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Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Cartagena ES : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Departing from
Spain
Cruise Specials

Cunard Line, Queen Victoria
Queen Victoria7 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey
2026 Sails: May 4, More...
Cunard Line, Queen Victoria
Queen Victoria21 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: May 4, More...
Cunard Line, Queen Victoria
Queen Victoria14 Night - Mediterranean and Greek Islands
Starting in Barcelona, Spain, Heraklion, Crete, Greece, Kusadasi (tours to Ephesus), Turkey, Dardanelles Strait, Turkey (Transit), Istanbul, Turkey, Dardanelles Strait, Turkey (Transit), Piraeus (tours to Athens), Greece, Mykonos, Greece, Katakolon (tours to Olympia), Greece, Messina Strait, Italy (Transit), Barcelona, Spain
2026 Sails: May 4, More...
Costa Cruise Lines, Costa Fascinosa
Costa Fascinosa3 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Marseille, Savona, Barcelona
2026 Sails: May 5, May 12, More...
Costa Cruise Lines, Costa Pacifica
Costa Pacifica7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Valencia, La Spezia (Florence), Civitavecchia (Rome), Savona, Marseille, Palma De Mallorca
2026 Sails: May 5, More...
MSC Cruises, MSC Meraviglia
MSC Meraviglia7 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: May 5, May 12, May 19, May 26, Jun 2, Jun 9, Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, More...
PONANT, Le Boreal
Le Boreal9 Night - Ancient Shores of the Mediterranean
Starting in Malaga, Cartagena, Oran, Algiers, Tunis, Palermo, Sicily, Trapani, Sicily, Palermo, Sicily, Syracuse IT, Sicily, Valletta
2026 Sails: May 5, More...
AmaWaterways Tours, AmaVida Tours
AmaVida Tours13 Night - Flavors of Portugal & Spain with Madrid Pre-Cruise and Lisbon Post-Cruise
Starting in Madrid, Salamanca, Vega de Terron, Bermuda, Pinhao, El Dorado, Porto, Lisbon
2026 Sails: May 6, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 23, Oct 7, Nov 18, Dec 2, 2027: Mar 24, Apr 7, Apr 21, May 5, May 19, Jun 2, Jun 16, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, More...
Costa Cruise Lines, Costa Favolosa
Costa Favolosa11 Night - Transatlantic from Barcelona
Starting in Barcelona, Malaga, Cadice, Lisbon, Leixoes, La Coruna, Le Havre, Dover UK, Hamburg
2026 Sails: May 6, More...

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Spain Cruise Departures