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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: May 18, May 25, Jun 29, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, More...
Cunard Line, Queen Victoria
Queen Victoria7 Night - Italy, France and Spain
Starting in Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: May 18, Jun 15, More...
Cunard Line, Queen Victoria
Queen Victoria14 Night - Italy, France and Spain
Starting in Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain, Palma De Mallorca, Spain, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: May 18, More...
MSC Cruises, MSC Magnifica
MSC Magnifica9 Night - Northern Europe
Starting in Barcelona, Spain, La Coruna (Santiago De Compostela), Spain, Bilbao, La Rochelle, France, Brest, France, Warnemunde (Berlin), Germany
2026 Sails: May 18, More...
Windstar, Star Legend
Star Legend8 Night - Moroccan Markets & Iberian Icons
Starting in Barcelona, Valencia, Cartagena ES, Malaga, Tangier, Cruising Guadalquivir River, Seville, Lisbon
2026 Sails: May 18, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: May 19, May 26, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, More...
Silversea, Silver Ray
Silver Ray10 Night - Barcelona to Civitavecchia
Starting in Barcelona, Palma De Mallorca, Marseille, Monte Carlo, Portofino, Livorno (Tuscany), Salerno, Civitavecchia (Rome)
2026 Sails: May 19, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia, Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia
2026 Sails: May 20, Jul 8, Jul 15, Jul 22, Jul 29, Aug 5, Aug 12, More...
Explora Journeys, EXPLORA I
EXPLORA I7 Night - A Journey of Bewitching Scenery & Cultural Treasures
Starting in Barcelona, Marseille, Porto Cervo (Sardinia), Portofino, Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona
2026 Sails: May 20, More...
Explora Journeys, EXPLORA I
EXPLORA I14 Night - An Extended Journey of Cultural Treasures and Glittering Shorelines
Starting in Barcelona, Marseille, Porto Cervo (Sardinia), Portofino, Livorno (Florence), Villefranche-Sur-Mer (Nice), Barcelona, Mahon (Menorca), Cannes, Saint-Tropez, Alghero (Sardinia), Civitavecchia (Rome), Monte Carlo
2026 Sails: May 20, More...

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Spain Cruise Departures