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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Departing from
Spain
Cruise Specials

AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Wine Cruise) with Bilbao, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cadillac, Bordeaux, Paris
2026 Sails: Apr 12, May 31, Jun 28, Jul 19, Aug 2, Aug 9, 2027: Mar 14, Mar 21, Mar 28, Apr 4, Jul 4, Jul 11, Jul 18, Aug 1, Aug 8, Aug 15, Sep 26, Nov 21, Nov 28, Dec 5, Dec 12, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa10 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Savona, Marseille, Malaga, Gibraltar, Cadice, Casablanca, Tangier, Barcelona
2026 Sails: Apr 12, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Apr 12, Apr 19, Sep 6, Sep 13, Sep 20, Sep 27, Oct 4, Oct 11, Oct 18, Oct 25, Nov 1, Nov 8, Nov 15, More...
MSC Cruises, MSC Musica
MSC Musica10 Night - Canary Islands and Madeira
Starting in Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Casablanca (Marrakesh), Morocco, Barcelona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France
2026 Sails: Apr 12, More...
MSC Cruises, MSC Musica
MSC Musica8 Night - Canary Islands and Madeira
Starting in Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Casablanca (Marrakesh), Morocco, Barcelona, Spain, Civitavecchia (Rome), Italy
2026 Sails: Apr 12, More...
MSC Cruises, MSC Musica
MSC Musica9 Night - Canary Islands and Madeira
Starting in Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Casablanca (Marrakesh), Morocco, Barcelona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Apr 12, More...
AmaWaterways Tours, AmaKristina Tours
AmaKristina Tours13 Night - Colors of Provence with Barcelona Pre-Cruise and Paris Post-Cruise
Starting in Barcelona, Arles, Avignon, Vivigani, Tournon, Vienne, Paris
2026 Sails: Apr 13, May 11, May 25, Jun 22, Jul 6, Jul 20, Aug 3, Aug 17, Aug 31, Sep 14, Oct 12, 2027: Mar 15, Apr 12, Apr 26, May 10, May 24, Jun 7, Aug 2, Aug 16, Aug 30, Sep 13, Sep 27, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda3 Night - Western Mediterranean from Barcelona to Palermo
Starting in Barcelona, La Goulette, Palermo
2026 Sails: Apr 13, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, La Goulette, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Apr 13, Apr 20, Apr 27, May 4, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - Canary Islands and Madeira
Starting in Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Casablanca (Marrakesh), Morocco, Barcelona, Spain, Civitavecchia (Rome), Italy
2026 Sails: Apr 13, More...

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Spain Cruise Departures