Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Royal Caribbean, Harmony of the Seas

13 Night - Spain Transatlantic
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Cartagena ES, Malaga, Spain, Seville (Cadiz), Spain, Orlando (Port Canaveral), Fl
2026 Sails: Jul 26, More...

Virgin Voyages, Valiant Lady

10 Night - Moroccan Marvels & Mediterranean Wonders
Starting in Barcelona, Spain, Tangier, Morocco, Lisbon, Portugal, La Coruna, Spain, Bilbao, Bordeaux (Le Verdon), France, Portsmouth UK, United Kingdom
2026 Sails: Jul 26, More...

Cunard Line, Queen Victoria

14 Night - Italy and Adriatic
Starting in Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Naples (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Jul 27, More...

Cunard Line, Queen Victoria

7 Night - Italy and Adriatic
Starting in Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy
2026 Sails: Jul 27, More...

Cunard Line, Queen Victoria

21 Night - Adriatic and Western Mediterranean
Starting in Barcelona, Spain, Salerno (tours to Capri or Pompeii), Italy, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Corfu, Greece, Kotor, Montenegro, Trieste, Italy, Zadar, Croatia, Dubrovnik, Croatia, Valletta, Malta, Naples (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Tarragona, Spain, Palma De Mallorca, Spain, Villefranche, France, Marseille, France, Barcelona, Spain
2026 Sails: Jul 27, More...

Celebrity Cruises, Celebrity Equinox

9 Night - Italian Riviera & France
Starting in Barcelona, Spain, Rome (Civitavecchia), Italy, Florence / Pisa (La Spezia), Italy, Portofino, Italy, Nice (Villefranche), France, Provence (Marseille), France, Barcelona, Spain
2026 Sails: Jul 28, More...

Viking Ocean, Viking Sea

7 Night - Iconic Western Mediterranean
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Jul 28, 2028: May 16, More...

Viking Ocean, Viking Sea

28 Night - Mediterranean's Iconic Shores
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Chioggia), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Jul 28, More...

Viking Ocean, Viking Sea

21 Night - Mediterranean & Adriatic Sojourn
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Chioggia), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Jul 28, More...

Viking Ocean, Viking Sea

14 Night - Mediterranean & Italian Sojourn
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Chioggia)
2026 Sails: Jul 28, More...

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