Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Dec 12, 2027: Feb 14, Apr 19, More...
90 Night - South America Discovery
Starting in Hamburg, Germany, Rotterdam, Netherlands, Zeebrugge (tours to Bruges), Belgium, Southampton, England, UK, Hamilton, Bermuda, Port Canaveral, FL, Fort Lauderdale, FL, Grand Turk, Turks and Caicos Islands, Bridgetown, Barbados, Fortaleza, Brazil, Salvador, Brazil, Buzios, Brazil, Rio De Janeiro, Brazil, Santos (tours to Sao Paulo), Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Puerto Madryn, Argentina, Ushuaia, Argentina, Cape Horn, Chile (Sail by), Punta Arenas, Chile, Amalia Glacier, Chile (Scenic Cruising), PIO X Glacier, Chile (Scenic Cruising), Puerto Montt, Chile, San Antonio CL (tours to Santiago), Chile, Coquimbo, Chile, Arica, Chile, Callao (tours to Lima), Peru, Manta, Ecuador, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Oranjestad, Aruba, Fort Lauderdale, FL, Port Canaveral, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK, Zeebrugge (tours to Bruges), Belgium, Hamburg, Germany
2027 Sails: Jan 5, More...
20 Night - Panama Canal & Caribbean
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 5, More...10 Night - Panama Potpourri
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2027 Sails: Jan 5, More...
23 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Hilo, Hawaii, Kahului, Hawaii, Honolulu, Hawaii
2027 Sails: Jan 6, More...15 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2027 Sails: Jan 6, More...129 Night - Wc Grand Circle Pacific - Ft. Lauderdale to Los Angeles
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Hilo, Hawaii, Kahului, Hawaii, Honolulu, Hawaii, Kauai (Nawiliwili), Hawaii, Pago Pago, American Samoa, Cross International Date Line, Suva, Fiji, Dravuni Island, Fiji, Port Vila, Vanuatu, Luganville, Vanuatu, Rabaul, Papua New Guinea, Alotau (Milne Bay), Papua New Guinea, Cairns, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Auckland, New Zealand, Tauranga, New Zealand, Christchurch (Lyttelton), New Zealand, Dunedin (Port Chalmers), New Zealand, Fiordland National Park (Scenic Cruising), Hobart, Australia, Adelaide, Australia, Perth (Fremantle), Australia, Kimberley Coast (Scenic Cruising), Australia, Darwin, Australia, Bali (Benoa), Indonesia, Lombok, Indonesia, Singapore, Phuket, Thailand, Langkawi, Malaysia, Penang, Malaysia, Kuala Lumpur (Port Kelang), Malaysia, Ho Chi Minh City (Phu My), Vietnam, Cam Ranh (Nha Trang), Vietnam, Halong Bay / Hanoi (Cai Lan), Vietnam, Hong Kong, Taipei (Keelung), Miyakojima, Japan, Kagoshima, Japan, Kochi, Japan, Osaka (for Kyoto), Japan, Tokyo, Japan, Miyako, Japan, Kushiro, Japan, Cross International Date Line, Anchorage (Whittier), Alaska, College Fjord (Scenic Cruising), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Sitka, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada, Los Angeles, California
2027 Sails: Jan 6, More...82 Night - South America Discovery
Starting in Southampton, England, UK, Hamilton, Bermuda, Port Canaveral, FL, Fort Lauderdale, FL, Grand Turk, Turks and Caicos Islands, Bridgetown, Barbados, Fortaleza, Brazil, Salvador, Brazil, Buzios, Brazil, Rio De Janeiro, Brazil, Santos (tours to Sao Paulo), Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Puerto Madryn, Argentina, Ushuaia, Argentina, Cape Horn, Chile (Sail by), Punta Arenas, Chile, Amalia Glacier, Chile (Scenic Cruising), PIO X Glacier, Chile (Scenic Cruising), Puerto Montt, Chile, San Antonio CL (tours to Santiago), Chile, Coquimbo, Chile, Arica, Chile, Callao (tours to Lima), Peru, Manta, Ecuador, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Oranjestad, Aruba, Fort Lauderdale, FL, Port Canaveral, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2027 Sails: Jan 10, More...
127 Night - Navigate the World
Starting in Miami, Cruising the Caribbean Sea, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Roatan, Cruising the Caribbean Sea, George Town, Ocho Rios, Jamaica, Cruising the Caribbean Sea, Puerto Limon, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti), Moorea, Huahine, Raiatea, Bora Bora, Cruising the South Pacific, Pago Pago, Cross the International Date Line, Apia, Cruising the South Pacific, Suva, Lautoka, Cruising the South Pacific, Mystery Island, Lifou Island, Noumea, Cruising the Coral Sea, Cruising the Tasman Sea, Sydney AU, Cruising the Tasman Sea, Cruising the Coral Sea, Townsville, Cairns, Cooktown, Cruising the Coral Sea, Cruising the Arafura Sea, Darwin, Cruising the Timor Sea, Komodo, Bali (Benoa), Surabaya, Semarang (Java), Cruising the Java Sea, Singapore, Kuala Lumpur (Port Klang), Penang, Phuket, Cruising the Andaman Sea, Cruising the Bay of Bengal, Colombo, Cruising the Laccadive Sea, Male, Cruising the Laccadive Sea, Cochin (Kochi), Mangalore, Goa (Mormugao), Mumbai (Bombay), Cruising the Arabian Sea, Muscat, Dubai, Doha, Abu Dhabi, Cruising the Gulf of Oman, Cruising the Arabian Sea, Salalah, Cruising the Arabian Sea, Cruising the Gulf of Aden, Cruising the Red Sea, Jeddah, Cruising the Red Sea, Luxor (Safaga), Aqaba, Suez Canal (Transit), Jerusalem (Haifa), Limassol, Rhodes, Kusadasi, Athens (Piraeus), Cruising the Mediterranean Sea, Sorrento / Capri, Rome (Civitavecchia)
2027 Sails: Jan 11, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Curacao, Fort Lauderdale, Florida
2026 Sails: Dec 3, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Dec 12, 2027: Feb 14, Apr 19, More...
90 Night - South America DiscoveryStarting in Hamburg, Germany, Rotterdam, Netherlands, Zeebrugge (tours to Bruges), Belgium, Southampton, England, UK, Hamilton, Bermuda, Port Canaveral, FL, Fort Lauderdale, FL, Grand Turk, Turks and Caicos Islands, Bridgetown, Barbados, Fortaleza, Brazil, Salvador, Brazil, Buzios, Brazil, Rio De Janeiro, Brazil, Santos (tours to Sao Paulo), Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Puerto Madryn, Argentina, Ushuaia, Argentina, Cape Horn, Chile (Sail by), Punta Arenas, Chile, Amalia Glacier, Chile (Scenic Cruising), PIO X Glacier, Chile (Scenic Cruising), Puerto Montt, Chile, San Antonio CL (tours to Santiago), Chile, Coquimbo, Chile, Arica, Chile, Callao (tours to Lima), Peru, Manta, Ecuador, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Oranjestad, Aruba, Fort Lauderdale, FL, Port Canaveral, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK, Zeebrugge (tours to Bruges), Belgium, Hamburg, Germany
2027 Sails: Jan 5, More...
Deal link -> Special
20 Night - Panama Canal & CaribbeanStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 5, More...
Deal link -> Special
10 Night - Panama PotpourriStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2027 Sails: Jan 5, More...
23 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Hilo, Hawaii, Kahului, Hawaii, Honolulu, Hawaii
2027 Sails: Jan 6, More...
15 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2027 Sails: Jan 6, More...
Deal link -> Special
129 Night - Wc Grand Circle Pacific - Ft. Lauderdale to Los AngelesStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Hilo, Hawaii, Kahului, Hawaii, Honolulu, Hawaii, Kauai (Nawiliwili), Hawaii, Pago Pago, American Samoa, Cross International Date Line, Suva, Fiji, Dravuni Island, Fiji, Port Vila, Vanuatu, Luganville, Vanuatu, Rabaul, Papua New Guinea, Alotau (Milne Bay), Papua New Guinea, Cairns, Australia, Airlie Beach, Australia, Brisbane, Australia, Sydney AU, Auckland, New Zealand, Tauranga, New Zealand, Christchurch (Lyttelton), New Zealand, Dunedin (Port Chalmers), New Zealand, Fiordland National Park (Scenic Cruising), Hobart, Australia, Adelaide, Australia, Perth (Fremantle), Australia, Kimberley Coast (Scenic Cruising), Australia, Darwin, Australia, Bali (Benoa), Indonesia, Lombok, Indonesia, Singapore, Phuket, Thailand, Langkawi, Malaysia, Penang, Malaysia, Kuala Lumpur (Port Kelang), Malaysia, Ho Chi Minh City (Phu My), Vietnam, Cam Ranh (Nha Trang), Vietnam, Halong Bay / Hanoi (Cai Lan), Vietnam, Hong Kong, Taipei (Keelung), Miyakojima, Japan, Kagoshima, Japan, Kochi, Japan, Osaka (for Kyoto), Japan, Tokyo, Japan, Miyako, Japan, Kushiro, Japan, Cross International Date Line, Anchorage (Whittier), Alaska, College Fjord (Scenic Cruising), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Sitka, Alaska, Juneau, Alaska, Ketchikan, Alaska, Vancouver, Canada, Los Angeles, California
2027 Sails: Jan 6, More...
82 Night - South America DiscoveryStarting in Southampton, England, UK, Hamilton, Bermuda, Port Canaveral, FL, Fort Lauderdale, FL, Grand Turk, Turks and Caicos Islands, Bridgetown, Barbados, Fortaleza, Brazil, Salvador, Brazil, Buzios, Brazil, Rio De Janeiro, Brazil, Santos (tours to Sao Paulo), Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Puerto Madryn, Argentina, Ushuaia, Argentina, Cape Horn, Chile (Sail by), Punta Arenas, Chile, Amalia Glacier, Chile (Scenic Cruising), PIO X Glacier, Chile (Scenic Cruising), Puerto Montt, Chile, San Antonio CL (tours to Santiago), Chile, Coquimbo, Chile, Arica, Chile, Callao (tours to Lima), Peru, Manta, Ecuador, Fuerte Amador (tours to Panama City), Panama, Transit the Panama Canal, Panama (Full Transit), Oranjestad, Aruba, Fort Lauderdale, FL, Port Canaveral, FL, Ponta Delgada, Azores, Portugal, Southampton, England, UK
2027 Sails: Jan 10, More...
127 Night - Navigate the WorldStarting in Miami, Cruising the Caribbean Sea, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Roatan, Cruising the Caribbean Sea, George Town, Ocho Rios, Jamaica, Cruising the Caribbean Sea, Puerto Limon, Cruising the Caribbean Sea, Cartagena CO, Panama Canal Transit, Panama City, Cruising the Pacific Ocean, Puntarenas, Cruising the Pacific Ocean, Acajutla, Puerto Quetzal, Cruising the Pacific Ocean, Puerto Vallarta, Cabo San Lucas, Cruising the Pacific Ocean, Los Angeles, Cruising the Pacific Ocean, Honolulu, Kahului, Hilo, Cruising the Pacific Ocean, Bora Bora, Moorea, Papeete (Tahiti), Moorea, Huahine, Raiatea, Bora Bora, Cruising the South Pacific, Pago Pago, Cross the International Date Line, Apia, Cruising the South Pacific, Suva, Lautoka, Cruising the South Pacific, Mystery Island, Lifou Island, Noumea, Cruising the Coral Sea, Cruising the Tasman Sea, Sydney AU, Cruising the Tasman Sea, Cruising the Coral Sea, Townsville, Cairns, Cooktown, Cruising the Coral Sea, Cruising the Arafura Sea, Darwin, Cruising the Timor Sea, Komodo, Bali (Benoa), Surabaya, Semarang (Java), Cruising the Java Sea, Singapore, Kuala Lumpur (Port Klang), Penang, Phuket, Cruising the Andaman Sea, Cruising the Bay of Bengal, Colombo, Cruising the Laccadive Sea, Male, Cruising the Laccadive Sea, Cochin (Kochi), Mangalore, Goa (Mormugao), Mumbai (Bombay), Cruising the Arabian Sea, Muscat, Dubai, Doha, Abu Dhabi, Cruising the Gulf of Oman, Cruising the Arabian Sea, Salalah, Cruising the Arabian Sea, Cruising the Gulf of Aden, Cruising the Red Sea, Jeddah, Cruising the Red Sea, Luxor (Safaga), Aqaba, Suez Canal (Transit), Jerusalem (Haifa), Limassol, Rhodes, Kusadasi, Athens (Piraeus), Cruising the Mediterranean Sea, Sorrento / Capri, Rome (Civitavecchia)
2027 Sails: Jan 11, More...
