Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
21 Night - Ultimate America's Historic Journey to Panama
Starting in New York, Wilmington, Delaware / Chesapeake and Delaware Canal, Baltimore, Maryland, Yorktown, Virginia, Wilmington, North Carolina, Charleston, South Carolina, Miami, Florida, Key West, Florida, Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 5, More...
16 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Ocho Rios, Jamaica, Miami, Fl
2026 Sails: Oct 7, More...
16 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Falmouth, Jamaica, Miami, Fl
2026 Sails: Oct 13, More...19 Night - Repo - Panama Canal
Starting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Falmouth, Jamaica, Miami, Fl, New York City, Ny
2026 Sails: Oct 13, More...10 Night - Pristine Islands of the Bahamas & the Panama Canal
Starting in Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 16, More...
19 Night - Panama Canal & the Americas
Starting in New York City, New York, Sail the Atlantic Ocean, San Salvador Island, Man of War Bay (Great Inagua), Port Antonio, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Oct 25, More...
17 Night - Panama Canal : La to Miami Halloween
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama City, Panama, Panama Canal (Cruising), Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 29, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Nov 6, More...
17 Night - Panama & Scenic South America
Starting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Nov 6, More...
19 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Nov 23, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
21 Night - Ultimate America's Historic Journey to PanamaStarting in New York, Wilmington, Delaware / Chesapeake and Delaware Canal, Baltimore, Maryland, Yorktown, Virginia, Wilmington, North Carolina, Charleston, South Carolina, Miami, Florida, Key West, Florida, Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 5, More...
16 Night - Repo - Panama CanalStarting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Ocho Rios, Jamaica, Miami, Fl
2026 Sails: Oct 7, More...
Deal link -> Special
16 Night - Repo - Panama CanalStarting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Falmouth, Jamaica, Miami, Fl
2026 Sails: Oct 13, More...
Deal link -> Special
19 Night - Repo - Panama CanalStarting in Los Angeles, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera / Puntarenas, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Falmouth, Jamaica, Miami, Fl, New York City, Ny
2026 Sails: Oct 13, More...
10 Night - Pristine Islands of the Bahamas & the Panama CanalStarting in Nassau, Bahamas, Staniel Cay, Bahamas, San Salvador Island, Bahamas, Cabo de La Vela, Colombia, Cartagena CO, San Blas, Panama, Bocas Del Toro, Panama, Panama Canal Transit / Panama City, Panama, Panama City, Panama
2026 Sails: Oct 16, More...
19 Night - Panama Canal & the AmericasStarting in New York City, New York, Sail the Atlantic Ocean, San Salvador Island, Man of War Bay (Great Inagua), Port Antonio, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Oct 25, More...
17 Night - Panama Canal : La to Miami HalloweenStarting in Los Angeles, California, Cabo San Lucas, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama City, Panama, Panama Canal (Cruising), Panama, Cartagena CO, Miami, Florida
2026 Sails: Oct 29, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Nov 6, More...
17 Night - Panama & Scenic South AmericaStarting in Fort Lauderdale, Florida, Scenic Sailing Gulf of Mexico, Cozumel, Mexico, Sail the Caribbean Sea, Scenic Sailing Panama Canal, Panama City (Fuerte Amador), Sail the Pacific Ocean, Manta, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Santiago (Valparaiso)
2026 Sails: Nov 6, More...
19 Night - The Americas & CaribbeanStarting in Fort Lauderdale, Nassau (Paradise Island), Samana, San Juan, Jost Van Dyke, British Virgin Islands, Oranjestad, Aruba, Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puerto Caldera
2026 Sails: Nov 23, More...
