Panama City Cruises
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
20 Night - Caribbean Kaleidoscope
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 17, More...10 Night - Passage to Panama
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2026 Sails: Jan 17, More...
15 Night - New York to Los Angeles
Starting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA
2026 Sails: Jan 19, More...18 Night - New York to San Francisco
Starting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA
2026 Sails: Jan 19, More...44 Night - New York to Sydney
Starting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia
2026 Sails: Jan 19, More...109 Night - Full World Voyage
Starting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia, Brisbane, Australia, Yorkeys Knob (tours to Cairns), Australia, Darwin, NT, Australia, Bitung, Indonesia, Hong Kong, China, Chan May (tours to Hue or Da Nang), Vietnam, Singapore, Port Kelang (tours to Kuala Lumpur), Malaysia, Port Louis, Mauritius, Durban, South Africa, Cape Town, South Africa, Walvis Bay, Namibia, Dakar, Senegal, Tenerife, Spain, Cadiz (tours to Seville), Spain, Southampton, England, UK, Le Havre, France, New York, NY
2026 Sails: Jan 19, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Jan 24, More...10 Night - Canal & Caribbean Discovery
Starting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 27, More...16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Feb 9, Sep 20, Dec 28, 2027: Mar 2, Apr 3, More...
15 Night - Panama Canal-Panama City
Starting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2026 Sails: Feb 12, More...
Cruises that visit Central America: Panama: Panama City
Cruises that depart from Panama City
Click on a cruise ship itinerary that visits Panama City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Panama City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
20 Night - Caribbean KaleidoscopeStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 17, More...
10 Night - Passage to PanamaStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2026 Sails: Jan 17, More...
15 Night - New York to Los AngelesStarting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA
2026 Sails: Jan 19, More...
18 Night - New York to San FranciscoStarting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA
2026 Sails: Jan 19, More...
44 Night - New York to SydneyStarting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia
2026 Sails: Jan 19, More...
109 Night - Full World VoyageStarting in New York, NY, Cartagena CO, Transit the Panama Canal, Panama (Full Transit), Fuerte Amador (tours to Panama City), Panama, Manzanillo, Mexico, Los Angeles, CA, San Francisco, CA, Honolulu, HI, Kona, HI, Papeete, French Polynesia, Moorea, French Polynesia, Cross International Date Line (Cruise-by), Bay of Islands, New Zealand, Auckland, New Zealand, Tauranga, New Zealand, Sydney AU, Australia, Brisbane, Australia, Yorkeys Knob (tours to Cairns), Australia, Darwin, NT, Australia, Bitung, Indonesia, Hong Kong, China, Chan May (tours to Hue or Da Nang), Vietnam, Singapore, Port Kelang (tours to Kuala Lumpur), Malaysia, Port Louis, Mauritius, Durban, South Africa, Cape Town, South Africa, Walvis Bay, Namibia, Dakar, Senegal, Tenerife, Spain, Cadiz (tours to Seville), Spain, Southampton, England, UK, Le Havre, France, New York, NY
2026 Sails: Jan 19, More...
16 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Jan 24, More...
10 Night - Canal & Caribbean DiscoveryStarting in Panama City, Panama Canal Daylight Transit, Cartagena CO, Kralendijk, Willemstad AN, Oranjestad, Port Antonio, Miami
2026 Sails: Jan 27, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Feb 9, Sep 20, Dec 28, 2027: Mar 2, Apr 3, More...
15 Night - Panama Canal-Panama CityStarting in San Diego, Ca, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puntarenas / Puerto Caldera, Costa Rica, Panama City, Panama, Transit Panama Canal / At Sea, Cartagena CO, Miami, Fl
2026 Sails: Feb 12, More...
