Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Alicante, Spain, Port Mahon, Minorca, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain
2026 Sails: May 20, Aug 8, More...

Viking Ocean, Viking Jupiter

14 Night - Trade Routes of the Middle Ages
Starting in Barcelona, Barcelona (Tarragona), Murcia (Cartagena ES, Spain), Granada (Malaga), Sail the Atlantic Ocean, Porto (Leixoes), Sail the Atlantic Ocean, Falmouth, Portsmouth UK, Paris (Le Havre), Bruges (Zeebrugge), Amsterdam, Sail the North Sea, Bergen
2026 Sails: May 20, More...

Azamara Cruises, Azamara Journey

5 Night - Spain & France Cruise : Toulon, Ibiza & Palma
Starting in Barcelona, Provence (Toulon), Mahon, Menorca, Ibiza, Spain, Palma, Majorca, Ibiza, Spain, Barcelona
2026 Sails: May 21, More...

Regent Seven Seas, Seven Seas Voyager

12 Night - Eastern Mediterranean Gems
Starting in Barcelona, Cruising the Mediterranean Sea, Messina (Sicily), Cruising the Ionian Sea, Dubrovnik, Croatia, Kotor, Corfu, Gythion, Rhodes, Cruising Aegean Sea, Santorini, Mykonos, Athens (Piraeus)
2026 Sails: May 21, More...

Royal Caribbean, Harmony of the Seas

3 Night - Spain & France Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Provence (Marseille), France, Barcelona, Spain
2026 Sails: May 21, More...

Celebrity Cruises, Celebrity Xcel

10 Night - Italy & French Riviera
Starting in Barcelona, Spain, Naples, Italy, Sicily (Messina), Italy, Rome (Civitavecchia), Italy, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Nice (Villefranche), France, Barcelona, Spain
2026 Sails: May 22, Oct 2, More...

Lindblad Expeditions, National Geographic Orion

12 Night - Mediterranean Wonders : Sicily, Greece, Sardinia and Beyond
Starting in Barcelona, Spain / Embark Ship, Ciutadella de Menorca, At Sea / Bonifacio, Corsica, France, Bonifacio, Golfo Aranci, Sardinia, Italy, At Sea / Aeolian Islands, Taormina, Sicily, Siracusa / At Sea, Corfu, Greece, Cephalonia, Delphi / Corinth Canal, Athens / Disembark Ship
2026 Sails: May 22, 2027: Apr 7, Aug 9, More...

Celebrity Cruises, Celebrity Equinox

10 Night - Greek Isles & Turkey
Starting in Barcelona, Spain, Valletta, Malta, Athens (Piraeus), Greece, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Olympia (Katakolon), Greece, Rome (Civitavecchia), Italy
2026 Sails: May 23, More...

Disney Cruise Line, Disney Dream

7 Night - Mediterranean Cruise from Barcelona
Starting in Barcelona, Cagliari, Naples, Civitavecchia, Livorno, Barcelona
2026 Sails: May 23, More...

Norwegian Cruise Line, Norwegian Dawn

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Palma Majorca, Spain, Valencia, Spain, Motril, Spain, Gibraltar, Cadiz / Seville, Spain, Portimao, Portugal, Lisbon, Portugal
2026 Sails: May 24, Jun 21, Jul 5, Jul 19, Aug 30, Sep 13, More...

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