Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Fred Olsen Cruise Lines, Balmoral

53 Night - Western Mediterranean from Alicante to Santa Cruz de Tenerife
Starting in Alicante, Mahon, Savona, La Spezia, Bastia, Propriano, Pass Amalfi Coast, Salerno, Pass Maratea Coast, Cruising by Stromboli, Cruising the Strait of Messina, Valletta, Brindisi, Split, Koper, Cruising Bay of Kotor, Kotor, Cruising Bay of Kotor, Kotor, Dubrovnik, Croatia, Kerkira, Heraklion, Ermoupolis, Pass Mount Athos, Cruising Sithonia Coastline, Thessaloniki, Mytilene, Kos, Rhodes, Limassol, Alexandria EG, Marmaris, Istanbul, Piraeus (for Athens), Valletta, Trapani, Cartagena ES, Gibraltar, Agadir, Santa Cruz de Tenerife
2026 Sails: Oct 8, More...

Fred Olsen Cruise Lines, Balmoral

42 Night - Western Mediterranean from Alicante to Athens (Piraeus)
Starting in Alicante, Mahon, Savona, La Spezia, Bastia, Propriano, Pass Amalfi Coast, Salerno, Pass Maratea Coast, Cruising by Stromboli, Cruising the Strait of Messina, Valletta, Brindisi, Split, Koper, Cruising Bay of Kotor, Kotor, Cruising Bay of Kotor, Kotor, Dubrovnik, Croatia, Kerkira, Heraklion, Ermoupolis, Pass Mount Athos, Cruising Sithonia Coastline, Thessaloniki, Mytilene, Kos, Rhodes, Limassol, Alexandria EG, Marmaris, Istanbul, Piraeus (for Athens)
2026 Sails: Oct 8, More...

Carnival Cruise Lines, Carnival Freedom

8 Night - Mediterranean
Starting in Barcelona, Spain, Marseilles (Provence), France, Livorno (Florence / Pisa), Italy, Civitavecchia (Rome), Italy, Naples (Amalfi / Pompeii), Italy, Valletta, Malta, Barcelona, Spain
2026 Sails: Oct 9, More...

Costa Cruise Lines, Costa Diadema

10 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Spain, Tangier, Morocco, Casablanca, Morocco, Cadiz, Spain, Gibraltar (UK), Malaga, Spain, Marseille, France, Savona, Italy, Barcelona, Spain
2026 Sails: Oct 9, More...

Celebrity Cruises, Celebrity Equinox

10 Night - Italy, France & Malta Cruise
Starting in Barcelona, Spain, Valletta, Malta, Sicily (Messina), Italy, Naples, Italy, Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Barcelona, Spain
2026 Sails: Oct 10, More...

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: Oct 10, Oct 17, Oct 27, Nov 3, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Ibiza, Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Oct 10, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Oct 11, Oct 18, Oct 25, Nov 1, More...

Norwegian Cruise Line, Norwegian Dawn

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: Oct 11, More...

Virgin Voyages, Scarlet Lady

14 Night - Spain to Morocco & Miami Transatlantic
Starting in Barcelona, Spain, Casablanca, Morocco, Gran Canaria, Las Palmas, Spain, Santa Cruz de Tenerife, Miami
2026 Sails: Oct 11, More...

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