Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Virgin Voyages, Valiant Lady

10 Night - Moroccan Marvels & Mediterranean Wonders
Starting in Barcelona, Spain, Tangier, Morocco, Lisbon, Portugal, La Coruna, Spain, Bilbao, Bordeaux (Le Verdon), France, Portsmouth UK, United Kingdom
2026 Sails: Jul 26, More...

Cunard Line, Queen Victoria

14 Night - Italy and Adriatic
Starting in Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Naples (tours to Capri or Pompeii), Italy, Civitavecchia (tours to Rome), Italy
2026 Sails: Jul 27, More...

Cunard Line, Queen Victoria

7 Night - Italy and Adriatic
Starting in Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy
2026 Sails: Jul 27, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Italian Riviera & France
Starting in Barcelona, Spain, Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Portofino, Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Jul 28, More...

Holland America, Oosterdam

20 Night - Solar Eclipse Collectors' Voyage : Spain & Morrocco
Starting in Barcelona, Spain, Ibiza, Spain, Alicante, Spain, Malaga, Spain, Tangier, Morocco, Lisbon, Portugal, Alicante, Spain, Barcelona, Spain, Ajaccio, Corsica, France, Civitavecchia (Rome), Italy, Bari (Puglia), Italy, Kotor, Montenegro, Scenic cruising Bay of Kotor, Piraeus (Athens), Greece
2026 Sails: Aug 2, More...

Norwegian Cruise Line, Norwegian Dawn

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona (Tarragona), Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Aug 2, More...

Royal Caribbean, Legend of the Seas

7 Night - Western Mediterranean Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Aug 2, Aug 9, Aug 16, Aug 23, More...

Virgin Voyages, Scarlet Lady

8 Night - French Riviera, Italy & Spain
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Marseille (Provence), France, Cannes, France, Ajaccio, Corsica, France, La Spezia, Italy, Barcelona, Spain
2026 Sails: Aug 2, More...

Explora Journeys, EXPLORA I

Deal link -> Special

7 Night - A Journey Through Mediterranean Beauty, Artistic Spirit & Eternal Charms
Starting in Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome)
2026 Sails: Aug 3, Aug 31, Sep 28, More...

Explora Journeys, EXPLORA I

14 Night - An Extended Journey from Cultural Gems to Riviera Magic & Balmy Beaches
Starting in Barcelona, Ibiza, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome), Porto Santo Stefano (Argentario), Monte Carlo, Saint-Tropez, Tarragona, Palma De Mallorca, Barcelona
2026 Sails: Aug 3, More...

<= Back

More =>