Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Valencia
Starting in Valencia, La Spezia (Florence), Civitavecchia (Rome), Savona, Marseille, Palma De Mallorca, Valencia
2026 Sails: May 6, More...

PONANT, Le Champlain

11 Night - Heavenly Islands & Iberian Shores
Starting in Barcelona, Mahon, Balearic Islands, Ibiza, Balearic Islands, Valencia, Cartagena, Motril, Malaga, Cadiz, Portimao, Lisbon, Figueira da Foz, Leixoes / Porto
2026 Sails: May 6, More...

MSC Cruises, MSC Musica

7 Night - Mediterranean
Starting in Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain
2026 Sails: May 7, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 16, Jul 23, Jul 30, Aug 13, Aug 20, Aug 27, Sep 3, More...

MSC Cruises, MSC Seaview

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: May 7, May 14, May 21, May 28, Jun 4, Jun 11, Jun 18, Jun 25, Jul 2, Jul 9, Jul 16, Jul 23, Jul 30, Aug 6, Aug 13, Aug 20, Aug 27, Sep 3, Sep 10, Sep 17, Sep 24, Oct 1, Oct 8, Oct 15, More...

Royal Caribbean, Explorer of the Seas

9 Night - Italy, France & Croatia Cruise
Starting in Barcelona, Spain, Nice (Villefranche), France, Florence / Pisa (La Spezia), Italy, Rome (Civitavecchia), Italy, Dubrovnik, Croatia, Kotor, Montenegro, Zadar, Croatia, Ravenna, Italy
2026 Sails: May 7, More...

Costa Cruise Lines, Costa Fascinosa

4 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: May 8, Oct 23, More...

Explora Journeys, EXPLORA I

5 Night - A Journey of Historic Beauty & Coastal Discovery
Starting in Cartagena ES, Saint-Tropez, Monte Carlo, Livorno (Florence), Civitavecchia (Rome)
2026 Sails: May 8, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote D Azur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain
2026 Sails: May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2026 Sails: May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Oct 2, Oct 9, Oct 16, More...

MSC Cruises, MSC World Europa

Deal link -> Special

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: May 8, May 15, May 22, May 29, Jun 5, Jun 12, Jun 19, Jun 26, Jul 3, Jul 10, Jul 17, Jul 24, Jul 31, Aug 7, Aug 14, Aug 21, Aug 28, Sep 4, Sep 11, Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, More...

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