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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron : Vigo

Departing from
Spain
Cruise Specials

Explora Journeys, EXPLORA I
EXPLORA I8 Night - A Journey Through Mediterranean Gems & Historic Grandeur
Starting in Barcelona, Marseille, Ajaccio (Corsica), Livorno (Florence), Civitavecchia (Rome), Valencia, Palma De Mallorca, Barcelona
2026 Sails: Mar 25, More...
Explora Journeys, EXPLORA I
EXPLORA I4 Night - A Journey Through Europe's Timeless Charm & Cultural Richness
Starting in Barcelona, Marseille, Ajaccio (Corsica), Livorno (Florence), Civitavecchia (Rome)
2026 Sails: Mar 25, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa4 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: Mar 26, More...
PONANT, Le Bougainville
Le Bougainville7 Night - The Canaries, Lands of Contrast
Starting in Las Palmas de Gran Canaria, Canary Islands, Arrecife de Lanzarote, Canary Islands, Puerto del Rosario, Canary Islands, Santa Cruz de Tenerife, Santa Cruz de La Palma, La Estaca, Canary Islands, Las Palmas de Gran Canaria, Canary Islands
2026 Sails: Mar 26, More...
Costa Cruise Lines, Costa Fortuna
Costa Fortuna7 Night - Western Mediterranean Roundtrip from Las Palmas
Starting in Las Palmas, Canary Islands, Funchal (Madeira), Canary Sea Darkest Spot, Santa Cruz de Tenerife, La Gomera, Canary Islands, Fuerteventura, Canary Islands, Arrecife, Canary Islands, Atlantis Crest West, Las Palmas, Canary Islands
2026 Sails: Mar 27, Apr 3, More...
MSC Cruises, MSC World Europa
MSC World Europa7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Mar 27, Apr 10, More...
AmaWaterways, AmaVida
AmaVida7 Night - Flavors of Portugal & Spain
Starting in Vega de Terron, Barca dAlva, Pinhao, Regua, Entre-os-Rios, Porto
2026 Sails: Mar 28, 2027: Mar 27, Nov 6, More...
MSC Cruises, MSC Orchestra
MSC Orchestra7 Night - Mediterranean
Starting in Valencia, Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Valencia, Spain
2026 Sails: Mar 28, Apr 11, More...
Viking Ocean, Viking Vesta
Viking Vesta7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Mar 28, Nov 11, More...
AmaWaterways Tours, AmaDolce Tours
AmaDolce Tours14 Night - Taste of Bordeaux with Bilbao, San Sebastian Pre-Cruise and Loire Valley, Paris Charles De Gaulle Post-Cruise
Starting in Bilbao, San Sebastian, Bordeaux, Libourne, Blaye, Bourg, Pauillac, Cadillac, Bordeaux, Loire Valley / Amboise, Aboisso, Paris
2026 Sails: Mar 29, Apr 5, Apr 19, Apr 26, May 3, May 10, May 24, Jun 7, Jun 14, Jun 21, Jul 5, Jul 12, Jul 26, Aug 16, Aug 23, Aug 30, Sep 6, Sep 20, Oct 4, Oct 11, 2027: Mar 7, Apr 11, Apr 18, Apr 25, More...

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Spain Cruise Departures