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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Oceania Cruises, Oceania Marina
Oceania Marina10 Night - Radiant Rivieras
Starting in Barcelona, Alicante, Ibiza, Palma De Mallorca, Sete, Toulon, Ajaccio (Corsica), Monte Carlo, Portofino, Florence / Pisa / Tuscany (Livorno), Rome (Civitavecchia)
2026 Sails: Nov 5, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa10 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Gibraltar, Tangier, Casablanca, Cadiz, Malaga, Marseille, Savona, Barcelona
2026 Sails: Nov 6, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia8 Night - Mediterranean
Starting in Valencia, Spain, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain
2026 Sails: Nov 6, Nov 20, More...
MSC Cruises, MSC World Europa
MSC World Europa6 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, Barcelona, Spain
2026 Sails: Nov 6, More...
AmaWaterways, AmaVida
AmaVida7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Nov 7, 2027: Mar 27, Apr 10, Nov 6, More...
Azamara Cruises, Azamara Onward
Azamara Onward10 Night - Spain Intensive Cruise : Valencia, Malaga & Seville
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Gibraltar, Seville, Lisbon
2026 Sails: Nov 7, More...
PONANT, Le Dumont-d'Urville
Le Dumont-d'Urville8 Night - Atlantic Odyssey from the Iberian Peninsula to the Canary Islands
Starting in Malaga, Tangier, Casablanca, Funchal, Madeira, Arrecife de Lanzarote, Canary Islands, Santa Cruz de La Palma, Las Palmas de Gran Canaria, Canary Islands
2026 Sails: Nov 7, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Palma De Mallorca, Naples, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Nov 8, More...
MSC Cruises, MSC Sinfonia
MSC Sinfonia7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain, Barcelona, Spain
2026 Sails: Nov 8, Nov 22, More...
Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Barcelona
Starting in Barcelona, Marseille, Palma De Mallorca, Gibraltar, Malaga (Costa del Sol), Cartagena ES, Spain, Valencia, Barcelona
2026 Sails: Nov 8, More...

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Spain Cruise Departures