Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Princess Cruises, Sun Princess

21 Night - The Best of the Mediterranean
Starting in Barcelona, Spain, Mallorca (Palma), Spain, Marseille (Provence), France, Corsica (Ajaccio), France, Santa Margherita, Italy, Genoa (for Cinque Terre), Italy, La Spezia (for Florence / Pisa), Italy, Civitavecchia (for Rome), Italy, Naples, Italy (for Capri and Pompeii), Crete (Chania), Greece, Kusadasi, Turkey (for Ephesus), Mykonos, Greece, Athens (Piraeus), Greece, Santorini, Greece, Montenegro, Corfu, Greece, Sicily (Messina), Italy, Barcelona, Spain
2026 Sails: Jul 18, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Alicante, Spain, Mahon Minorque, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain
2026 Sails: Jul 19, More...

Virgin Voyages, Valiant Lady

7 Night - Tuscany, Corsica & Ibiza
Starting in Barcelona, Spain, Provence (Toulon), France, Florence / Pisa (Livorno), Italy, Ajaccio, Corsica, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jul 19, More...

Disney Cruise Line, Disney Dream

7 Night - Western Europe Cruise from Barcelona Ending in Southampton
Starting in Barcelona, Cartagena ES, Malaga, Vigo, La Coruna, Southampton
2026 Sails: Jul 20, More...

Explora Journeys, EXPLORA I

14 Night - An Extended Journey of Historic Discovery & Bewitching Scenery
Starting in Barcelona, Cannes, Portofino, Livorno (Florence), Porto Cervo (Sardinia), Ajaccio (Corsica), Civitavecchia (Rome), Port of Naples, Capri, Calvi (Corsica), Villefranche-Sur-Mer (Nice), Marseille, Mahon (Menorca), Barcelona
2026 Sails: Jul 20, Aug 17, More...

Explora Journeys, EXPLORA I

7 Night - A Journey Through the Picturesque Mediterranean & Historic Beauty of the Sparkling Riviera
Starting in Barcelona, Cannes, Portofino, Livorno (Florence), Porto Cervo (Sardinia), Ajaccio (Corsica), Civitavecchia (Rome)
2026 Sails: Jul 20, Aug 17, More...

Viking Ocean, Viking Vesta

28 Night - Mediterranean's Iconic Shores
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Jul 21, More...

Viking Ocean, Viking Vesta

21 Night - Mediterranean & Adriatic Sojourn
Starting in Barcelona, Sete, Marseille, Monte Carlo, Florence / Pisa (Livorno), Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice (Fusina), Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus)
2026 Sails: Jul 21, More...

Virgin Voyages, Scarlet Lady

9 Night - Rome, Florence, Corsica & Ibiza
Starting in Barcelona, Spain, Palma De Mallorca, Spain, Cannes, France, Rome (Civitavecchia), Italy, Florence / Pisa (Livorno), Italy, Ajaccio, Corsica, France, Ibiza, Spain, Barcelona, Spain
2026 Sails: Jul 24, More...

Celebrity Cruises, Celebrity Xcel

7 Night - Italy & French Riviera
Starting in Barcelona, Spain, Nice (Villefranche), France, Florence / Pisa (La Spezia), Italy, Santa Margherita, Italy, Rome (Civitavecchia), Italy, Naples, Italy, Barcelona, Spain
2026 Sails: Jul 25, More...

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