Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain, Cannes (Cote Dazur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain
2026 Sails: Sep 18, Sep 25, Oct 2, Oct 16, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain
2026 Sails: Sep 18, Oct 2, Oct 9, Oct 16, More...

MSC Cruises, MSC World Europa

7 Night - Mediterranean
Starting in Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Naples (Pompeii), Italy, Messina (Taormina), Italy, La Valletta, Malta, Barcelona, Spain
2026 Sails: Sep 18, Sep 25, Oct 2, Oct 9, Oct 16, Oct 23, Oct 30, More...

Regent Seven Seas, Seven Seas Mariner

11 Night - Enchanted Evenings
Starting in Barcelona, Palma De Mallorca, Cruising the Mediterranean Sea, Monte Carlo, Cruising the Ligurian Sea, Tuscany (Livorno), Rome (Civitavecchia)
2026 Sails: Sep 18, More...

Emerald Cruises, Emerald Sakara

9 Night - Spanish Shores & Beyond
Starting in Palma De Mallorca, Spain, Ibiza, Spain, Mahon, Menorca, Spain, Porto Cervo, Italy, Calvi, France, Saint-Tropez, France, Monte Carlo, Monaco, Port Vendres, France, Barcelona, Spain
2026 Sails: Sep 19, More...

MSC Cruises, MSC Grandiosa

7 Night - Mediterranean
Starting in Barcelona, Spain, Cannes (Cote Dazur), France, Genoa (Portofino), Italy, La Spezia (Cinque Terre), Italy, Civitavecchia (Rome), Italy, Palma De Mallorca (Balearic Islands), Spain, Barcelona, Spain
2026 Sails: Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, More...

MSC Cruises, MSC Orchestra

7 Night - Mediterranean
Starting in Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain
2026 Sails: Sep 19, Sep 26, Oct 3, Oct 10, Oct 17, More...

Princess Cruises, Sun Princess

7 Night - Western Mediterranean with Italy
Starting in Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy
2026 Sails: Sep 19, More...

Princess Cruises, Sun Princess

14 Night - Mediterranean with Greece, Italy & Turkey
Starting in Barcelona, Spain, Ibiza, Spain, Corsica (Ajaccio), France, Marseille (Provence), France, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Sep 19, More...

Costa Cruise Lines, Costa Toscana

7 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Cagliari, Naples, Civitavecchia (Rome), Genoa (Portofino), Marseille, Barcelona
2026 Sails: Sep 20, More...

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