Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
40 Night - The Americas & Antarctic Explorer
Starting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso), Sail the Pacific Ocean, Scenic Sailing Chilean Fjords, Puerto Chacabuco, Scenic Sailing Chilean Fjords, Chilean Glaciers, Scenic Sailing Chilean Fjords, Punta Arenas, Chilean Glaciers, Garibaldi Fjord, Scenic Sailing Cape Horn, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing Cape Horn, Ushuaia
2026 Sails: Nov 6, More...17 Night - Panama & Scenic South America
Starting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Nov 6, More...
19 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Nov 23, More...28 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera, Playa Flamingo, Acajutla, Zihuatanejo, Manzanillo, Puerto Vallarta, San Diego
2026 Sails: Nov 23, More...10 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Dec 2, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Dec 12, 2027: Feb 14, Apr 19, More...
90 Night - South America Discovery
Starting in Hamburg, Germany, Rotterdam, Netherlands, Zeebrugge (tours to Bruges), Belgium, Southampton, England, UK, Hamilton, Bermuda, Port Canaveral, FL, Fort Lauderdale, FL, Grand Turk, Turks and Caicos Islands, Bridgetown, Barbados, Fortaleza, Brazil, Salvador, Brazil, Buzios, Brazil, Rio De Janeiro, Brazil, Santos (tours to Sao Paulo), Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Puerto Madryn, Argentina, Ushuaia, Argentina, Cape Horn, Chile (Sail by), Punta Arenas, Chile, Amalia Glacier, Chile (Scenic Cruising), PIO X Glacier, Chile (Scenic Cruising), Puerto Montt, Chile, San Antonio CL (tours to Santiago), Chile, Coquimbo, Chile, Arica, Chile, Callao (tours to Lima), Peru, Manta, Ecuador, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Oranjestad, Aruba, Fort Lauderdale, FL, Port Canaveral, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK, Zeebrugge (tours to Bruges), Belgium, Hamburg, Germany
2027 Sails: Jan 5, More...
20 Night - Panama Canal & Caribbean
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 5, More...10 Night - Panama Potpourri
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2027 Sails: Jan 5, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
40 Night - The Americas & Antarctic ExplorerStarting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso), Sail the Pacific Ocean, Scenic Sailing Chilean Fjords, Puerto Chacabuco, Scenic Sailing Chilean Fjords, Chilean Glaciers, Scenic Sailing Chilean Fjords, Punta Arenas, Chilean Glaciers, Garibaldi Fjord, Scenic Sailing Cape Horn, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing Cape Horn, Ushuaia
2026 Sails: Nov 6, More...
17 Night - Panama & Scenic South AmericaStarting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Nov 6, More...
19 Night - The Americas & CaribbeanStarting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Nov 23, More...
28 Night - The Americas & CaribbeanStarting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera, Playa Flamingo, Acajutla, Zihuatanejo, Manzanillo, Puerto Vallarta, San Diego
2026 Sails: Nov 23, More...
10 Night - The Americas & CaribbeanStarting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Dec 2, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Dec 12, 2027: Feb 14, Apr 19, More...
90 Night - South America DiscoveryStarting in Hamburg, Germany, Rotterdam, Netherlands, Zeebrugge (tours to Bruges), Belgium, Southampton, England, UK, Hamilton, Bermuda, Port Canaveral, FL, Fort Lauderdale, FL, Grand Turk, Turks and Caicos Islands, Bridgetown, Barbados, Fortaleza, Brazil, Salvador, Brazil, Buzios, Brazil, Rio De Janeiro, Brazil, Santos (tours to Sao Paulo), Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Puerto Madryn, Argentina, Ushuaia, Argentina, Cape Horn, Chile (Sail by), Punta Arenas, Chile, Amalia Glacier, Chile (Scenic Cruising), PIO X Glacier, Chile (Scenic Cruising), Puerto Montt, Chile, San Antonio CL (tours to Santiago), Chile, Coquimbo, Chile, Arica, Chile, Callao (tours to Lima), Peru, Manta, Ecuador, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Oranjestad, Aruba, Fort Lauderdale, FL, Port Canaveral, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK, Zeebrugge (tours to Bruges), Belgium, Hamburg, Germany
2027 Sails: Jan 5, More...
20 Night - Panama Canal & CaribbeanStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 5, More...
10 Night - Panama PotpourriStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2027 Sails: Jan 5, More...
