Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Fascinosa

3 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: Nov 3, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, La Goulette (Tunis), Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Nov 3, More...

AmaWaterways Tours, AmaVida Tours

13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Pinhao, Entre-os-Rios, Porto, Lisbon
2026 Sails: Nov 4, More...

Holland America, Oosterdam

14 Night - Cultural Crossing with Andalusia
Starting in Barcelona, Spain, Cartagena ES, Malaga, Spain, Gibraltar, Kings Wharf, Bermuda, Fort Lauderdale, Florida
2026 Sails: Nov 4, More...

Star Clippers, Star Flyer

9 Night - Morocco & Canary Islands
Starting in Malaga, Spain, Gibraltar, British Overseas Territory, Tangier, Morocco, Cadiz, Spain, Safi, Morocco, Arrecife / Lanzarote / Canary Islands, Spain, Santa Cruz de Tenerife, Las Palmas, Gran Canaria / Canary Islands, Spain
2026 Sails: Nov 4, More...

Star Clippers, Star Flyer

24 Night - Westbound Atlantic Ocean Crossing
Starting in Malaga, Spain, Gibraltar, British Overseas Territory, Tangier, Morocco, Cadiz, Spain, Safi, Morocco, Arrecife / Lanzarote / Canary Islands, Spain, Santa Cruz de Tenerife, Las Palmas, Gran Canaria / Canary Islands, Spain, Arrecife / Lanzarote / Canary Islands, Spain, Philipsburg, St Maarten
2026 Sails: Nov 4, More...

Windstar, Star Legend

8 Night - Spanish Mystery Cruise
Starting in Barcelona, Mystery Port, Malaga
2026 Sails: Nov 4, More...

Windstar, Star Legend

23 Night - Star Collector : Spanish Mystery & Atlantic Crossing
Starting in Barcelona, Mystery Port, Malaga, Tangier, Casablanca, Funchal, Madeira, Bridgetown, Barbados
2026 Sails: Nov 4, More...

MSC Cruises, MSC Magnifica

8 Night - Mediterranean
Starting in Tarragona, Spain, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Nov 5, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Tarragona, Spain
2026 Sails: Nov 5, More...

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