Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Explora Journeys, EXPLORA I

11 Night - A Journey of Creative Spirit & Enchanting Canals
Starting in Barcelona, Port of Naples, La Valletta, Siracusa (Sicily), Corfu, Kotor, Brindisi, Split, Fusina (Venice)
2026 Sails: Apr 2, More...

Explora Journeys, EXPLORA I

22 Night - An Extended Journey of Creative Spirit, Enchanting Sights & Ancient Whispers
Starting in Barcelona, Port of Naples, La Valletta, Siracusa (Sicily), Corfu, Kotor, Brindisi, Split, Fusina (Venice), Zadar, Dubrovnik, Croatia, Bari, Mykonos, Istanbul, Cesme, Syros (Syra), Piraeus (Athens)
2026 Sails: Apr 2, More...

Explora Journeys, EXPLORA I

4 Night - A Journey of Cultural Marvels & Natural Beauty
Starting in Barcelona, Port of Naples, La Valletta
2026 Sails: Apr 2, More...

Regent Seven Seas, Seven Seas Voyager

8 Night - Viva Espana
Starting in Malaga, Cadiz, Tangier, Gibraltar, Almeria, Cartagena ES, Ibiza, Palma De Mallorca, Barcelona
2026 Sails: Apr 2, More...

MSC Cruises, MSC Musica

7 Night - Canary Islands and Madeira
Starting in Las Palmas de Gran Canaria (Canary Islands), Spain, Funchal (Madeira Islands), Portugal, Santa Cruz de Tenerife, Arrecife De Lanzarote (Canary Islands), Spain, Puerto Del Rosario / Fuerteventura, Spain, Santa Cruz de La Palma, Las Palmas de Gran Canaria (Canary Islands), Spain
2026 Sails: Apr 3, More...

MSC Cruises, MSC Splendida

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Palermo (Monreale), Italy, La Goulette, Tunisia, Barcelona, Spain
2026 Sails: Apr 4, Apr 11, Apr 18, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Apr 4, Jun 6, Jun 27, Aug 29, 2027: Apr 11, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Apr 4, Jun 6, Jun 27, Aug 29, 2027: Apr 11, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Apr 5, More...

Costa Cruise Lines, Costa Fortuna

12 Night - Western Mediterranean from Santa Cruz de Tenerife to Savona
Starting in Santa Cruz de Tenerife, La Gomera, Canary Islands, Fuerteventura, Canary Islands, Arrecife, Canary Islands, Atlantis Crest West, Las Palmas, Canary Islands, Santa Cruz de Tenerife, Funchal (Madeira), Moroccan Sea Darkest Spot, Casablanca, Morocco, Barcelona, Spain, Marseille, France, Savona, Italy
2026 Sails: Apr 6, More...

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