Colon Cruises
Cruises that visit Central America: Panama: Colon
Cruises that depart from Colon
30 Night - Miami to Seattle
Starting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 14, More...
10 Night - Vivid Western Caribbean
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City
2026 Sails: Apr 14, More...
18 Night - Msc Grand Voyages
Starting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
15 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Los Angeles, Ca
2026 Sails: Apr 25, More...18 Night - Panama Canal - Miami
Starting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Los Angeles, Ca, Seattle, Wa
2026 Sails: Apr 25, More...
7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, More...7 Night - Southern Caribbean Cruise
Starting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...19 Night - Msc Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...
12 Night - Panama Canal Discovery : Costa Rica & Greater Antilles
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Oct 18, Dec 27, 2027: Jan 17, Feb 7, Feb 28, Mar 21, More...21 Night - Panama Canal & Southern Caribbean : Abc Islands
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Cabo Rojo, Dominican Republic, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 18, More...
Cruises that visit Central America: Panama: Colon
Cruises that depart from Colon
Click on a cruise ship itinerary that visits Colon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Colon), please visit: Cruise Search or try our Virtual Cruise Advisor™.
30 Night - Miami to SeattleStarting in Miami, FL, Cartagena CO, Colon, Panama, Transit the Panama Canal, Panama (Full Transit), Puntarenas, Costa Rica, Santa Cruz (for Huatulco), Mexico, Puerto Vallarta, Mexico, San Diego, CA, Seattle, WA, Ketchikan, AK, Sitka, AK, Glacier Bay, AK, (Scenic Cruising), Juneau, AK, Skagway, AK, Tracy Arm Fjord, AK, (Scenic Cruising), Victoria CA, Canada, Seattle, WA
2026 Sails: Apr 14, More...
10 Night - Vivid Western CaribbeanStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Belize City, Roatan, Puerto Limon, Colon, Panama Canal Daylight Transit, Panama City
2026 Sails: Apr 14, More...
18 Night - Msc Grand VoyagesStarting in Miami, Florida, Cartagena CO, Colon, Panama, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Cabo San Lucas, Mexico, San Diego, Los Angeles, Seattle, Washington
2026 Sails: Apr 23, More...
15 Night - Panama Canal - MiamiStarting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Los Angeles, Ca
2026 Sails: Apr 25, More...
18 Night - Panama Canal - MiamiStarting in Miami, Fl, Cartagena CO, Colon, Panama, Transit Panama Canal / At Sea, Puerto Caldera / Puntarenas, Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, Los Angeles, Ca, Seattle, Wa
2026 Sails: Apr 25, More...
7 Night - Southern Caribbean CruiseStarting in Cartagena CO, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: May 10, May 17, May 24, May 31, Jun 7, Jun 14, Jun 21, Jun 28, Jul 5, Jul 12, Jul 19, Jul 26, Aug 2, Aug 9, Aug 16, Aug 23, Aug 30, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, More...
7 Night - Southern Caribbean CruiseStarting in Cartagena CO, Kralendijk, Bonaire, Oranjestad, Aruba, Willemstad AN, Curacao, Colon, Panama, Cartagena CO
2026 Sails: Sep 6, More...
19 Night - Msc Grand VoyagesStarting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...
12 Night - Panama Canal Discovery : Costa Rica & Greater AntillesStarting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida
2026 Sails: Oct 18, Dec 27, 2027: Jan 17, Feb 7, Feb 28, Mar 21, More...
21 Night - Panama Canal & Southern Caribbean : Abc IslandsStarting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Cabo Rojo, Dominican Republic, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 18, More...
