Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Jun 28, Jul 5, Jul 12, Jul 19, More...

Norwegian Cruise Line, Norwegian Epic

7 Night - Europe - Western Mediterranean - Barcelona
Starting in Barcelona, Spain, Provence, Marseille, France, Nice / Monaco (Villefranche), France, Livorno / Florence / Pisa, Italy, Messina, Italy, Amalfi Coast (Salerno), Italy, Civitavecchia Rome, Italy
2026 Sails: Jun 28, Jul 12, Jul 26, Aug 9, Oct 4, Oct 18, More...

Royal Caribbean, Harmony of the Seas

7 Night - Western Mediterranean Cruise
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Jun 28, Jul 5, Jul 19, More...

Virgin Voyages, Valiant Lady

6 Night - French Riviera, Italy, & Ibiza Overnight
Starting in Barcelona, Spain, Nice (Villafranche), France, Rome (Civitavecchia), Italy, Ajaccio, Corsica, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jun 28, More...

Costa Cruise Lines, Costa Smeralda

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Ibiza, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Jun 29, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain
2026 Sails: Jun 29, Jul 9, Jul 19, Jul 29, Aug 8, Aug 18, Aug 28, Sep 7, Sep 17, Sep 27, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Ibiza
Starting in Ibiza, Valencia, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Jun 30, More...

Windstar, Wind Surf

7 Night - Yachtsman's Harbors of the Rivieras
Starting in Barcelona, Palamos, Sanary-sur-mer, Monte Carlo, Cannes, Portofino, Portoferraio, Rome
2026 Sails: Jun 30, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Valencia
Starting in Valencia, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca, Valencia
2026 Sails: Jul 1, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain
2026 Sails: Jul 2, Jul 16, Jul 23, Jul 30, Aug 13, Aug 20, Aug 27, Sep 3, More...

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