Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
89 Night - Round World from Marseille
Starting in Marseille, Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU, Newcastle UK, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Busan, Keelung (Taipei), Hong Kong
2026 Sails: Nov 26, More...63 Night - Round World from Barcelona
Starting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU
2026 Sails: Nov 27, More...37 Night - Round World from Barcelona
Starting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco
2026 Sails: Nov 27, More...88 Night - Round World from Barcelona
Starting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU, Newcastle UK, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Busan, Keelung (Taipei), Hong Kong
2026 Sails: Nov 27, More...134 Night - Round World from Barcelona
Starting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU, Newcastle UK, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Busan, Keelung (Taipei), Hong Kong, Nha Trang, Phu My (Ho Chi Minh City), Koh Samui, Singapore, Port Kelang (Kuala Lumpur), Penang, Colombo, Male, Port Louis, Durban, Port Elizabeth ZA, Cape Town, Walvis Bay, Mindelo (Sao Vicente), Las Palmas (Gran Canaria), Barcelona
2026 Sails: Nov 27, More...
10 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puntarenas
2026 Sails: Dec 2, More...8 Night - The Americas & Caribbean
Starting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City)
2026 Sails: Dec 2, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
7 Night - Costa Rica & Panama Canal
Starting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Dec 12, 2027: Feb 14, Apr 19, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
See all River Cruises that visit Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
89 Night - Round World from MarseilleStarting in Marseille, Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU, Newcastle UK, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Busan, Keelung (Taipei), Hong Kong
2026 Sails: Nov 26, More...
63 Night - Round World from BarcelonaStarting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU
2026 Sails: Nov 27, More...
37 Night - Round World from BarcelonaStarting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco
2026 Sails: Nov 27, More...
88 Night - Round World from BarcelonaStarting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU, Newcastle UK, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Busan, Keelung (Taipei), Hong Kong
2026 Sails: Nov 27, More...
134 Night - Round World from BarcelonaStarting in Barcelona, Lisbon, Ponta Delgada (Azores), Praia da Vitoria (Azores), New York, Port Everglades, Half Moon Cay, Panama City, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas, San Diego, Los Angeles, San Francisco, Honolulu, Hilo, Papeete (Tahiti), Suva, Lifou (Loyalty Islands), Noumea, Sydney AU, Newcastle UK, New South Wales, Cairns, Rabaul, Tokyo, Kobe (Kyoto), Nagasaki, Busan, Keelung (Taipei), Hong Kong, Nha Trang, Phu My (Ho Chi Minh City), Koh Samui, Singapore, Port Kelang (Kuala Lumpur), Penang, Colombo, Male, Port Louis, Durban, Port Elizabeth ZA, Cape Town, Walvis Bay, Mindelo (Sao Vicente), Las Palmas (Gran Canaria), Barcelona
2026 Sails: Nov 27, More...
10 Night - The Americas & CaribbeanStarting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City), Puntarenas
2026 Sails: Dec 2, More...
8 Night - The Americas & CaribbeanStarting in Cartagena CO, Willemstad AN, Kralendijk, Oranjestad, Aruba, Santa Marta, Panama Canal Transit, Fuerte Amador (Panama City)
2026 Sails: Dec 2, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
7 Night - Costa Rica & Panama CanalStarting in Colon, Panama Canal Transit, Fuerte Amador, Panama City, Isla Partida, Puerto Jimenez, Golfo Dulce, Quepos, Manuel Antonio National Park, Puerto Caldera, San Jose
2026 Sails: Dec 5, Dec 19, 2027: Jan 2, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Dec 12, 2027: Feb 14, Apr 19, More...
