Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Explora Journeys, EXPLORA I

22 Night - An Extended Journey of Creative Spirit, Enchanting Sights & Ancient Whispers
Starting in Barcelona, Port of Naples, La Valletta, Siracusa (Sicily), Corfu, Kotor, Brindisi, Split, Fusina (Venice), Zadar, Dubrovnik, Croatia, Bari, Mykonos, Istanbul, Cesme, Syros (Syra), Piraeus (Athens)
2026 Sails: Apr 2, More...

Explora Journeys, EXPLORA I

4 Night - A Journey of Cultural Marvels & Natural Beauty
Starting in Barcelona, Port of Naples, La Valletta
2026 Sails: Apr 2, More...

PONANT, Le Bougainville

7 Night - The Canaries, Lands of Contrast
Starting in Las Palmas de Gran Canaria, Canary Islands, Arrecife de Lanzarote, Canary Islands, Puerto del Rosario, Canary Islands, Santa Cruz de Tenerife, Santa Cruz de La Palma, La Estaca, Canary Islands, San Sebastian de la Gomera, Canary Islands, Las Palmas de Gran Canaria, Canary Islands
2026 Sails: Apr 2, More...

Regent Seven Seas, Seven Seas Voyager

8 Night - Viva Espana
Starting in Malaga, Cadiz, Tangier, Gibraltar, Almeria, Cartagena ES, Ibiza, Palma De Mallorca, Barcelona
2026 Sails: Apr 2, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Apr 4, Jun 6, Jun 27, Aug 29, 2027: Apr 11, More...

Princess Cruises, Sun Princess

21 Night - The Best of the Mediterranean
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Apr 4, Jun 6, Jun 27, Aug 29, 2027: Apr 11, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Apr 4, Jun 6, Jun 27, Aug 29, 2027: Apr 11, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia, Genoa, Marseille, Barcelona
2026 Sails: Apr 5, More...

Costa Cruise Lines, Costa Fortuna

12 Night - Cruise from Santa Cruz de Tenerife to Savona
Starting in Santa Cruz de Tenerife, La Gomera, Canary Islands, Fuerteventura, Canary Islands, Arrecife, Canary Islands, Atlantis Crest West, Las Palmas, Canary Islands, Santa Cruz de Tenerife, Funchal (Madeira), Casablanca, Morocco, Barcelona, Spain, Marseille, France, Savona, Italy
2026 Sails: Apr 6, More...

Costa Cruise Lines, Costa Fortuna

5 Night - Cruise Roundtrip from Santa Cruz de Tenerife
Starting in Santa Cruz de Tenerife, La Gomera, Canary Islands, Fuerteventura, Canary Islands, Arrecife, Canary Islands, Atlantis Crest West, Las Palmas, Canary Islands, Santa Cruz de Tenerife
2026 Sails: Apr 6, More...

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