West, Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador)
2027 Sails: Apr 5, More...10 Night - A Journey Through Enchanting Nature & the Marvels of the Panama Canal
Starting in Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador)
2027 Sails: Apr 12, More...21 Night - An Extended Journey from Majestic Horizons to Mayan Gems
Starting in Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles
2027 Sails: Apr 12, More...
32 Night - The Americas & Caribbean
Starting in Vancouver, Victoria CA, Canada, Astoria, San Francisco, Santa Catalina Island, San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 2, More...25 Night - The Americas & Caribbean
Starting in San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 9, More...14 Night - The Americas & Caribbean
Starting in Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 20, More...
80 Night - Arctic to Antarctic Explorer
Starting in Nuuk, Itilleq Fjord, Ilulissat, Uummannaq, Sail Baffin Bay, Pond Inlet, Canadian High Arctic, Sail Baffin Bay, Sisimiut, Nuuk, Kapisillit, Paamiut, Ivittuut, Sail the Labrador Sea, Battle Harbour, Newfoundland, Labrador, Red Bay, Newfoundland, Labrador, Woody Point (Bonne Bay), Newfoundland, Havre-Saint-Pierre, Quebec, Tadoussac, Quebec, Quebec City, Quebec, Trois-Rivieres, Quebec, Scenic Sailing St Lawrence Seaway Locks, Toronto, Ontario, Scenic Sailing St Lawrence Seaway Locks, Trois-Rivieres, Quebec, Quebec City, Quebec, Tadoussac, Quebec, Havre-Saint-Pierre, Quebec, Woody Point (Bonne Bay), Newfoundland, Sydney NS, Nova Scotia, Halifax, Nova Scotia, Sail the Atlantic Ocean, New York City, New York, Sail the Atlantic Ocean, San Salvador Island, Man of War Bay (Great Inagua), Port Antonio, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso), Sail the Pacific Ocean, Scenic Sailing Chilean Fjords, Puerto Chacabuco, Scenic Sailing Chilean Fjords, Chilean Glaciers, Scenic Sailing Chilean Fjords, Punta Arenas, Chilean Glaciers, Garibaldi Fjord, Scenic Sailing Cape Horn, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing Cape Horn, Ushuaia
2027 Sails: Sep 9, More...
23 Night - Panama Canal & Pacific Coast
Starting in Vancouver, Canada, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, New York City (Manhattan or Brooklyn), New York
2027 Sails: Sep 22, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
11 Night - Pristine Islands of the Caribbean & the Panama CanalStarting in Panama City, Panama, Panama City / Panama Canal Transit, San Blas Islands, Lemon Cay, Panama, Cartagena CO, Cabo de La Vela, Colombia, Willemstad AN, Curacao, Tobago Cays, Grenadines, Mayreau, Grenadines, Soufriere, St Lucia, Bridgetown, Barbados
2027 Sails: Apr 3, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2027 Sails: Apr 4, More...
17 Night - A Grand Journey Through Balmy Shores & Enchanting Nature to Panama's WondersStarting in San Juan, Gustavia, Little Bay, Basseterre, Key West, Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador)
2027 Sails: Apr 5, More...
10 Night - A Journey Through Enchanting Nature & the Marvels of the Panama CanalStarting in Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador)
2027 Sails: Apr 12, More...
21 Night - An Extended Journey from Majestic Horizons to Mayan GemsStarting in Miami, Ocho Rios, Jamaica, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, Crossing the Panama Canal, Panama City (Amador), Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa Maria Huatulco), Puerto Vallarta, Los Angeles
2027 Sails: Apr 12, More...
32 Night - The Americas & CaribbeanStarting in Vancouver, Victoria CA, Canada, Astoria, San Francisco, Santa Catalina Island, San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 2, More...
25 Night - The Americas & CaribbeanStarting in San Diego, Puerto Vallarta, Manzanillo, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 9, More...
14 Night - The Americas & CaribbeanStarting in Fuerte Amador (Panama City), Panama Canal Transit, Cartagena CO, Port Antonio, Montego Bay, George Town (Grand Cayman), Miami, Port Canaveral, Norfolk, New York
2027 Sails: Aug 20, More...
80 Night - Arctic to Antarctic ExplorerStarting in Nuuk, Itilleq Fjord, Ilulissat, Uummannaq, Sail Baffin Bay, Pond Inlet, Canadian High Arctic, Sail Baffin Bay, Sisimiut, Nuuk, Kapisillit, Paamiut, Ivittuut, Sail the Labrador Sea, Battle Harbour, Newfoundland, Labrador, Red Bay, Newfoundland, Labrador, Woody Point (Bonne Bay), Newfoundland, Havre-Saint-Pierre, Quebec, Tadoussac, Quebec, Quebec City, Quebec, Trois-Rivieres, Quebec, Scenic Sailing St Lawrence Seaway Locks, Toronto, Ontario, Scenic Sailing St Lawrence Seaway Locks, Trois-Rivieres, Quebec, Quebec City, Quebec, Tadoussac, Quebec, Havre-Saint-Pierre, Quebec, Woody Point (Bonne Bay), Newfoundland, Sydney NS, Nova Scotia, Halifax, Nova Scotia, Sail the Atlantic Ocean, New York City, New York, Sail the Atlantic Ocean, San Salvador Island, Man of War Bay (Great Inagua), Port Antonio, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso), Sail the Pacific Ocean, Scenic Sailing Chilean Fjords, Puerto Chacabuco, Scenic Sailing Chilean Fjords, Chilean Glaciers, Scenic Sailing Chilean Fjords, Punta Arenas, Chilean Glaciers, Garibaldi Fjord, Scenic Sailing Cape Horn, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing Cape Horn, Ushuaia
2027 Sails: Sep 9, More...
23 Night - Panama Canal & Pacific CoastStarting in Vancouver, Canada, San Diego, California, Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, New York City (Manhattan or Brooklyn), New York
2027 Sails: Sep 22, More...
