Central America Cruises
Cruises that visit Central America
Cruises by region
See all Central America River Cruises
Related areas: Belize : Costa Rica : El Salvador : Guatemala : Honduras : Nicaragua : Panama
19 Night - MSC Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...24 Night - MSC Grand Voyages
Starting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami, Florida
2026 Sails: Sep 28, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 29, More...
17 Night - Panama Canal Eastbound Cruise
Starting in Los Angeles, California, Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama Canal (Cruising), Cartagena CO, Ocho Rios, Jamaica, George Town, Grand Cayman, Tampa, Florida
2026 Sails: Oct 1, More...
16 Night - Panama Canal
Starting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...
21 Night - Panama Canal
Starting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...
14 Night - Eastern / Western Caribbean Adventurer
Starting in Fort Lauderdale, Florida, Roatan (Mahogany Bay, Honduras), Belize City, Belize, Cozumel, Mexico, Fort Lauderdale, Florida, Princess Cays, Bahamas, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Nassau, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...20 Night - Panama Canal
Starting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
16 Night - Panama Canal - Ocean to Ocean
Starting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
6 Night - Western Caribbean Cruise
Starting in Galveston, Texas, Cozumel, Mexico, Roatan, Honduras, Puerto Costa Maya, Mexico, Galveston, Texas
2026 Sails: Oct 4, More...
Cruises that visit Central America
Cruises by region
See all Central America River Cruises
Click on a cruise ship itinerary in Central America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Central America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Belize : Costa Rica : El Salvador : Guatemala : Honduras : Nicaragua : Panama
19 Night - MSC Grand VoyagesStarting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida
2026 Sails: Sep 28, More...
24 Night - MSC Grand VoyagesStarting in Seattle, Washington, Los Angeles, San Diego, Cabo San Lucas, Mexico, Puntarenas (San Jose), Costa Rica, Cruising Panama Canal, Colon, Panama, Cartagena CO, Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Miami, Florida
2026 Sails: Sep 28, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit Historic Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Sep 29, More...
17 Night - Panama Canal Eastbound CruiseStarting in Los Angeles, California, Puerto Vallarta, Mexico, Puerto Quetzal, Guatemala, Puntarenas, Costa Rica, Panama Canal (Cruising), Cartagena CO, Ocho Rios, Jamaica, George Town, Grand Cayman, Tampa, Florida
2026 Sails: Oct 1, More...
16 Night - Panama CanalStarting in San Diego, California, Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Acajutla, El Salvador, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Cartagena CO, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 2, More...
21 Night - Panama CanalStarting in Seattle, Washington, Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...
14 Night - Eastern / Western Caribbean AdventurerStarting in Fort Lauderdale, Florida, Roatan (Mahogany Bay, Honduras), Belize City, Belize, Cozumel, Mexico, Fort Lauderdale, Florida, Princess Cays, Bahamas, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Nassau, Bahamas, Fort Lauderdale, Florida
2026 Sails: Oct 3, More...
20 Night - Panama CanalStarting in Vancouver, BC, CA, Santa Barbara, California, San Diego, California, Cabo San Lucas, Mexico, Acapulco, Guerrero, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puerto Quetzal, Guatemala, Puntarenas (Puerto Caldera), Costa Rica, Enter Panama Canal Balboa, Cruising Panama Canal, Exit Panama Canal Cristobal, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
16 Night - Panama Canal - Ocean to OceanStarting in Los Angeles, California, Cabo San Lucas, Mexico, Mazatlan, Mexico, Fuerte Amador, Panama (for Panama City), Panama Canal Full Transit New Locks, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 4, More...
6 Night - Western Caribbean CruiseStarting in Galveston, Texas, Cozumel, Mexico, Roatan, Honduras, Puerto Costa Maya, Mexico, Galveston, Texas
2026 Sails: Oct 4, More...
