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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

AmaWaterways, AmaVida
AmaVida7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Jul 4, Jul 18, Aug 1, Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, 2027: Apr 10, Apr 24, May 8, May 22, Jun 5, Jun 19, Jul 3, Jul 17, Jul 31, Aug 14, Aug 28, Sep 11, Sep 25, Oct 9, Oct 23, More...
Celebrity Cruises, Celebrity Xcel
Celebrity Xcel7 Night - Italy & France Cruise
Starting in Barcelona, Spain, Provence (Marseille), France, Portofino, Italy, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Jul 4, Aug 1, More...
Virgin Voyages, Valiant Lady
Valiant Lady7 Night - French Riviera, Italy & Ibiza Overnight
Starting in Barcelona, Spain, Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Cannes, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jul 4, More...
MSC Cruises, MSC Opera
MSC Opera10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Jul 5, Jul 15, Jul 25, Aug 4, Aug 14, Aug 24, Sep 3, Sep 13, Sep 23, More...
Regent Seven Seas, Seven Seas Navigator
Seven Seas Navigator14 Night - Landmarks of Lisbon & Lorient
Starting in Barcelona, Cruising the Mediterranean Sea, Malaga, Lisbon, Oporto, Cruising the Bay of Biscay, Bordeaux, Lorient, St Peter Port, Guernsey, Paris (Le Havre), Dunkirk, London (Dover UK)
2026 Sails: Jul 5, More...
Costa Cruise Lines, Costa Smeralda
Costa Smeralda7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Jul 6, Sep 28, More...
Disney Cruise Line, Disney Dream
Disney Dream7 Night - Mediterranean Cruise from Barcelona
Starting in Barcelona, Livorno, Civitavecchia, Naples, Cagliari, Barcelona
2026 Sails: Jul 6, More...
Explora Journeys, EXPLORA I
EXPLORA I7 Night - A Journey Across Mediterranean Masterpieces
Starting in Barcelona, Palma De Mallorca, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome)
2026 Sails: Jul 6, More...
Explora Journeys, EXPLORA I
EXPLORA I14 Night - An Extended Voyage of Antique Treasures, Volcanic Views & Tranquil Shores
Starting in Barcelona, Palma De Mallorca, Tunis / La Goulette, La Valletta, Giardini Naxos, Sorrento, Civitavecchia (Rome), Porto Santo Stefano (Argentario), Monte Carlo, Saint-Tropez, Valencia, Mahon (Menorca), Barcelona
2026 Sails: Jul 6, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, More...

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Spain Cruise Departures