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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Costa Cruise Lines, Costa Smeralda
Costa Smeralda5 Night - Europe from Barcelona to Savona
Starting in Barcelona, La Goulette, Palermo, Civitavecchia, Savona
2026 Sails: Mar 23, More...
AmaWaterways Tours, AmaVida Tours
AmaVida Tours13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto, Lisbon
2026 Sails: Mar 25, Apr 8, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Nov 18, 2027: Mar 24, Apr 7, May 5, May 19, Jun 2, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, Oct 6, Oct 20, Nov 17, More...
Explora Journeys, EXPLORA I
EXPLORA I19 Night - An Extended Journey of Sunlit Sophistication & Spectacular Shorelines
Starting in Barcelona, Marseille, Ajaccio (Corsica), Livorno (Florence), Civitavecchia (Rome), Valencia, Palma De Mallorca, Barcelona, Port of Naples, La Valletta, Siracusa (Sicily), Corfu, Kotor, Brindisi, Split, Fusina (Venice)
2026 Sails: Mar 25, More...
Explora Journeys, EXPLORA I
EXPLORA I8 Night - A Journey Through Mediterranean Gems & Historic Grandeur
Starting in Barcelona, Marseille, Ajaccio (Corsica), Livorno (Florence), Civitavecchia (Rome), Valencia, Palma De Mallorca, Barcelona
2026 Sails: Mar 25, More...
Explora Journeys, EXPLORA I
EXPLORA I4 Night - A Journey Through Europe's Timeless Charm & Cultural Richness
Starting in Barcelona, Marseille, Ajaccio (Corsica), Livorno (Florence), Civitavecchia (Rome)
2026 Sails: Mar 25, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa4 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: Mar 26, More...
AmaWaterways, AmaVida
AmaVida7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Mar 28, Oct 24, 2027: Mar 27, Nov 6, More...
Viking Ocean, Viking Vesta
Viking Vesta7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Mar 28, Nov 11, 2027: Feb 25, More...
Viking Ocean, Viking Vesta
Viking Vesta14 Night - Mediterranean Antiquities
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Mar 28, More...
MSC Cruises, MSC Armonia
MSC Armonia7 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Split, Croatia, Venice / Marghera, Italy
2026 Sails: Mar 29, More...

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Spain Cruise Departures