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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Costa Cruise Lines, Costa Toscana
Costa Toscana5 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Civitavecchia, Genoa, Marseille, Barcelona
2026 Sails: Mar 3, More...
Silversea, Silver Muse
Silver Muse10 Night - Barcelona to Civitavecchia
Starting in Barcelona, Valencia, Sete, Marseille, Menton, Genoa, Livorno (Tuscany), Porto Santo Stefano, Civitavecchia (Rome)
2026 Sails: Mar 5, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Wine Cruise) with Bilbao, San Sebastian Pre-Cruise and Paris Post Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cadillac, Bordeaux, Paris
2026 Sails: Mar 8, Apr 12, May 31, Jun 28, Jul 19, Aug 2, Aug 9, 2027: Mar 14, Mar 21, Mar 28, Apr 4, Jul 4, Jul 11, Jul 18, Aug 1, Aug 8, Aug 15, Sep 26, Nov 21, Nov 28, Dec 5, Dec 12, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux (Wine Cruise) with Bilbao, San Sebastian Pre-Cruise and Loire Valley, Paris Charles De Gaulle Post-Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Cadillac, Bordeaux, Loire Valley / Amboise, Amboise, Paris
2026 Sails: Mar 8, Apr 12, May 31, Jun 28, Jul 19, Aug 2, Aug 9, 2027: Mar 14, Mar 21, Mar 28, Apr 4, Jul 4, Jul 11, Jul 18, Aug 1, Aug 8, Aug 15, Sep 26, Nov 21, Nov 28, Dec 5, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Napoli, Civitavecchia, Genoa, Marseille, Barcelona
2026 Sails: Mar 8, Mar 15, Mar 22, Mar 29, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Cruise Roundtrip from Santa Cruz de Tenerife
Starting in Santa Cruz de Tenerife, Arrecife, Canary Islands, Atlantis Crest East, Agadir, Morocco, Las Palmas, Canary Islands, Funchal (Madeira), Canary Sea Darkest Spot, Santa Cruz de Tenerife
2026 Sails: Mar 9, More...
Viking Ocean, Viking Mars
Viking Mars7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Mar 9, More...
Viking Ocean, Viking Mars
Viking Mars14 Night - Mediterranean & Italian Sojourn
Starting in Barcelona, Sete, Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina)
2026 Sails: Mar 9, More...
Norwegian Cruise Line, Norwegian Luna
Norwegian Luna11 Night - Repo - Transatlantic
Starting in Barcelona, Spain, Gibraltar, Miami, Fl
2026 Sails: Mar 12, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux with Bilbao, San Sebastian Pre-Cruise and Loire Valley, Paris Charles De Gaulle Post-Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Pauillac, Cadillac, Bordeaux, Loire Valley / Amboise, Amboise, Paris
2026 Sails: Mar 15, Mar 29, Apr 5, Apr 19, Apr 26, May 3, May 10, May 24, Jun 7, Jun 14, Jun 21, Jul 5, Jul 12, Jul 26, Aug 16, Aug 23, Aug 30, Sep 6, Sep 20, Oct 4, Oct 11, 2027: Mar 7, Apr 11, Apr 18, More...

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Spain Cruise Departures