Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Feb 25, Dec 12, 2027: Feb 14, Apr 19, More...
12 Night - Panama Canal - Miami
Starting in Miami, Fl, Santa Marta, Colombia, Cartagena CO, Transit Panama Canal / At Sea, Panama City, Panama, Manta, Ecuador, Salaverry / Trujillo, Peru, Callao / Lima, Peru
2026 Sails: Feb 27, More...
13 Night - Chile & Peru Cruise : Coquimbo, Pisco & Lima
Starting in San Antonio Cl, Coquimbo, Iquique, Arica, Pisco, Callao (Lima), Panama City (Fuerte Amador)
2026 Sails: Mar 2, More...17 Night - Repo - Panama Canal
Starting in Callao / Lima, Peru, Salaverry / Trujillo, Peru, Manta, Ecuador, Panama City, Panama, Puntarenas / Puerto Caldera, Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Acapulco, Mexico, Manzanillo, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Mar 11, More...
19 Night - Panama Canal & the Americas
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2026 Sails: Mar 17, More...
20 Night - Panama Canal Connoisseur
Starting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Mar 25, More...10 Night - Palms & Panama Canal
Starting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City
2026 Sails: Mar 25, More...
19 Night - Treasures of French Polynesia & the Marquesas Islands
Starting in Papeete, Opunohu Bay, Moorea, Rangiroa, Tuamotus, Taiohae, Nuku Hiva Island, French Polynesia, Atuona, Hiva Oa Island, French Polynesia, Cocos Island, Costa Rica, Panama City, Panama
2026 Sails: Mar 25, More...
19 Night - Panama Canal & the Americas
Starting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2026 Sails: Mar 26, More...
27 Night - Panama Canal and Caribbean Adventurer
Starting in San Juan, Puerto Rico, St Thomas, US Virgin Islands, St Kitts, Aruba, Curacao, Bonaire, Caribbean Netherlands, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 5, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Feb 25, Dec 12, 2027: Feb 14, Apr 19, More...
12 Night - Panama Canal - MiamiStarting in Miami, Fl, Santa Marta, Colombia, Cartagena CO, Transit Panama Canal / At Sea, Panama City, Panama, Manta, Ecuador, Salaverry / Trujillo, Peru, Callao / Lima, Peru
2026 Sails: Feb 27, More...
Deal link -> Special
13 Night - Chile & Peru Cruise : Coquimbo, Pisco & LimaStarting in San Antonio Cl, Coquimbo, Iquique, Arica, Pisco, Callao (Lima), Panama City (Fuerte Amador)
2026 Sails: Mar 2, More...
17 Night - Repo - Panama CanalStarting in Callao / Lima, Peru, Salaverry / Trujillo, Peru, Manta, Ecuador, Panama City, Panama, Puntarenas / Puerto Caldera, Costa Rica, Acajutla, El Salvador, Puerto Quetzal, Guatemala, Huatulco, Mexico, Acapulco, Mexico, Manzanillo, Mexico, Mazatlan, Mexico, Cabo San Lucas, Mexico, San Diego, Ca
2026 Sails: Mar 11, More...
19 Night - Panama Canal & the AmericasStarting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2026 Sails: Mar 17, More...
20 Night - Panama Canal ConnoisseurStarting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Willemstad AN, Oranjestad, Montego Bay, George Town, Miami
2026 Sails: Mar 25, More...
10 Night - Palms & Panama CanalStarting in Tampa, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City
2026 Sails: Mar 25, More...
19 Night - Treasures of French Polynesia & the Marquesas IslandsStarting in Papeete, Opunohu Bay, Moorea, Rangiroa, Tuamotus, Taiohae, Nuku Hiva Island, French Polynesia, Atuona, Hiva Oa Island, French Polynesia, Cocos Island, Costa Rica, Panama City, Panama
2026 Sails: Mar 25, More...
19 Night - Panama Canal & the AmericasStarting in Santiago (Valparaiso), Sail the Pacific Ocean, Iquique, Sail the Pacific Ocean, Lima (Callao), Sail the Pacific Ocean, Panama City (Fuerte Amador), Scenic Sailing Panama Canal, Sail the Caribbean Sea, Port Antonio, Man of War Bay (Great Inagua), San Salvador Island, Sail the Atlantic Ocean, New York City, New York
2026 Sails: Mar 26, More...
27 Night - Panama Canal and Caribbean AdventurerStarting in San Juan, Puerto Rico, St Thomas, US Virgin Islands, St Kitts, Aruba, Curacao, Bonaire, Caribbean Netherlands, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 5, More...
